Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ken-ichi Noma"'
Autor:
Takeshi Sakuno, Sanki Tashiro, Hideki Tanizawa, Osamu Iwasaki, Da-Qiao Ding, Tokuko Haraguchi, Ken-ichi Noma, Yasushi Hiraoka
Publikováno v:
Nucleic Acids Research. 50:3799-3816
During meiotic prophase, cohesin-dependent axial structures are formed in the synaptonemal complex (SC). However, the functional correlation between these structures and cohesion remains elusive. Here, we examined the formation of cohesin-dependent a
Autor:
Hideki Tanizawa, Rugang Zhang, Osamu Iwasaki, Andrew V. Kossenkov, Sanki Tashiro, Ken-ichi Noma, Louise C. Showe, Kyoung-Dong Kim, Sonali Majumdar, Timothy Nacarelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by global transcriptional alterations and 3D
Analysis of the 3D genomic organization of Schizosaccharomyces pombe during the cell cycle reveals that condensin mediates formation of large domains that serve as chromosomal compaction units, whereas cohesin forms smaller, more stable domains. Euka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d27a35ac1ffe527d12d10c00e8d8fb2
https://europepmc.org/articles/PMC5724045/
https://europepmc.org/articles/PMC5724045/
Autor:
Ken-ichi Noma
Publikováno v:
Annual review of genetics. 51
The three-dimensional (3D) genome structure is highly ordered by a hierarchy of organizing events ranging from enhancer–promoter or gene–gene contacts to chromosomal territorial arrangement. It is becoming clear that the cohesin and condensin com
Publikováno v:
Nature genetics
It is becoming clear that structural-maintenance-of-chromosomes (SMC) complexes such as condensin and cohesin are involved in three-dimensional genome organization, yet their exact roles in functional organization remain unclear. We used chromatin in
Publikováno v:
Molecular Biology of the Cell
The authors show that Pol III transcribed genes such as tRNA and 5S rRNA genes localize to centromeres in fission yeast. The centromeric localization of Pol III genes is mediated by condensin. This study suggests that there is a functional link betwe
Autor:
Kyoung-Dong Kim, Ken-ichi Noma, Atsunari Tanaka, Emmanuel Skordalakes, Hideki Tanizawa, Christopher J. Corcoran, Osamu Iwasaki, Yuhki Yokoyama, Louise C. Showe
Publikováno v:
Molecular cell. 59(5)
Genome/chromosome organization is highly ordered and controls various nuclear events, although the molecular mechanisms underlying the functional organization remain largely unknown. Here, we show that the TATA box-binding protein (TBP) interacts wit
Autor:
Ira M. Hall, Gurumurthy D. Shankaranarayana, Ken-ichi Noma, Nabieh Ayoub, Shiv I. S. Grewal, Amikam Cohen
Publikováno v:
Science. 297:2232-2237
The higher-order assembly of chromatin imposes structural organization on the genetic information of eukaryotes and is thought to be largely determined by posttranslational modification of histone tails. Here, we study a 20-kilobase silent domain at
Autor:
Eishi Noguchi, Ken-ichi Noma, Hideki Tanizawa, Mukund M. Das, Ya Ting Chang, Mariana C. Gadaleta, Toru Nakamura
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 3, p e1005943 (2016)
PLoS Genetics, Vol 12, Iss 3, p e1005943 (2016)
Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication stress, such as fork stalling and collapse, can be induced at natural replication impediments pre
Publikováno v:
Nature. 451(7177)
Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evolved defence mechanisms, including chromatin modifications and RNA interference, to regulate transposable elements. Here we describ