Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mizue Terai"'
Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma
Autor:
Bao Quoc Lam, Takahito Sugase, Meggie Danielson, Mizue Terai, Andrew E. Aplin, Takami Sato, J. Silvio Gutkind
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Journal of Translational Medicine
Journal of Translational Medicine
Background Patients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of diverse MUM cell lines and appropriate animal models. We previously reported th
Autor:
Andrew E. Aplin, Hanyin Cheng, Mizue Terai, Takami Sato, Masahiro Ohara, Ken Kageyama, Kengo Saito
Publikováno v:
Cancers, Vol 13, Iss 1104, p 1104 (2021)
Cancers
Volume 13
Issue 5
Cancers
Volume 13
Issue 5
Uveal melanoma (UM) is the most common cancer of the eye in adults. Up to 50% of UM patients subsequently develop metastases, especially in the liver. It has been reported that the retinoblastoma (RB) pathway is deregulated in more than 90% of UM des
Autor:
Lihong Zhang, Mizue Terai, Eduardo F. Farias, Julio A. Aguirre-Ghiso, Clinita E. Randolph, Naiming Zhou, Takami Sato, Timothy J. Purwin, Philip B. Wedegaertner, Andrew E. Aplin, Gregory G. Tall, Shihua Wu, Dougan McGrath, Thomas H. Charpentier, Dominic Lapadula, Jeffrey L. Benovic
Publikováno v:
Molecular Cancer Research. 17:963-973
Uveal melanoma is the most common intraocular tumor in adults and often metastasizes to the liver, leaving patients with few options. Recurrent activating mutations in the G proteins, Gαq and Gα11, are observed in approximately 93% of all uveal mel
Autor:
Bao Lam, Eric Londin, Takami Sato, Emma O. Link, Ankit K. Rochani, Gagan Kaushal, Alok Bhushan, Mizue Terai, Marlana Orloff
Publikováno v:
Cancers
Volume 12
Issue 2
Cancers, Vol 12, Iss 2, p 405 (2020)
Volume 12
Issue 2
Cancers, Vol 12, Iss 2, p 405 (2020)
Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal melanoma (MUM) is highly resistant to immunotherapy. One of the mechanisms for resistance wou
Autor:
Mizue Terai, Paolo Fortina, Shinji Ozaki, Ken Kageyama, Andrew E. Aplin, Takami Sato, Kengo Saito, Masahiro Ohara, Michael J. Mastrangelo
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-19 (2017)
Journal of Translational Medicine
Journal of Translational Medicine
Background Metastatic uveal melanoma is a highly fatal disease; most patients die from their hepatic metastasis within 1 year. A major drawback in the development of new treatments for metastatic uveal melanoma is the difficulty in obtaining appropri
Autor:
Takami Sato, Michael J. Mastrangelo, Andrew E. Aplin, Mizue Terai, Raja Vuyyuru, Tim Manser, Shinji Ozaki, Hanyin Cheng, Masahiro Ohara, Ken Kageyama
Publikováno v:
The American Journal of Pathology. 186:43-56
Uveal melanoma (UM) is a rare type of melanoma, although it is the most common primary ocular malignant tumor in adults. Nearly one-half the patients with primary UM subsequently develop systemic metastasis, preferentially to the liver. Currently, no
Autor:
Nadezhda Anikeyeva, Melissa Wilson, Takahito Sugase, Yuri Sykulev, Mizue Terai, Takami Sato, Meggie Danielson, Bao Quoc Lam
Publikováno v:
Cancer Research. 79:2319-2319
Introduction: Metastatic uveal melanoma (MUM) is resistant to currently available treatments and overall prognosis is poor. MUM is an “immune cold” tumor and immune checkpoint blockades have only a marginal effect on this tumor. To bring immune c
Autor:
Ken Kageyama, Mizue Terai, Masahiro Ohara, Takami Sato, Hanyin Cheng, Andrew E. Aplin, Kengo Saito
Publikováno v:
Cancer Research. 78:2301-2301
Uveal melanoma (UM) is the most common cancer of the eye in adults. Up to 50% of UM patients subsequently develop metastases, especially in the liver, for which no effective treatment has been identified. It has been reported that the retinoblastoma
Autor:
Eiko Ohtsuka, Yutaka Tamura, Takami Sato, Michael J. Mastrangelo, David Berd, Mizue Terai, Vitali Alexeev
Publikováno v:
Cancer Immunology, Immunotherapy. 58:1307-1317
Interleukin 10 (IL-10) is produced by various types of human cancer, including malignant melanoma, and plays an important role in negative regulation of cell-mediated immune responses against tumors. We have developed chimeric molecules (immunoadhesi
Autor:
Michael J. Mastrangelo, Takami Sato, Mizue Terai, Kengo Saito, Ken Kageyama, Shinji Ozaki, Masahiro Ohara, Andrew E. Aplin
Publikováno v:
Cancer Research. 76:623-623
The prognosis of metastatic uveal melanoma (UM) is extremely poor. Approximately 90% of patients with metastatic UM die from hepatic metastasis. Controlling hepatic metastases has been a rational approach to extend survival. This raises an urgent nee