Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Thomas Lehner"'
Autor:
Jonathan Warrell, Stamatios N. Sotiropoulos, Michael J. Gandal, Geetha Senthil, Justin T. Baker, Stefan Bekiranov, Jacob M. Taylor, Alán Aspuru-Guzik, Thomas Lehner, Matteo Bastiani, Aram W. Harrow, John D. Murray, Michael J. McConnell, Alan Anticevic, Prashant Emani, Guillermo Sapiro, Mark Gerstein
Publikováno v:
Nat Methods
The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e6b894abf5f9be5f976cfcf66f8701
http://arxiv.org/abs/1911.07127
http://arxiv.org/abs/1911.07127
Publikováno v:
Journal of Biological Chemistry. 287:17152-17160
The efficacy of a vaccine is generally dependent on an adjuvant, which enhances the immune functions and alum has been widely used in human immunization. Alum activates the intracellular stress sensors inflammasomes, but whether these are responsible
Publikováno v:
European Journal of Immunology. 40:1628-1638
Evidence is presented that thermal or oxidizing stress-activated DC interact with CD4(+) T cells to induce and maintain a TCR-independent homeostatic memory circuit. Stress-activated DC expressed endogenous intra-cellular and cell surface HSP70. The
Publikováno v:
Wang, Y, Lavender, P, Watson, J, Arno, M & Lehner, T 2015, ' Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15-and IL1β-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes ', Journal of Biological Chemistry, vol. 290, no. 25, pp. 15595-15609 . https://doi.org/10.1074/jbc.M115.645754
The prevailing evidence suggests that immunological memory does not require antigenic re-stimulation but is maintained by low level tonic stimulation. We examined the hypothesis that stress agents contribute to tonic cellular activation and maintain
Autor:
Justine Younson, Charles Kelly, Lesley A. Bergmeier, Barry Peters, Thomas Lehner, Trevor Whittall, Mahavir Singh, Yufei Wang
Publikováno v:
European Journal of Immunology. 36:2304-2314
Evidence is presented that the microbial 70-kD heat shock protein (HSP70) binds to CCR5 chemokine receptors in CCR5-transfected cell lines and in primary human cells. Significant CCR5-mediated calcium mobilization was stimulated by HSP70 and inhibite
Autor:
Thomas Lehner, Yufei Wang
Publikováno v:
Heat Shock Proteins ISBN: 9789400767867
Inducible HSP70 is the hallmark of cell stress and it may mediate CD4+ T cell memory and adjuvanticity. In vitro interaction between human DC exposed to thermal or oxidative stress and CD4+ T cells elicits homeostatic memory. The mechanism involves a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c17d9a10c91661b15b9bf3666d5a825a
https://doi.org/10.1007/978-94-007-6787-4_13
https://doi.org/10.1007/978-94-007-6787-4_13
Autor:
Irun R. Cohen, Brian Henderson, Willem van Eden, Anthony R.M. Coates, Thomas Lehner, A. Graham Pockley, Stuart K. Calderwood
In recent years, it has been hypothesised that a new signalling system may exist in vertebrates in which secreted molecular chaperones form a dynamic continuum between the cellular stress response and corresponding homeostatic physiological mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d281cb6acff9dee3225f4441e92cae9
https://europepmc.org/articles/PMC2866984/
https://europepmc.org/articles/PMC2866984/
Autor:
C. Kelly, L. J. Brady, J.K-C. Ma, Thomas Lehner, Lesley A. Bergmeier, S. F. Lee, P. Evans, W. Taylor, Arnold S. Bleiweis
Publikováno v:
Archives of Oral Biology. 35:S33-S38
The gene spa P (formerly designated as spa P1) encoding the Mr 185,000 surface antigen I/II of Streptococcus mutans, serotype c (strain NG5) has been sequenced. The deduced amino acid sequence of antigen I/II (1561 residues) includes a putative signa
Publikováno v:
Archives of Oral Biology. 35:S39-S45
Natural immunity to synthetic peptides (SP) derived from the sequences of a 3800 M r Streptococcus mutans antigen was found in human subjects. Significant serum IgG antibodies were detected both to the native streptococcal antigen and to the SP17, co
Autor:
Charles Kelly, Trevor Whittall, Lesley A. Bergmeier, Thomas Lehner, Kaboutar Babaahmady, Yufei Wang
Publikováno v:
Heat Shock Proteins: Potent Mediators of Inflammation and Immunity ISBN: 9781402055843
Heat shock proteins have a profound effect on the immune response. Extracellular uptake of antigen-bound HSP can be presented by both MHC class II and class I. Maturation of DC is stimulated by HSP, upregulating the costimulatory molecules CD40, CD80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d23d2bf7444e0870adc82b8ab649a4
https://doi.org/10.1007/978-1-4020-5585-0_11
https://doi.org/10.1007/978-1-4020-5585-0_11