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pro vyhledávání: '"Myriam Lemmens"'
Autor:
Lindsey Rodrigues, Arne Mueller, Jasmin Haegele, Alberto Del Rio-Espinola, Silvana Libertini, Danilo Maddalo, Alex Odermatt, Benoit Fischer, Valerie Dubost, Alessandro Piaia, Myriam Lemmens, Ulla Plappert-Helbig, Grainne Kerr, Fanny Schaeffer, Ulrike Naumann, Hans-Jörg Martus, Michael Zogg
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 241-253 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 241-253 (2021)
Off-target editing is one of the main safety concerns for the use of CRISPR-Cas9 genome editing in gene therapy. These unwanted modifications could lead to malignant transformation, which renders tumorigenicity assessment of gene therapy products ind