Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jan Tavernier"'
Autor:
Ralf Jockers, Jan Tavernier, Joris Wauman, Marine Luka, Julie Dam, Vincent Prevot, Tori Lhomme, Tangui Maurice, Lennart Zabeau, Erika Cecon, Anisia J. Silva, Min Min Chen
Publikováno v:
Neuroendocrinology
Neuroendocrinology, 2021, 111 (4), pp.370-387. ⟨10.1159/000508105⟩
Neuroendocrinology, 2021, 111 (4), pp.370-387. ⟨10.1159/000508105⟩
Introduction: Metabolic dysfunction is now recognized as a pivotal component of Alzheimer’s disease (AD), the most common dementia worldwide. However, the precise molecular mechanisms linking metabolic dysfunction to AD remain elusive. Objective: H
Functional Characterization of Naturally Occurring Pathogenic Mutations in the Human Leptin Receptor
Autor:
Jan Tavernier, I. Sadaf Farooqi, Frank Peelman, Xavier Prieur, Teresia Wangensteen, Stephen O'Rahilly, Wendy Kimber
Publikováno v:
Endocrinology. 149:6043-6052
We have recently reported the first naturally occurring missense mutations in the leptin receptor (LR) in patients with severe obesity. We have examined the molecular mechanisms by which these extracellular domain mutations disrupt LR signaling. The
Autor:
Anne-Sophie De Smet, Irma Lemmens, Joël Vandekerckhove, Annick Verhee, Jan Tavernier, Frank Peelman, Isabel Uyttendaele, Delphine Lavens
Publikováno v:
Molecular Endocrinology. 21:2821-2831
Binding of GH to its receptor induces rapid phosphorylation of conserved tyrosine motifs that function as recruitment sites for downstream signaling molecules. Using mammalian protein-protein interaction trap (MAPPIT), a mammalian two-hybrid method,
Autor:
Tim Vervliet, Vincenzo Sorrentino, Hristina Ivanova, Nael Nadif Kasri, Geert Bultynck, Giovanni Monaco, Jan B. Parys, Humbert De Smedt, Elke Decrock, Irma Lemmens, Elien Vandermarliere, Jan Tavernier, Luc Leybaert, Ludwig Missiaen, Lennart Martens
Publikováno v:
Scientific Reports, 5
Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports
SCIENTIFIC REPORTS
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca2+-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1d47068ee499032b868eb07aa47298
https://hdl.handle.net/2066/153911
https://hdl.handle.net/2066/153911
Autor:
Delphine Defeau, Hannes Iserentant, Lennart Zabeau, Jan Tavernier, Katrien Van Beneden, Dirk Elewaut, Peter Ulrichts, Annick Verhee, Dominiek Catteeuw, Frank Peelman
Publikováno v:
Journal of Biological Chemistry. 279:41038-41046
The leptin/leptin receptor system shows strong similarities to the long-chain cytokine interleukin-6 (IL-6) and granulocyte colony-stimulating factor cytokine/receptor systems. The IL-6 family cytokines interact with their receptors through three dif
Autor:
Sheng-Jiun Wu, Daniël Broekaert, Jan Tavernier, Iris Behrmann, Peter C. Heinrich, Lennart Zabeau, Joël Vandekerckhove, Annick Verhee, José Van der Heyden, Irwin Chaiken
Publikováno v:
European Journal of Immunology. 31:1087-1097
IL-5 is a major determinant in the survival, differentiation and effector-functions of eosinophils. It mediates its effect upon binding and activation of a membrane bound receptor (R), composed of a ligand-specific alpha-chain and a beta-chain, share
Autor:
José Van der Heyden, Geert Plaetinck, Jan Tavernier, Rene Devos, Louise H. Foley, J. E. Scheffler, Yves Guisez, Sigrid Cornelis
Publikováno v:
European Journal of Biochemistry. 225:635-640
Using a fusion protein of the human interleukin-5-receptor alpha chain (hIL5R alpha) and the human IgG C gamma 3 chain (hIL5R alpha-h gamma 3), we have developed a solid-phase assay for high-flux screening of a collection of synthetic compounds. We r
Autor:
Junichi Fujii, Benjamin G. Neel, Carola Verwijmeren, Onno Roovers, Judith Gits, Robert Karisch, Karishma Palande, Jan Tavernier, Ivo P. Touw, Yoshihito Iuchi
Publikováno v:
JOURNAL OF CELL SCIENCE
Journal of Cell Science, 124(21), 3695-3705. Company of Biologists Ltd
Journal of Cell Science, 124(21), 3695-3705. Company of Biologists Ltd
Reactive oxygen species (ROS) regulate growth factor receptor signalling at least in part by inhibiting oxidation-sensitive phosphatases. An emerging concept is that ROS act locally to affect signal transduction in different subcellular compartments
Autor:
Irwin Chaiken, Nicoleta J. Economou, Mark Contarino, Sabine Baxter, Monika Jost, Karyn McFadden, Patrick J. Loll, Gianfranco Pasut, Adrian E. Harrington, Meirav Zaks-Zilberman, Tetsuya Ishino, Sam Lievens, Jan Tavernier
Publikováno v:
Biochemistry. 50(35)
Human interleukin-5 receptor alpha (IL5R alpha) is a glycoprotein that contains four N-glycosylation sites in the extracellular region. Previously, we found that enzymatic deglycosylation of IL5R alpha resulted in complete loss of IL5 binding To loca
Autor:
Geert Plaetinck, S Cornelis, J. Vandekerckhove, J Van der Heyden, Jan Tavernier, Walter Fiers, Rene Devos
Publikováno v:
The EMBO Journal. 10:2133-2137
The mouse interleukin-5 receptor (mIL-5R) consists of two components one of which, the mIL-5R alpha-chain, binds mIL-5 with low affinity. Recently we demonstrated that monoclonal antibodies (Mabs) recognizing the second mIL-5R beta-chain, immunopreci