Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ryo, Ito"'
Publikováno v:
Biochemical and Biophysical Research Communications. 534:672-679
Aldosterone is synthesized in the adrenal by the aldosterone synthase CYP11B2. Although the control of CYP11B2 expression is important to maintain the mineral homeostasis, its overexpression induced by the depolarization-induced calcium (Ca2+) signal
Autor:
Tomomi Furihata, Yoshiyuki Yamaura, Ryo Ito, Kenta Umehara, Hidetaka Akita, Keita Kitamura, Hanae Morio, Takafumi Komori
Publikováno v:
Biologicalpharmaceutical bulletin. 44(7)
In vitro blood-brain barrier (BBB) models are essential research tools for use in developing brain-targeted drugs and understanding the physiological and pathophysiological functions of the BBB. To develop BBB models with better functionalities, thre
Autor:
Hiroki Shima, Ikuko Sato, Kazuhiko Igarashi, Koji Masuda, Akira Sugawara, Ryo Ito, Katsuhiko Shirahige, Hiroki Shimada, Atsushi Yokoyama
Publikováno v:
Endocrine journal. 68(4)
Angiotensin II (Ang II) is a well-known peptide that maintains the balance of electrolytes in the higher vertebrates. Ang II stimulation in the adrenal gland induces the synthesis of mineralocorticoids, mainly aldosterone, through the up-regulation o
Autor:
Shota Suzuki, Saki Izumi, Ken-ichi Nunoya, Takafumi Komori, Ryo Ito, Haruo Imawaka, Hidetaka Akita, Kenta Umehara, Keita Kitamura, Tomomi Furihata, Naomi Wakayama, Naohiko Anzai, Yoshiyuki Yamaura
Publikováno v:
Molecular pharmaceutics. 16(11)
Brain microvascular endothelial cells (BMEC), together with astrocytes and pericytes, form the blood-brain barrier (BBB) that strictly restricts drug penetration into the brain. Therefore, in central nervous system drug development, the establishment
Autor:
Nobuhiro Nishigaki, Hikaru Ueno, Yasufumi Miyamoto, Hirohisa Miyashita, Koji Takeuchi, Yoshiyuki Tsujihata, Minoru Maruyama, Ryo Ito, Hitomi Ogino, Yusuke Moritoh, Shin-ichi Abe
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222653 (2019)
PLoS ONE
PLoS ONE
GPR40/FFAR1 is a Gq protein-coupled receptor expressed in pancreatic β cells and enteroendocrine cells, and mediates insulin and incretin secretion to regulate feeding behavior. Several GPR40 full agonists have been reported to reduce food intake in
Autor:
Tapiwa, Lundu, Yoshimi, Tsuda, Ryo, Ito, Kenta, Shimizu, Shintaro, Kobayashi, Kentaro, Yoshii, Kumiko, Yoshimatsu, Jiro, Arikawa, Hiroaki, Kariwa
Publikováno v:
Biomedical research (Tokyo, Japan). 39(1)
Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) is a newly emerged phlebovirus identified in China, Japan, and South Korea. Phlebovirus glycoproteins (GP) play a key role in targeting viral structural components to the budding compart
Autor:
Keita Kitamura, Shota Suzuki, Hanae Morio, Naohiko Anzai, Kan Chiba, Hidetaka Akita, Kenta Umehara, Ryo Ito, Yoshiro Saito, Mari Hashimoto, Tomomi Furihata, Kosuke Saito
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 4, Pp 350-358 (2018)
Astrocytes have shown longstanding promise as therapeutic targets for various central nervous system diseases. To facilitate drug development targeting astrocytes, we have recently developed a new conditionally immortalized human astrocyte cell line,
Autor:
Kiyoshi Takagi, Jun Kanno, Atsushi Yokoyama, Akira Sugawara, Tetsuya Sato, Katsuhide Igarashi, Yasuyuki Ohkawa, Takashi Baba, Ryo Ito, Maky Otsuka, Yurina Shishido, Ken Ichirou Morohashi
Publikováno v:
Journal of Biological Chemistry. 289:18152-18162
Regulation of spatiotemporal gene expression in higher eukaryotic cells is critical for the precise and orderly development of undifferentiated progenitors into committed cell types of the adult. It is well known that dynamic epigenomic regulation (i
Autor:
Atsushi Yokoyama, Masataka Kudo, Kaori Sugawara, Sadayoshi Ito, Masahiro Nezu, William E. Rainey, Yuko Iki, Akiko Saito-Hakoda, Fumitoshi Satoh, Ryo Ito, Kyoko Shimizu, Akira Sugawara, Ken Matsuda, Ikuko Sato, Naotaka Kogure, Hiroki Shimada, Takeo Yoshikawa, Akira Uruno, Takako Saito-Ito
Publikováno v:
Molecular and cellular endocrinology. 383(1-2)
We generated a stable H295R cell line expressing aldosterone synthase gene (CYP11B2) promoter/luciferase chimeric reporter construct that is highly sensitive to angiotensin II (AII) and potassium, and defined AII receptor blocker (ARB) effects. In th
Autor:
Kazumasa Miyawaki, Kae Matsuda-Nagasumi, Koji Takeuchi, Yugo Habata, Hidetoshi Komatsu, Chiori Yabuki, Risa Maeda, Naoya Kikuchi, Kensuke Sakuma, Yoshiyuki Tsujihata, Masaaki Mori, Ryo Ito
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76280 (2013)
PLoS ONE
PLoS ONE
Selective free fatty acid receptor 1 (FFAR1)/GPR40 agonist fasiglifam (TAK-875), an antidiabetic drug under phase 3 development, potentiates insulin secretion in a glucose-dependent manner by activating FFAR1 expressed in pancreatic β cells. Althoug