Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Stephen S Whitehead"'
Autor:
Julie Callison, Dana P. Scott, Andrea Marzi, Nicolette Arndt, Stephen S. Whitehead, Kristin L. McNally, David Safronetz, Spencer Chadinha, Heinz Feldmann, Cynthia Martellaro, Jackson Emanuel, Rebecca Rosenke, Sonja M. Best
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
The common small animal disease models for Zika virus (ZIKV) are mice lacking the interferon responses, but infection of interferon receptor α/β knock out (IFNAR−/−) mice is not uniformly lethal particularly in older animals. Here we sought to
Autor:
Konstantin A. Tsetsarkin, Konstantin Chumakov, Majid Laassri, Stephen S. Whitehead, Alexander G. Pletnev, Heather Kenney, Rubing Chen, Guangping Liu, Hasmik Manukyan
Publikováno v:
mBio, Vol 7, Iss 4, p e01114-16 (2016)
mBio
mBio, Vol 7, Iss 4 (2016)
mBio
mBio, Vol 7, Iss 4 (2016)
An arthropod-borne virus, Zika virus (ZIKV), has recently emerged as a major human pathogen. Associated with complications during perinatal development and Guillain-Barré syndrome in adults, ZIKV raises new challenges for understanding the molecular
Autor:
Katherine I. Young, Stephen S. Whitehead, Ebenezer Tumban, Erin E. Schirtzinger, Kathryn A. Hanley, Nyree E. Maes, Christopher T. Hanson
Publikováno v:
Journal of General Virology. 94:783-788
The genus Flavivirus includes both vector-borne and no known vector (NKV) species, but the molecular determinants of transmission mode are not known. Conserved sequence differences between the two groups occur in 5′ and 3′ UTRs. To investigate th
Autor:
Ruklanthi de Alwis, Aravinda M. de Silva, James E. Crowe, Nurgun Kose, Scott A. Smith, Stephen S. Whitehead, Anna P. Durbin
Publikováno v:
The Journal of Infectious Diseases. 207:1898-1908
The immunopathogenesis of severe dengue is poorly understood, but there is concern that induction of cross-reactive nonneutralizing antibodies by infection or vaccination may increase the likelihood of severe disease during a subsequent infection. We
Autor:
Tammy A. Romero, Brian R. Murphy, Stephen S. Whitehead, Neeraj S. Sathe, Christopher T. Hanson, Laura Goddard, Joseph E. Blaney, Kathryn A. Hanley
Publikováno v:
Vaccine. 26:817-828
The dengue virus type 3 (DENV-3) vaccine candidate, rDEN3Delta30, was previously found to be under-attenuated in both SCID-HuH-7 mice and rhesus monkeys. Herein, two strategies have been employed to generate attenuated rDEN3 vaccine candidates which
Publikováno v:
Journal of virology. 89(12)
The safety and efficacy of the live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine are attributed to mutations that accumulated in the viral genome during its derivation. However, little is known about the contribution that is made by
Autor:
Daniel H. Johnson, Brian R. Murphy, Cai-Yen Firestone, Jr . Joseph E. Blaney, Christopher T. Hanson, Stephen S. Whitehead
Publikováno v:
Journal of Virology. 75:9731-9740
A recombinant live attenuated dengue virus type 4 (DEN4) vaccine candidate, 2AΔ30, was found previously to be generally well tolerated in humans, but a rash and an elevation of liver enzymes in the serum occurred in some vaccinees. 2AΔ30, a non-tem
Publikováno v:
Virology. 289:283-296
The surface glycoproteins of viruses can play important roles in viral attachment, entry, and morphogenesis. Here, we investigated the role of the attachment G glycoprotein of human respiratory syncytial virus (RSV) in viral infection. RSV G is produ
Autor:
Peter L. Collins, Kathrin Schuldt, Ursula J. Buchholz, Harald Granzow, Stephen S. Whitehead, Brian R. Murphy
Publikováno v:
Journal of Virology. 74:1187-1199
We recently developed a system for the generation of infectious bovine respiratory syncytial virus (BRSV) from cDNA. Here, we report the recovery of fully viable chimeric recombinant BRSVs (rBRSVs) that carry human respiratory syncytial virus (HRSV)
Publikováno v:
Virology. 247:232-239
Respiratory syncytial virus (RSV) cpts 248/404 is a live-attenuated, temperature-sensitive ( ts ) vaccine candidate derived from cold-passaged cp RSV by two rounds of chemical mutagenesis and biological selection. Previous sequence analysis showed th