Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Norman Sachs"'
Autor:
Andrea L. Richardson, Norman Sachs, Deborah A. Dillon, Joan S. Brugge, Carman Man-Chung Li, Ron C. J. Schackmann, Laura M. Selfors, Mackenzie Boedicker, Hendrik J. Kuiken, Jane E. Brock, G. Kenneth Gray, Judy Garber, Hans Clevers, Jennifer M. Rosenbluth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, 11(1). Nature Publishing Group
Nature Communications
Nature Communications, 11(1). Nature Publishing Group
Recently, organoid technology has been used to generate a large repository of breast cancer organoids. Here we present an extensive evaluation of the ability of organoid culture technology to preserve complex stem/progenitor and differentiated cell t
Publikováno v:
Development, 144(6), 1107-1112. Company of Biologists Ltd
Development (Cambridge), 144(6), 1107-1112. Company of Biologists Ltd
Development (Cambridge, England), 144(6), 1107. Company of Biologists Ltd
Development (Cambridge), 144(6), 1107-1112. Company of Biologists Ltd
Development (Cambridge, England), 144(6), 1107. Company of Biologists Ltd
Multiple recent examples highlight how stem cells can self-organize in vitro to establish organoids that closely resemble their in vivo counterparts. Single Lgr5+ mouse intestinal stem cells can be cultured under defined conditions forming ever-expan
Autor:
Ning Dai, Dongxi Xiang, Vladimir V. Botchkarev, Kelvin Xi Zhang, Anushka Dongre, Qing Chen, Norman Sachs, Ben Liu, Helena J. Randle, Hans Clevers, Zhe Li, Allison P. Clark, Ying Xie, David M. Livingston, Luwei Tao, Hua Wang, Aina He
Publikováno v:
Cell, 178(1), 135-151.e19. Elsevier B.V.
Cell
Cell
Loss of BRCA1 p220 function often results in basal-like breast cancer (BLBC), but the underlying disease mechanism is largely opaque. In mammary epithelial cells (MECs), BRCA1 interacts with multiple proteins, including NUMB and HES1, to form complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035fabaee94f6b0cd59cd83bc0e451d0
https://pure.knaw.nl/portal/en/publications/0c13fdbc-f487-49e0-b405-e868b174f1e3
https://pure.knaw.nl/portal/en/publications/0c13fdbc-f487-49e0-b405-e868b174f1e3
Autor:
Paloma Ordóñez-Morán, Maiia E. Bragina, Norman Sachs, Sonja Giger, Matthias P. Lutolf, Hans Clevers, Andrea Manfrin, Nikolce Gjorevski
Publikováno v:
Nature, 539(7630), 560-564. Nature Publishing Group
Epithelial organoids recapitulate multiple aspects of real organs, making them promising models of organ development, function and disease. However, the full potential of organoids in research and therapy has remained unrealized, owing to the poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fb5241bd8bbd61fcf2b6a591960b75
https://dspace.library.uu.nl/handle/1874/350458
https://dspace.library.uu.nl/handle/1874/350458
Publikováno v:
Proceedings of the National Academy of Sciences. 109:21468-21473
Progression through the various stages of skin tumorigenesis is correlated with an altered expression of the integrin α3β1, suggesting that it plays an important role in the tumorigenic process. Using epidermis-specific Itga3 KO mice subjected to t
Autor:
Peter, Buske, Jens, Przybilla, Markus, Loeffler, Norman, Sachs, Toshiro, Sato, Hans, Clevers, Joerg, Galle
Publikováno v:
The FEBS journal. 279(18)
In vitro culture of intestinal tissue has been attempted for decades. Only recently did Sato et al. [Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2
Publikováno v:
Journal of cell science. 122(Pt 2)
Re-epithelialization after skin wounding requires both migration and hyperproliferation of keratinocytes. Laminin-332 is deposited during migration over the provisional matrix. To investigate the function of the laminin-332 binding integrin alpha3bet