Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Wenyu Lin"'
Autor:
Wenting Li, Wenyu Lin, Zeng Tu, Baihai Jiao, Esperance A. Schaefer, Xiao Liu, Limin Chen, Xiaoqiong Duan, Dachuan Cai, Shadi Salloum, Shilin Li, Chunhui Yang, Dahlene N. Fusco, Jacinta A. Holmes, Raymond T. Chung, Yujia Li
Publikováno v:
Journal of Virology
Hepatitis C virus (HCV) infection has been shown to regulate microRNA 130a (miR-130a) in patient biopsy specimens and in cultured cells. We sought to identify miR-130a target genes and to explore the mechanisms by which miR-130a regulates HCV and hep
Autor:
Run-Xuan Shao, Andrew W. Tai, Raymond T. Chung, Lee F. Peng, Ethan M. Weinberg, Sun Suk Kim, Carolina B. De Sa Borges, Wenyu Lin, Kyung Ah Kim, Mark A. Brockman
Publikováno v:
Gastroenterology. 134:803-811
Background & Aims: Human immunodeficiency virus (HIV) coinfection increases hepatitis C virus (HCV)-related progression of hepatic fibrosis, increases HCV persistence, and decreases response rates to interferon-based anti-HCV therapy. It has remained
Autor:
Stuart L. Schreiber, Lee F. Peng, Sun Suk Kim, Raymond T. Chung, Wenyu Lin, Naoya Sakamoto, Won-Hyeok Choe
Publikováno v:
Gastroenterology. 132:311-320
Background & Aims: Only half of patients with chronic hepatitis C virus (HCV) infection experience sustained virologic response to pegylated-interferon and ribavirin, which cause numerous side effects. Thus, the identification of more effective and b
Autor:
Yoichi Hiasa, Raymond T. Chung, Wenyu Lin, Emmett V. Schmidt, Won Hyeok Choe, Yoshitaka Kamegaya, Jason T. Blackard
Publikováno v:
Gastroenterology. 128:1034-1041
Background & Aims: The molecular mechanisms by which hepatitis C virus (HCV) antagonizes the antiviral actions of interferon (IFN) have not been fully characterized. Specifically, how HCV proteins impact on IFN signaling components has yet to be eluc
Autor:
Wenyu Lin, Victor W. Hsu, Run-Xuan Shao, Leiliang Zhang, Zhi Hong, Kaku Goto, Raymond T. Chung
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e32135 (2012)
PLoS ONE, Vol 7, Iss 2, p e32135 (2012)
Cellular levels of phosphatidylinositol 4-phosphate (PI4P) have been shown to be upregulated during RNA replication of several viruses, including the HCV replicon model. However, whether PI4P is required in an infectious HCV model remains unknown. Mo
Autor:
Yaakov Nahmias, Patrick Balaguer, Danny Kitsberg, Wenyu Lin, Raymond T. Chung, Martin L. Yarmush, Pazit Y. Cohen, Stephen J. Polyak, Jonathan Goldwasser
Publikováno v:
Journal of hepatology. 55(5)
Background & Aims Hepatitis C virus (HCV) infection affects 3% of the world population and is the leading cause of chronic liver disease worldwide. Current standard of care is effective in only 50% of the patients, poorly tolerated, and associated wi
Autor:
Yoshitaka Kamegaya, Michael J. Holtzman, Jason T. Blackard, Wenyu Lin, Raymond T. Chung, Kyung Ah Kim, Elaine Yeung, Sun Suk Kim
Publikováno v:
Journal of virology. 80(18)
Emerging data have indicated that hepatitis C virus (HCV) subverts the host antiviral response to ensure its persistence. We previously demonstrated that HCV protein expression suppresses type I interferon (IFN) signaling by leading to the reduction
Autor:
Wenyu Lin, Eun Kyung Cho, Young Seok Kim, Jae Young Jang, Eui Ju Park, Hong Soo Kim, Woong Cheul Lee, Sang Gyune Kim, Soung Won Jeong, Sae Hwan Lee, Boo Sung Kim, Seong-Jun Kim, Raymond T. Chung
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98171 (2014)
PLoS ONE
PLoS ONE
Hepatitis C virus (HCV) infection causes chronic liver diseases leading to hepatocellular carcinoma (HCC) and liver failure. We have previously shown that HCV sensitizes hepatocytes to mitochondrial apoptosis via the TRAIL death receptors DR4 and DR5