Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Geert J. P. L. Kops"'
Autor:
Sjoerd J. Klaasen, My Anh Truong, Richard H. van Jaarsveld, Isabella Koprivec, Valentina Štimac, Sippe G. de Vries, Patrik Risteski, Snježana Kodba, Kruno Vukušić, Kim L. de Luca, Joana F. Marques, Elianne M. Gerrits, Bjorn Bakker, Floris Foijer, Jop Kind, Iva M. Tolić, Susanne M. A. Lens, Geert J. P. L. Kops
Publikováno v:
Nature
Nature, 607, 604-609
Nature, 607, pp. 604-609
Nature, 607(7919), 604-609. Nature Publishing Group
Nature, 607, 604-609
Nature, 607, pp. 604-609
Nature, 607(7919), 604-609. Nature Publishing Group
Chromosome segregation errors during cell divisions generate aneuploidies and micronuclei, which can undergo extensive chromosomal rearrangements such as chromothripsis [1, 2, 3, 4, 5]. Selective pressures then shape distinct aneuploidy and rearrange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaaba46aeec6daf7ebdc7fd431951dd
http://fulir.irb.hr/7580/
http://fulir.irb.hr/7580/
Autor:
Sjoerd J, Klaasen, My Anh, Truong, Richard H, van Jaarsveld, Isabella, Koprivec, Valentina, Štimac, Sippe G, de Vries, Patrik, Risteski, Snježana, Kodba, Kruno, Vukušić, Kim L, de Luca, Joana F, Marques, Elianne M, Gerrits, Bjorn, Bakker, Floris, Foijer, Jop, Kind, Iva M, Tolić, Susanne M A, Lens, Geert J P L, Kops
Publikováno v:
Nature. 607(7919)
Chromosome segregation errors during cell divisions generate aneuploidies and micronuclei, which can undergo extensive chromosomal rearrangements such as chromothripsis
Autor:
Ana C.F. Bolhaqueiro, Nizar Hami, Devanjali Dutta, Nobuo Sasaki, Onno Kranenburg, Judith Vivié, Marc van de Wetering, Peter M. Lansdorp, Robert G.J. Vries, Alexander van Oudenaarden, Geert J. P. L. Kops, Hans Clevers, Diana C.J. Spierings, Hugo J. Snippert, Ingrid Verlaan-Klink, Bas Ponsioen, Emre Kucukkose, Richard H. van Jaarsveld, Bjorn Bakker, Sjoerd J Klaasen, Floris Foijer, Sylvia F. Boj
Publikováno v:
Nature Genetics, 51(5), 824-834. Nature Publishing Group
Nature Genetics, 51(5), 824. Nature Publishing Group
Nature Genetics
Nature Genetics, 51(5), 824. Nature Publishing Group
Nature Genetics
Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are hallmarks of cancer in humans. A persistent high frequency of these errors (chromosomal instability (CIN)) is predicted to profoundly impact tumor evolution and thera
Autor:
Fabien Cubizolles, Jasmine M. Bracher, Erich A. Nigg, Tale Sliedrecht, Geert J. P. L. Kops, Conrad von Schubert
Publikováno v:
Cell reports
Cell Reports, Vol 12, Iss 1, Pp 66-78 (2015)
Cell Reports, Vol 12, Iss 1, Pp 66-78 (2015)
SummaryEqual mitotic chromosome segregation is critical for genome integrity and is monitored by the spindle assembly checkpoint (SAC). We have previously shown that the consensus phosphorylation motif of the essential SAC kinase Monopolar spindle 1
Autor:
Johannes L. Bos, Nannette Jelluma, Karel W. A. Wirtz, Tobias B. Dansen, Ronald J.A. Wanders, Geert J. P. L. Kops, Simone Denis, Boudewijn M.T. Burgering
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 1, Pp 81-88 (2004)
Journal of lipid research, 45(1), 81-88. American Society for Biochemistry and Molecular Biology Inc.
Journal of lipid research, 45(1), 81-88. American Society for Biochemistry and Molecular Biology Inc.
The SCP gene encodes two proteins, sterol carrier protein X (SCPx) and SCP2, that are independently regulated by separate promoters. SCPx has been shown to be the thiolase involved in the breakdown of branched-chain fatty acids and in the biosynthesi
Autor:
René H. Medema, Susanne M.A. Lens, Paul J. Coffer, Boudewijn M.T. Burgering, Geert J. P. L. Kops, Marie Stahl, Pascale F. Dijkers
Publikováno v:
The Journal of Immunology. 168:5024-5031
The cytokine IL-2 plays a very important role in the proliferation and survival of activated T cells. These effects of IL-2 are dependent on signaling through the phosphatidylinositol 3-kinase (PI3K) pathway. We and others have shown that PI3K, throu
Publikováno v:
Science, 333(6051), 1895-1898
Various types of chromosomal aberrations, including numerical (aneuploidy) and structural (e. g., translocations, deletions), are commonly found in human tumors and are linked to tumorigenesis. Aneuploidy is a direct consequence of chromosome segrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e882d75e9762a37fb21ebc965ff734
https://hdl.handle.net/1887/108539
https://hdl.handle.net/1887/108539
Autor:
Adrian T. Saurin, Susanne M.A. Lens, Geert J. P. L. Kops, René H. Medema, Maike S. van der Waal
Publikováno v:
Nature Communications
The mitotic checkpoint prevents mitotic exit until all chromosomes are attached to spindle microtubules. Aurora B kinase indirectly invokes this checkpoint by destabilizing incorrect attachments; however, a more direct role remains controversial. In
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 4, p e10251 (2010)
PLoS ONE, Vol 5, Iss 4, p e10251 (2010)
Background Proper execution of chromosome segregation relies on tight control of attachment of chromosomes to spindle microtubules. This is monitored by the mitotic checkpoint that allows chromosome segregation only when all chromosomes are stably at
Autor:
René H. Medema, Thijn R. Brummelkamp, Rob M. F. Wolthuis, Reuven Agami, Jos J. W. Kauw, Geert J. P. L. Kops, Susanne M.A. Lens, Rob Klompmaker
Publikováno v:
Embo journal, 22(12), 2934. Nature publishing group
Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive. We show that mammalian cells lacking survivin are unable to align their chromosomes, fail to recruit Aurora B to ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb88effc47a7603b6f8d0d397f5cd4b
https://dspace.library.uu.nl/handle/1874/7947
https://dspace.library.uu.nl/handle/1874/7947