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Autor:
Oscar Ramos-Campoy, Albert Lladó, Beatriz Bosch, Mireia Ferrer, Agnès Pérez-Millan, Miguel Vergara, Laura Molina-Porcel, Laura Fort-Aznar, Ricardo Gonzalo, Fermín Moreno-Izco, Guadalupe Fernandez-Villullas, Mircea Balasa, Raquel Sánchez-Valle, Anna Antonell
Publikováno v:
Molecular Neurobiology. 59:6411-6428
Sporadic early-onset Alzheimer's disease (EOAD) and autosomal dominant Alzheimer's disease (ADAD) provide the opportunity to investigate the physiopathological mechanisms in the absence of aging, present in late-onset forms. Frontotemporal dementia (
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 286-294 (2022)
Activation of hepatic stellate cells (HSCs) causes hepatic fibrosis and results in chronic liver diseases. Although activated HSC functions are facilitated by an increase in the cytosolic Ca2+ concentration ([Ca2+]cyt), the pathophysiological roles o
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: We sought to determine how endothelial cell (EC) expression of the activating k-Ras (kirsten rat sarcoma 2 viral oncogene homolog) mutation, k-RasV12, affects their ability to form lumens and tubes and interact with pericytes during capill
Autor:
Xiaojia Guo, Leyuan Xu, Heino Velazquez, Tian-Min Chen, Ryan M. Williams, Daniel A. Heller, Barbara Burtness, Robert Safirstein, Gary V. Desir
Publikováno v:
J Am Soc Nephrol
Repeated administration of cisplatin causes CKD. In previous studies, we reported that the kidney-secreted survival protein renalase (RNLS) and an agonist peptide protected mice from cisplatin-induced AKI.To investigate whether kidney-targeted delive
Autor:
Almitra Rindiarti, Yasuhiro Okamoto, Shunsuke Nakagawa, Junko Hirose, Yuichi Kodama, Takuro Nishikawa, Yoshifumi Kawano
Publikováno v:
Leukemia & Lymphoma. 63:404-415
Drug resistance is a major problem in treatment with nelarabine, and its resolution requires elucidation of the underlying mechanisms. We established two nelarabine-resistant subclones of the human T-cell lymphoblastic leukemia cell line CCRF-CEM. Th
Publikováno v:
Nucleic Acids Research
The design of efficient and safe gene delivery vehicles remains a major challenge for the application of gene therapy. Of the many reported gene delivery systems, metal complexes with high affinity for nucleic acids are emerging as an attractive opti
Autor:
Alicia Roig-Merino, Manuela Urban, Matthias Bozza, Julia D. Peterson, Louise Bullen, Marleen Büchler-Schäff, Sina Stäble, Franciscus van der Hoeven, Karin Müller-Decker, Tristan R. McKay, Michael D. Milsom, Richard P. Harbottle
Publikováno v:
Stem Cell Reports
Summary The genetic modification of stem cells (SCs) is typically achieved using integrating vectors, whose potential integrative genotoxicity and propensity for epigenetic silencing during differentiation limit their application. The genetic modific
Autor:
Yaoyong Li, Samantha Carrera, Andrew D. Sharrocks, Karol Nowicki-Osuch, Shen Hsi Yang, Syed Murtuza Baker, David G. Spiller, Amanda O'Donnell
Publikováno v:
Nucleic Acids Research
Carrera, S, O'Donnell, A, Li, Y, Nowicki-Osuch, K, Yang, S-H, Baker, S M, Spiller, D & Sharrocks, A 2021, ' Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters. ', Nucleic Acids Res, vol. 49, no. 22, pp. 12744–12756 . https://doi.org/10.1093/nar/gkab1176
Carrera, S, O'Donnell, A, Li, Y, Nowicki-Osuch, K, Yang, S-H, Baker, S M, Spiller, D & Sharrocks, A 2021, ' Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters. ', Nucleic Acids Res, vol. 49, no. 22, pp. 12744–12756 . https://doi.org/10.1093/nar/gkab1176
High levels of histone acetylation are associated with the regulatory elements of active genes, suggesting a link between acetylation and gene activation. We revisited this model, in the context of EGF-inducible gene expression and found that rather
Autor:
Masa-Aki Ikeda, Khandakar A.S.M. Saadat, Zekiye Altan, Cuneyd Parlayan, Kaifee Arman, Yunus Sahin
Publikováno v:
Biochemical and Biophysical Research Communications. 585:89-95
Osteosarcoma (OS) is the most common primary malignant bone tumor which has unclear pathobiology. Hence, enlightening the exact molecular mechanism underlying osteosarcoma progression is crucial for developing new treatment strategies. One member of
Autor:
Parvaneh Soofian-kordkandi, Dariush Shanehbandi, Behzad Baradaran, Mahsa Javadian, Daniel Elieh Ali Komi, Najibeh Shekari, Tohid Kazemi
Publikováno v:
Clinical Nutrition ESPEN. 46:477-483
Docosahexaenoic acid (DHA) and linoleic acid (LA) have modulatory effects on breast cancer (BC) cell lines. We aimed to investigate the effects of DHA, LA alone, in combination, and in the presence of paclitaxel on the expression of five microRNAs in