Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Gary J. Nabel"'
Autor:
Bradford Elmer, Errin Roberts, Susan Ryan, Lei Guo, Kurt Swanson, Maria-Carmen Obinu, Dinesh S. Bangari, Pascal Barneoud, Peter A. Piepenhagen, Laurent Pradier, Gary J. Nabel, Bailin Zhang, Tatyana V. Taksir, Zhi Yong Yang
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226245 (2019)
PLoS ONE
PLoS ONE
Antibody therapies for Alzheimer's Disease (AD) hold promise but have been limited by the inability of these proteins to migrate efficiently across the blood brain barrier (BBB). Central nervous system (CNS) gene transfer by vectors like adeno-associ
Autor:
Daniel Lingwood, Adam K. Wheatley, Kevin B. Chandler, Hadi M. Yassine, Rina F. Villar, Masaru Kanekiyo, Jinal Patel, Catherine E. Costello, Grant C. Weaver, Adrian B. McDermott, Patrick M. Mctamney, John R. Mascola, Gary J. Nabel, Steven A. Carr
Publikováno v:
Nature
Scientific Reports
Scientific Reports
Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B cell receptor (BCR) activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a792af69d39aa776778d633a53ae4e0
https://hdl.handle.net/10576/4968
https://hdl.handle.net/10576/4968
Autor:
John R. Mascola, Masaru Kanekiyo, Daniel Lingwood, Grant C. Weaver, Gary J. Nabel, Rina F. Villar
Predicting immune responses before vaccination is challenging because of the complexity of the governing parameters. Nevertheless, recent work has shown that B cell receptor (BCR)-antigen engagement in vitro can prove a powerful means of informing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3606f9634147e28ebdce896ae9243f
https://europepmc.org/articles/PMC6956844/
https://europepmc.org/articles/PMC6956844/
Autor:
Srinivas S. Rao, Jason Hataye, Keyun Wang, Joseph P. Casazza, Tongqing Zhou, Lan Wu, Zhi Yong Yang, Amarendra Pegu, Wei Shi, Richard A. Koup, John Paul Todd, Peter D. Kwong, Gary J. Nabel, Ivelin S. Georgiev, Xiaoti Guo, Xuejun Chen, Mangaiarkarasi Asokan, Sijy O'Dell, John R. Mascola
Publikováno v:
Nature Communications
The treatment of AIDS with combination antiretroviral therapy (cART) remains lifelong largely because the virus persists in latent reservoirs. Elimination of latently infected cells could therefore reduce treatment duration and facilitate immune reco
Autor:
Jeffrey C. Boyington, Jonathan Abraham, Peter D. Kwong, Gary J. Nabel, Kwanyee Leung, Chantelle L. Hood
Publikováno v:
Journal of Virology. 84:2972-2982
Ebola virus (EBOV) cellular attachment and entry is initiated by the envelope glycoprotein (GP) on the virion surface. Entry of this virus is pH dependent and associated with the cleavage of GP by proteases, including cathepsin L (CatL) and/or CatB,
Autor:
Srinivas S. Rao, Rory Coffey, Gary J. Nabel, Michael S. Seaman, Wendy W. Yeh, John R. Mascola, Peter T. Hraber, Ayush Giri, James B. Whitney, Aravind Basavapathruni, Norman L. Letvin, Bette T. Korber
Publikováno v:
Journal of Virology. 84:953-963
The evolution of envelope mutations by replicating primate immunodeficiency viruses allows these viruses to escape from the immune pressure mediated by neutralizing antibodies. Vaccine-induced anti-envelope antibody responses may accelerate and/or al
Autor:
David Hawkes, Melissa K. Hill, Johnson Mak, John A Marshall, Caroline P Keating, Ann C. Palmenberg, Catherine Isel, Gary J. Nabel, Redmond P. Smyth, Shu-Yun Le, Roland Marquet
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2009, 37 (3), pp.945-56. ⟨10.1093/nar/gkn1015⟩
Nucleic Acids Research, Oxford University Press, 2009, 37 (3), pp.945-56. ⟨10.1093/nar/gkn1015⟩
International audience; The bias of A-rich codons in HIV-1 pol is thought to be a record of hypermutations in viral genomes that lack biological functions. Bioinformatic analysis predicted that A-rich sequences are generally associated with minimal l
Publikováno v:
Science
Influenza virus entry is mediated by the receptor binding domain (RBD) of its spike, the hemagglutinin (HA). Adaptation of avian viruses to humans is associated with HA specificity for α2,6- rather than α2,3-linked sialic acid (SA) receptors. Here,
Autor:
C. Richter King, Gary J. Nabel, Douglas E. Brough, Hedi Haddada, Franck Lemiale, Jason G. D. Gall
Publikováno v:
Vaccine. 25:2074-2084
Replication-defective adenovirus vectors, primarily developed from serotype 5 (Ad5) viruses, have been widely used for gene transfer and vaccination approaches. Vectors based on other serotypes of adenovirus could be used in conjunction with, or in p
Autor:
Alvin L. Smith, Kwanyee Leung, Jan Jongstra, Lakshmanan Ganesh, Jenny Jongstra-Bilen, Gary J. Nabel
Publikováno v:
The Journal of Experimental Medicine
Dendritic cells (DCs) capture and internalize human immunodeficiency virus (HIV)-1 through C-type lectins, including DC-SIGN. These cells mediate efficient infection of T cells by concentrating the delivery of virus through the infectious synapse, a