Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Guangxun Meng"'
Autor:
Shanshan Yan, Ronghua Zhang, Qiaoshi Lian, Zhigang Tian, Hongbo Shen, Xiaoyu Sun, Guangxun Meng, Wenlong Jin, Zheng W. Chen, Wangpeng Gu, Xuan Lin, Bing Sun
Publikováno v:
The Journal of Immunology. 200:1016-1026
The nucleic acids of Mycobacterium tuberculosis can be detected by intracellular DNA sensors, such as cyclic GMP-AMP synthase and absent in melanoma 2 (AIM2), which results in the release of type I IFN and the proinflammatory cytokine IL-1β. However
Autor:
Jiajun Fan, Dianwen Ju, Wei Chen, Yichen Wang, Yanxu Liang, Yanyang Nan, Jingyun Luan, Xuyao Zhang, Guangxun Meng
Publikováno v:
Nanoscale. 10:9141-9152
Increased biomedical applications of mesoporous silica nanoparticles (MSNs) raise considerable attention concerning their toxicological effects; the toxicities of MSNs are still undefined and the underlying mechanisms are unknown. We conducted this s
Autor:
Qiuhong Guo, Guiwen Yang, Guangxun Meng, Guang Xue, Xiaomin Yao, Liguo An, Yue Xing, Hua Li, Yan Zhang
Publikováno v:
The Journal of Immunology. 199:1561-1566
NLRP3 inflammasome activiation requires two sequential signals. The priming signal 1 from TLRs or cytokine receptors induces the transcription of NLRP3 and IL-1β, and concomitantly promotes transcription-independent activation of caspase-1. The acti
Autor:
Dandan Li, Chan Ding, Lei Tan, Liao Ying, Cuiping Song, Yang Wang, Chunchun Meng, Yuan Zhan, Binbin Wang, Mao Xiang, Jie Zhu, Xusheng Qiu, Guangxun Meng, Yingjie Sun
Publikováno v:
Virology. 496:90-96
Inflammatory responses are important aspects of the innate immune system during virus infection. We found that Newcastle disease virus can induce inflammasome activation in the human macrophage-like cell line THP-1. Viral replication was required for
Autor:
Guang Xue, Hongbin Wang, Shuxian Wu, Yongfen Xu, Yao Fujia, Ailing Lu, Junling Niu, Jin Zhong, Zheng Li, Mengmeng Cui, Guangxun Meng
Publikováno v:
Antiviral Research. 172:104607
Simeprevir was developed as a small molecular drug targeting the NS3/4A protease of hepatitis C virus (HCV). Unexpectedly, our current work discovered that Simeprevir effectively promoted the transcription of IFN-β and ISG15, inhibited the infection
Autor:
Guangxun Meng, Mingkuan Chen, Wei Fang, Ailing Lu, Zhenzong Fa, Wanqing Liao, Bing Sun, Caiqin Guo, Changbin Chen
Publikováno v:
Microbes and Infection. 16:845-854
Cryptococcus neoformans (C. neoformans) is an opportunistic fungal pathogen that mainly infects immunocompromised individuals such as AIDS patients. Although cell surface receptors for recognition of C. neoformans have been studies intensively, cytop
Autor:
Hongbin Wang, Junling Niu, Qibin Leng, Li-Ping Zhu, Liming Mao, Wei Chen, Cunshuan Xu, Mingkuan Chen, Guowei Lei, Hua Li, Ailing Lu, Bin Xu, Guiwen Yang, Shuxian Wu, Guangxun Meng, Liguo An
Publikováno v:
Cell Research. 23:965-968
Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome
Autor:
Peter B. Luppa, Alina Grabiec, Stefan Bauer, Guangxun Meng, Jochen Metzger, Hermann Wagner, Carsten J. Kirschning, Mark Rutz
Publikováno v:
Immunology Letters. 98:200-207
Cellular recognition of immuno-stimulatory microbial products alarming the host immune system upon infection, as well as endogenous molecular patterns representing perturbation of regular homeostasis such as through necrosis of host cells is mediated
Autor:
Guangxun Meng, Hua Li, Wei Chen, Yongfen Xu, Junqi Niu, Bing Huang, Yu Xiang, Wanyin Tao, Jin Zhong
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e84953 (2014)
PLoS ONE, Vol 9, Iss 1, p e84953 (2014)
Background Elevated plasma levels of IL-1β and IL-18 from patients with hepatitis C virus (HCV) infection indicate a possible activation of inflammasome by HCV. Methodology/Principal Findings To demonstrate whether HCV infection activates the inflam
Publikováno v:
Innate immunity. 20(3)
Defensins are the first endogenous mediators to be characterized as alarmins and play multifunctional roles in immune response. Previous studies reported that human neutrophil peptide (HNP)-1, a member of the α-defensin subfamily, could regulate the