Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Huamin Wang"'
Autor:
Christophe, Glorieux, Xiaojun, Xia, Xin, You, Zining, Wang, Yi, Han, Jing, Yang, Gauthier, Noppe, Christophe de, Meester, Jianhua, Ling, Annie, Robert, Hui, Zhang, Sheng-Ping, Li, Huamin, Wang, Paul J, Chiao, Li, Zhang, Xiaobing, Li, Peng, Huang
Publikováno v:
Journal of Advanced Research, p. [1-16] (2021)
INTRODUCTION: Immunochemotherapy using PD-1/PD-L1 antibodies in combination with chemotherapeutic agents has become a mainstream treatment for cancer patients, but it remains unclear which drug combination would produce best therapeutic outcome. The
Autor:
Huamin Wang, Elizabeth Forbes, Jason B. Fleming, Zhixiang Zhang, Weijun Tian, Longhao Sun, Boris Pasche, Ya'an Kang, Qianqian Song, Xuebin Zhang, Wei Zhang, Liang Liu
Publikováno v:
Cancer Lett
Tumor-associated macrophages (TAMs) represent the M2-like phenotype with potent immunosuppressive activity, and play a pro-tumor role in pancreatic ductal adenocarcinoma (PDAC) biology. In this study, we investigated the role of the insulin-like grow
Autor:
Y. Alan Wang, Xin Zhou, Jun Li, Denise J. Spring, Wenting Liao, Qiang Zhang, Shan Jiang, Chang-Jiun Wu, Pingping Hou, Ronald A. DePinho, Jeffery Ackroyd, Jianhua Zhang, Jun Zhao, Huamin Wang, Xingdi Ma, Carolyn Guan
Publikováno v:
Genes & Development. 33:1361-1366
The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases. Cancer genomic analysis identified frequent amplification of USP21 (22%) in human pancreatic ductal adenocarcinoma (PDAC). USP21 overexpression correlates with h
Autor:
Stefan T. Arold, Huamin Wang, Ganiraju C. Manyam, Chad D. Huff, Richard G. Fowler, Scott Kopetz, Paul Scheet, Yao Yu, Yulun Liu, Joe Ensor, David G. Menter, Michael T. Tetzlaff, F. Anthony San Lucas, Liana Adam, Wenhui Wu, Michael J. Overman
Publikováno v:
Clinical Cancer Research. 25:641-651
Purpose: Little is known about the genetic alterations characteristic of small bowel adenocarcinoma (SBA). Our purpose was to identify targetable alterations and develop experimental models of this disease. Experimental Design: Whole-exome sequencing
Autor:
Michael P. Kim, Eric P. Tamm, Kim A. Reiss, Peter C. Park, Brian P. Hobbs, Shun Yu, Vittorio Cristini, Anil Chauhan, Naveen Garg, Jeffrey E. Lee, Prajnan Das, Deyali Chatterjee, Huaming Yan, Anirban Maitra, Eugene J. Koay, Cullen M. Taniguchi, Huamin Wang, Milind Javle, Yeonju Lee, F. Anthony San Lucas, Ahmed M. Amer, John Lowengrub, Dali Li, Matthew H.G. Katz, Christopher H. Crane, Mauro Ferrari, Gauri R. Varadhachary, Priya Bhosale, Mohamed Zaid, Rong Ye, Newsha Nikzad, Rachna T. Shroff, Ya'an Kang, Robert A. Wolff, Jason B. Fleming, Dalia Elganainy, Mayrim V. Rios Perez, Muayad F. Almahariq
Publikováno v:
Clinical Cancer Research. 24:5883-5894
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics of PDAC tumors on diagnostic computed tomography (CT)
Autor:
Kathleen M. McAndrews, Yang Chen, J. Kebbeh Darpolor, Xiaofeng Zheng, Sujuan Yang, Julienne L. Carstens, Bingrui Li, Huamin Wang, Toru Miyake, Pedro Correa de Sampaio, Michelle L. Kirtley, Mariangela Natale, Chia-Chin Wu, Hikaru Sugimoto, Valerie S. LeBleu, Raghu Kalluri
Publikováno v:
Cancer Discov
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a significant accumulation of fibroblasts as part of the host response to cancer. Using single-cell RNA sequencing, multiplex immunostaining, and several genetic mouse mod
Autor:
Yihui Chen, Michela Capello, Mayrim V. Rios Perez, Jody V. Vykoukal, David Roife, Ya'an Kang, Laura R. Prakash, Hiroyuki Katayama, Ehsan Irajizad, Alia Fleury, Sammy Ferri-Borgogno, Dodge L. Baluya, Jennifer B. Dennison, Kim-Anh Do, Oliver Fiehn, Anirban Maitra, Huamin Wang, Paul J. Chiao, Matthew H.G. Katz, Jason B. Fleming, Samir M. Hanash, Johannes F. Fahrmann
Publikováno v:
Molecular Metabolism, Vol 56, Iss, Pp 101426-(2022)
Objective: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation
Autor:
Yang, Chen, Jiha, Kim, Sujuan, Yang, Huamin, Wang, Chang-Jiun, Wu, Hikaru, Sugimoto, Valerie S, LeBleu, Raghu, Kalluri
Publikováno v:
Cancer cell. 39(4)
Stromal desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC) involves significant accumulation of type I collagen (Col1). However, the precise molecular and mechanistic contribution of Col1 in PDAC progression remains unknown. Activated p
Autor:
Huamin Wang, Cassian Yee, Samantha N. Delaney, Yulun Chiu, David Fry, Ying Ma, Anirban Maitra, Charles V. Kingsley, Jun Li, Spencer C. Wei, Jianhua Zhang
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Advanced pancreatic ductal adenocarcinoma (PDAC) is resistant to therapy, including immune checkpoint inhibitors. We evaluated the effects of a neutralizing antibody against programmed cell death 1 (PDCD1, also called PD1) and an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c27d0737bb4780a5e7a99b421d430c
https://europepmc.org/articles/PMC7387152/
https://europepmc.org/articles/PMC7387152/
Autor:
Fenglin Zang, Reza Abbasgholizadeh, Hua Wang, Anirban Maitra, Ji-Hyun Shin, Huamin Wang, Craig D. Logsdon, Jiayi Chen, Hironari Akasaka, Xianzhou Song, Andrew J. Bean
Publikováno v:
J Biol Chem
The oncogenic receptor tyrosine kinase AXL is overexpressed in cancer and plays an important role in carcinomas of multiple organs. However, the mechanisms of AXL overexpression in cancer remain unclear. In this study, using HEK293T, Panc-1, and Panc