Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tohru Sugawara"'
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100811- (2021)
Summary: We recently demonstrated that the zygotic gene Zscan5b is involved in maintaining the genomic integrity of pluripotent stem cells (PSCs) during mitosis and that Zscan5b gene expression can prevent chromosomal abnormalities. Here, we provide
Externí odkaz:
https://doaj.org/article/307412d1808d4afbb8cc01cf6daea95c
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 15, Iss, Pp 1-9 (2020)
Regenerative Therapy, Vol 15, Iss, Pp 1-9 (2020)
Introduction Recent studies have revealed that microRNAs (miRNAs, miRs) are important for self-renewal, differentiation, and cellular reprogramming of somatic cells into induced pluripotent stem cells (iPSC); however, their functional roles and targe
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100811-(2021)
Summary We recently demonstrated that the zygotic gene Zscan5b is involved in maintaining the genomic integrity of pluripotent stem cells (PSCs) during mitosis and that Zscan5b gene expression can prevent chromosomal abnormalities. Here, we provide a
Autor:
Hidenori Akutsu, Kenji Miyado, Shoko Miyajima, Tohru Sugawara, Akari Nakamura, Yasunori Yoshimura, Jun Miyauchi, Toshio Hamatani, Seiji Ogawa, Mitsutoshi Yamada, Mamoru Tanaka, Akihiro Umezawa, Akihiro Nakamura, Hideki Tsumura, Yuichirou Harada, Ryuichiro Okawa, Reina Ooka
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1366-1379 (2019)
Summary: Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability. However, it is unclear how ZGA genes prevent mitotic errors. Here we show that knockout of the ZGA gene Zscan5b,
Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors
Autor:
Mahito Nakanishi, Manami Ohtaka, Koichiro Nishino, Masashi Toyoda, Hidenori Akutsu, Tohru Sugawara, Yoshikazu Arai, Mayu Yamazaki-Inoue, Akihiro Umezawa, Ken Takasawa, Ken Nishimura
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 9, Iss, Pp 71-78 (2018)
Regenerative Therapy, Vol 9, Iss, Pp 71-78 (2018)
Human induced pluripotent stem cells (iPSCs) are established by introducing several reprogramming factors, such as OCT3/4, SOX2, KLF4, c-MYC. Because of their pluripotency and immortality, iPSCs are considered to be a powerful tool for regenerative m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9157e1b981a74af739f0bafe06369c
https://doi.org/10.1101/355099
https://doi.org/10.1101/355099
Autor:
Gabriel R. Linares, Justin K. Ichida, Yingxiao Shi, Brandon B Ge, Yichen Li, Jacob Komberg, R. Jeroen Pasterkamp, Davide Trotti, Valerie Hennes, Leonard H. van den Berg, Nicole Koutsodendris, Jason A. Chen, Kaitlin P. Sandor, Vamshidhar R. Vangoor, Louise Menendez, Amy R. Nelson, Michael E. Ward, Tze-Yuan Cheng, Yaoming Wang, Phillip E. Woolwine, Wen-Hsuan Chang, Ketharini Senthilkumar, Kim A. Staats, Mickey Huang, Carina Seah, Alice Zhang, Chris Grunseich, Esther Y. Son, Eric Hendricks, Michael J. Cowan, Paul R. August, Kassandra Kisler, Shih Jong J. Lee, Marcelo P. Coba, Shu Ting Hung, Shaoyu Lin, Brent Wilkinson, N. Wisniewski, Berislav V. Zlokovic, Tohru Sugawara, T. Grant Belgard, Victor Hanson-Smith, Xinmei Wen
Publikováno v:
Nature Medicine, 24(3), 313. Nature Publishing Group
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using human induced motor neurons (iMNs), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7b18c3fd3677e0457e409e74f97ed0
https://dspace.library.uu.nl/handle/1874/364200
https://dspace.library.uu.nl/handle/1874/364200
Autor:
Kenji Miyado, Takumi Miura, Hidenori Akutsu, Masakazu Machida, Mohan C. Vemuri, Seiichi Kanzaki, Akihiro Umezawa, Mayu Yamazaki-Inoue, Tohru Sugawara, Mahendra S. Rao, Naoko Nakamura, Takashi Ohkura
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 1, Iss C, Pp 18-29 (2015)
Regenerative Therapy, Vol 1, Iss C, Pp 18-29 (2015)
The potential applications of human embryonic stem cells (hESCs) in regenerative medicine and developmental research have made stem cell biology one of the most fascinating and rapidly expanding fields of biomedicine. The first clinical trial of hESC
Publikováno v:
Stem Cell Investigation. 5:3-3
The gastrointestinal (GI) tract is a complex organ system derived from a simple hollow long tube generated in early human development. The GI tract is developed by a series of complex mutual interactions among several types of cells derived from all
Publikováno v:
Stem Cell Research & Therapy
Induced pluripotent stem (iPS) cells, obtained from reprogramming somatic cells by ectopic expression of a defined set of transcription factors or chemicals, are expected to be used as differentiated cells for drug screening or evaluations of drug to
Autor:
Justin K. Ichida, Takumi Miura, Hidenori Akutsu, Youki Takezawa, Toshio Hamatani, Tohru Sugawara, Naoaki Kuji, Keiichi Yoshida, Noriko Okumura, Kenji Miyado, Akihiro Umezawa, Yasunori Yoshimura, Mitsutoshi Yamada, Akihiro Hosoda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e63265 (2013)
PLoS ONE, Vol 8, Iss 5, p e63265 (2013)
The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance between proliferation and differentiation throughout embryogenesis and tissue homeostasis. β-Catenin, encoded by the Ctnnb1 gene, mediates an intra