Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Fatemeh Momen-Heravi, Hiroshi Nakagawa, Satoshi Takada, Veena Sangwan, Norihiro Matsuura, Andres J. Klein-Szanto, Angela J. Yoon, Koji Tanaka, Samuel Flashner, Uma M. Sachdeva, Lorenzo E. Ferri, Masataka Shimonosono, Eishi Noguchi, J. Alan Diehl, Yasuto Tomita
Publikováno v:
Biomolecules, Vol 11, Iss 1479, p 1479 (2021)
Biomolecules
Volume 11
Issue 10
Biomolecules
Volume 11
Issue 10
Background: Alcohol (ethanol) consumption is a major risk factor for head and neck and esophageal squamous cell carcinomas (SCCs). However, how ethanol (EtOH) affects SCC homeostasis is incompletely understood. Methods: We utilized three-dimensional
Publikováno v:
Molecular Carcinogenesis. 56:1182-1188
Proprotein convertases (PCs) are serine proteases with an active role in the post-translational processing of numerous inactive proteins to active proteins including many substrates of paramount importance in cancer development and progression. Furin
Autor:
Ashley A. Lento, Hiroshi Nakagawa, Kensuke Suzuki, Qiaosi Tang, Mirazul Islam, Adam J. Bass, Anil K. Rustgi, Veronique Giroux, Gizem Efe, Apple Long, E. Paul Wileyto, Tatiana A. Karakasheva, Andres J. Klein-Szanto
Publikováno v:
EMBO Rep
Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer worldwide. The most commonly mutated gene in ESCC is TP53. Using a combinatorial genetic and carcinogenic approach, we generate a novel mouse model of ESCC expr
Autor:
Andres J. Klein-Szanto, Javier S. Castresana, Daniel E. Bassi, Gary Thomas, Ricardo Lopez de Cicco, Javier Mercapide
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(8)
Purpose: Astrocytoma arises in the central nervous system as a tumorof great lethality, in part because of the invasive potential of the neoplastic cells that are able to release extracellular matrix-degrading enzymes. Furin convertase activates seve
Autor:
Barbara Burtness, Linara Gabitova, Tetyana V. Bagnyukova, Gregory P. Adams, Kathy Q. Cai, Hanqing Liu, Yan Zhou, Ilya G. Serebriiskii, Anna Sukhanova, Gail E. Herman, Lisa E. Kratz, David Cunningham, Igor Astsaturov, Ranee Mehra, Richard I. Kelley, Diana Restifo, Erica A. Golemis, Andrey Gorin, Brian L. Egleston, Hui Zheng, Louis M. Weiner, Dong-Hua Yang, Anna S. Nikonova, Andres J. Klein-Szanto
Publikováno v:
Cancer Discovery. 3:96-111
Persistent signaling by the oncogenic EGF receptor (EGFR) is a major source of cancer resistance to EGFR targeting. We established that inactivation of 2 sterol biosynthesis pathway genes, SC4MOL (sterol C4-methyl oxidase–like) and its partner, NSD
Autor:
Shinya Ohashi, Mitsuteru Natsuizaka, Ross A. Kalman, Phyllis A. Gimotty, Andres J. Klein-Szanto, Seiji Naganuma, Momo Nakagawa, Douglas S. Darling, Meenhard Herlyn, Sotai Kimura, Hiroshi Itoh, Shingo Kagawa, J. Alan Diehl, Hiroshi Nakagawa, Devraj Basu
Publikováno v:
Cancer Research. 71:6836-6847
Zinc finger E-box–binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in TGF-β–mediated senescence, epithelial-to-mesenchymal transition (EMT), and cancer stem cell functions. ZEBs are negatively regulated by members of the
Autor:
Kiranmai Gumireddy, George Coukos, le Sage C, Reuven Agami, Dionyssios Katsaros, Mariette Schrier, David A. Egan, Phyllis A. Gimotty, Andres J. Klein-Szanto, Nair S, Remco Nagel, Guanghua Huang, Lin Zhang, Puré E, Qihong Huang, Anping Li
Publikováno v:
Nature Cell Biology. 10:202-210
MicroRNAs (miRNAs) are single-stranded, noncoding RNAs that are important in many biological processes1,2. Although the oncogenic and tumour-suppressive functions of several miRNAs have been characterized, the role of miRNAs in mediating tumour metas
Autor:
Munenori Takaoka, Carmen Z. Michaylira, Andres J. Klein-Szanto, Hiroshi Nakagawa, Claudia D. Andl, Douglas B. Stairs, Ben Rhoades, Seok-Hyun Kim, Wafik S. El-Deiry, Takaomi Okawa, Cameron N. Johnstone, James J. Lee
Publikováno v:
Cancer Biology & Therapy. 6:534-540
Insulin-like growth factor binding protein (IGFBP)-3 exerts either proapoptotic or growth stimulatory effects depending upon the cellular context. IGFBP-3 is overexpressed frequently in esophageal cancer. Yet, the role of IGFBP-3 in esophageal tumor
Autor:
Anil K. Rustgi, Munenori Takaoka, Claudia D. Andl, Brenton B. Fargnoli, Hiroshi Nakagawa, Andres J. Klein-Szanto, Xianxin Hua, Takaomi Okawa, Meenhard Herlyn, Mark Bowser
Publikováno v:
Cancer Research. 66:9878-9885
In epithelial cells, E-cadherin plays a key role in cell-cell adhesion, and loss of E-cadherin is a hallmark of tumor progression fostering cancer cell invasion and metastasis. To examine E-cadherin loss in squamous cell cancers, we used primary huma
Autor:
Nabil G. Seidah, Stanley Zucker, Andres J. Klein-Szanto, Daniel E. Bassi, Ricardo Lopez de Cicco
Publikováno v:
Cancer Research. 65:4162-4171
Furin, a potent proprotein convertase involved in activation of several cancer-related substrates, is synthesized as an inactive zymogen, thus minimizing the occurrence of premature enzymatic activity that would lead to inappropriate protein activati