Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Zhonghua Hu"'
Autor:
Zhonghua Hu, Zheng Li
Publikováno v:
Current Opinion in Neurobiology. 45:24-31
Synapses are functional units of the nervous system, through which information is transferred between neurons. The development and activity-dependent modification of synapses require temporally and spatially controlled modulation of gene expression.
Autor:
Ning Zhang, Guoliang Liu, Yeqiu Wang, Ren Yandong, Zhonghua Hu, Fang Geng, Zhibo Zhang, Xiuhong Wu
Publikováno v:
Cellular and Molecular Neurobiology. 38:549-557
Senile plaque accumulation and neurofibrillary tangles are primary characteristics of Alzheimer's disease. We aimed to assess the protective functions of naringenin against β-amyloid protein fragment 25-35 (Aβ25-35)-caused nerve damage in different
Autor:
Yang Li, Jennitte Stevens, Zhi Liu, Zhonghua Hu, Christopher Murawsky, Sally Yu Shi, Wei Yan, Mark Leo Michaels, William G. Richards, Jun Zhang, Vicki Wilson, Ya-Wen Lu
Publikováno v:
The Journal of Biological Chemistry
Bispecific antibodies have become important formats for therapeutic discovery. They allow for potential synergy by simultaneously engaging two separate targets and enable new functions that are not possible to achieve by using a combination of two mo
Publikováno v:
The Journal of Cell Biology
Expression of the Gria1-targeting miRNA miR-501-3p is increased locally in dendrites after NMDAR activation and is required for NMDAR-dependent inhibition of GluA1 expression and long-lasting spine shrinkage and elimination.
The number of α-ami
The number of α-ami
Autor:
Howard Monique L, Esther C. Leng, Nancy Sun, Vladimir I. Razinkov, Haruki Hasegawa, Clark Rutilio H, Janelle Stoops, William C. Fanslow, Zhi Liu, Min Shen, Kannan Gunasekaran, Zhonghua Hu, Martin Pentony, Kathy Manchulenko, Wei Yan, Ian Foltz, Hua Liu
Publikováno v:
Journal of Biological Chemistry. 290:7535-7562
Producing pure and well behaved bispecific antibodies (bsAbs) on a large scale for preclinical and clinical testing is a challenging task. Here, we describe a new strategy for making monovalent bispecific heterodimeric IgG antibodies in mammalian cel
Publikováno v:
The Journal of Neuroscience. 34:13725-13736
Dysbindinis a schizophrenia susceptibility gene required for the development of dendritic spines. The expression of dysbindin proteins is decreased in the brains of schizophrenia patients, and neurons in mice carrying a deletion in thedysbindingene h
Autor:
Cai Yun Chen, Marjan Gucek, Sanford P. Markey, Zhonghua Hu, Zheng Li, Yong Chen, Meng-Hsuan J. Han
Publikováno v:
Journal of Proteome Research
The gene DTNBP1 encodes the protein dysbindin and is among the most promising and highly investigated schizophrenia-risk genes. Accumulating evidence suggests that dysbindin plays an important role in the regulation of neuroplasticity. Dysbindin was
Autor:
Kannan Gunasekaran, Zhonghua Hu, Boxu Yan, Zac Yates, Hongxing Zhou, Randal R. Ketchem, Zhi Liu
Publikováno v:
Journal of Biological Chemistry. 285:18662-18671
Hydroxyl radicals induce hinge cleavage in a human IgG1 molecule via initial radical formation at the first hinge Cys(231) followed by electron transfer to the upper hinge residues. To enable engineering of a stable monoclonal antibody hinge, we inve
Autor:
Guohua Yang, Ruimin Huang, Yuelei Chen, Gengxi Hu, Zhonghua Hu, Liang Zhang, Lijian Hui, Xu Chen, Jianwei Zhai, Wei Mo
Publikováno v:
Molecular Cell. 31(5):695-707
Signal transducers and activators of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-gamma (IFN-gamma) stimulation. Phosphorylated STAT1 translocates into nucleus to initiate the transcription of IFN-gamma target gene
Autor:
Wei Mo, Zhonghua Hu, Liang Zhang, Ye Xu, Nengyin Sheng, Ying Xiao, Yibin Chen, Naihe Jing, Gengxi Hu, Chaochen Wang
Publikováno v:
Journal of cell science. 122(Pt 8)
Heparan sulfate proteoglycans (HSPGs) are required for various signaling pathways, one of which is the bone morphogenetic protein (BMP) signaling pathway. N-deacetylase/N-sulfotransferase-1 (NDST1) participates in synthesizing heparan sulfate (HS) ch