Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Haijing Wu"'
Autor:
Xiaofei Gao, Yang Song, Jiali Wu, Shuang Lu, Xiaoli Min, Limin Liu, Longyuan Hu, Meiling Zheng, Pei Du, Yaqin Yu, Hai Long, Haijing Wu, Sujie Jia, Di Yu, Qianjin Lu, Ming Zhao
Publikováno v:
Journal of Clinical Investigation. 132
The trace element iron affects immune responses and vaccination, but knowledge of its role in autoimmune diseases is limited. Expansion of pathogenic T cells, especially T follicular helper (Tfh) cells, has great significance to systemic lupus erythe
Publikováno v:
Clinical reviews in allergyimmunology. 63(3)
Germinal center (GC) reaction greatly contributes to the humoral immune response, which begins in lymph nodes or other secondary lymphoid organs after follicular B cells are activated by T-dependent antigens. The GCs then serve as a platform for foll
Publikováno v:
Autoimmunity. 53:56-64
Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in females of child-bearing age. It involves multiple systems and severely threatens human life. One of the typical characteristics of SLE is the formation of immune comple
Autor:
Qianwen Li, Zhidan Zhao, Hai Long, Haijing Wu, Di Long, Liwei Lu, Zhenghao He, Yunkai Guo, Longyuan Hu, Ming Yang, Qianjin Lu, Fen Li, Ming Zhao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-11 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Absent in melanoma 2 (AIM2) has been reported to be a component of inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and higher AIM2 expression is observed in the B cells from lupus patients. To date, the inflammasome-
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
As a subgroup of CD4+ T helper cells, follicular helper T (Tfh) cells provide help to germinal center B cells and mediate the development of long-lived humoral immunity. Dysregulation of Tfh cells is associated with several major autoimmune diseases.
Autor:
Longyuan Hu, Xiaoli Min, Qianjin Lu, Haijing Wu, Limin Liu, Sujie Jia, Linxuan Yang, Du Pei, Ming Zhao, Jiali Wu, Hai Long
Publikováno v:
Clinical Epigenetics
Background Transcription factor B cell lymphoma 6 (BCL6) is a master regulator of T follicular helper (Tfh) cells, which play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanisms by which BCL6 expression i
Autor:
Yu Guo, Haijing Wu, Qianjin Lu, Bochen Zhu, Aiyun Liu, Hai Long, Mengying Li, Qiao Peng, Yi Huang, Zijun Wang, Xiaofei Gao, Ming Zhao, Gongping Liang, Yixin Tan, Ruifang Wu, Cancan Huang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Epigenetic modifications affect the differentiation of T cell subsets and the pathogenesis of autoimmune diseases, but many mechanisms of epigenetic regulation of T cell differentiation are unclear. Here we show reduced expression of the transcriptio
Autor:
Xiaohui Wang, Yu Feng, Ming Zhao, Yaxiong Deng, Kongyang Ma, Liwei Lu, Di Long, Qianjin Lu, Haijing Wu
Publikováno v:
Cellular & Molecular Immunology. 15:676-684
B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated by autoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens and signals from help
Publikováno v:
Autoimmunity. 50:71-81
T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to B cells that drive class switch recombination, somatic hyper
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoimmune diseases are usually complex and multifactorial, characterized by aberrant production of autoreactive immune cells and/or autoantibodies against healthy cells and tissues. However, the pathogenesis of autoimmune diseases has not been clear