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Publikováno v:
Stem cells and development. 31(17-18)
Lineage-specific differentiation of human-induced pluripotent stem cells (hiPSCs) into cardiomyocytes (CMs) offers a patient-specific model to dissect development and disease pathogenesis in a dish. However, challenges exist with this model system, s
Publikováno v:
Aging. 14:9860-9876
Muscle mass decreases with aging, while the C-C motif chemokine ligand 2 (CCL2) increases with aging; in this context, CCL2 can be considered a potential aging-promoting factor. Thus, CCL2 knockout mice are expected to exhibit anti-aging effects incl
Autor:
Baur, Rachel, Kashon, Michael, Lukomska, Ewa, Weatherly, Lisa M., Shane, Hillary L., Anderson, Stacey E.
Publikováno v:
Journal of Immunotoxicology. 20:1-11
Triclosan is an anti-microbial chemical incorporated into products that are applied to the skin of healthcare workers. Exposure to triclosan has previously been shown to be associated with allergic disease in humans and impact the immune responses in
Autor:
Alasdair Cameron, Griffen Wakelin, Nicholas Gaulton, Laura V. Young, Scott Wotherspoon, Nathan Hodson, Matthew J. Lees, Daniel R. Moore, Adam P. Johnston
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1586-C1600
Skeletal muscle repair and maintenance are directly and indirectly supported by interstitial cell populations such as vascular cells and fibro-adipogenic progenitors (FAPs), a subset of which express Twist2 and possess direct myogenic potential. Furt
Publikováno v:
Journal of the Formosan Medical Association. 121:2446-2456
Recent emerging evidence indicates that dysfunction of metabolic remodeling underlies aberrant T cell immune responses in systemic lupus erythematosus (SLE). This study was undertaken to investigate the expression of HIF-1α, a regulator of metabolic
Autor:
Frances V. Sjaastad, Matthew A. Huggins, Erin D. Lucas, Cara Skon-Hegg, Whitney Swanson, Matthew D. Martin, Oscar C. Salgado, Julie Xu, Mark Pierson, Thamotharampillai Dileepan, Tamara A. Kucaba, Sara E. Hamilton, Thomas S. Griffith
Publikováno v:
The Journal of Immunology. 209:2149-2159
Successful vaccination strategies offer the potential for lifelong immunity against infectious diseases and cancer. There has been increased attention regarding the limited translation of some preclinical findings generated using specific pathogen-fr
Publikováno v:
Journal of Endodontics. 48:1493-1501
In this study, we generated a 3-dimensional (3D) collagen fibrous scaffold for potential pulp regeneration and investigated the influence of various pore sizes of these scaffolds on proliferation, odontoblastic differentiation of human dental pulp ce
Autor:
Ton, Mai-Linh Nu, Keitley, Daniel, Theeuwes, Bart, Guibentif, Carolina, Ahnfelt-Rønne, Jonas, Andreassen, Thomas Kjærgaard, Calero-Nieto, Fernando J, Imaz-Rosshandler, Ivan, Pijuan-Sala, Blanca, Nichols, Jennifer, Benito-Gutiérrez, Èlia, Marioni, John C, Göttgens, Berthold
Traditionally, the mouse has been the favoured vertebrate model for biomedical research, due to its experimental and genetic tractability. However, non-rodent embryological studies highlight that many aspects of early mouse development, such as its e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2ca864143efa141b8fcb59857ec512
Autor:
Xiuju Wu, Daoqin Zhang, Xiaojing Qiao, Li Zhang, Xinjiang Cai, Jaden Ji, Jocelyn A. Ma, Yan Zhao, John A. Belperio, Kristina I. Boström, Yucheng Yao
Publikováno v:
The European respiratory journal, vol 61, iss 6
Pulmonary fibrosis is a common and severe fibrotic lung disease with high morbidity and mortality. Recent studies have reported a large number of unwanted myofibroblasts appearing in pulmonary fibrosis, and shown that the sustained activation of myof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0b70c294ec4532e27c9d517ffaf701
https://escholarship.org/uc/item/8194999g
https://escholarship.org/uc/item/8194999g
Autor:
Shiwen Deng, Tong Lei, Hongyu Chen, Huiting Zheng, Zhuangzhuang Xiao, Shanglin Cai, Zhongci Hang, Weini Xiong, Yanqing Yu, Xiaoshuang Zhang, Yanjie Yang, Wangyu Bi, Hongwu Du
Publikováno v:
Cytotherapy. 24:1095-1104
Stem cells from human exfoliated deciduous teeth (SHED) play a significant role in tissue engineering and regenerative medicine. Angiogenesis is crucial in tissue regeneration and a primary target of regenerative medicine. As a first-line anti-diabet