Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Simon Lord"'
Autor:
Simon Lord-Dufour, Susan E. Quaggin, Yves Duroche, Michael Ryczko, Aftab Taiyab, Heather Sheardown, Jing Jin, Pan Liu, Emily Anne Hicks, Jason Baardsnes, Xinfang Xie
Publikováno v:
Biotechnology and Bioengineering. 118:423-432
Vascular leak is a key driver of organ injury in diseases, and strategies that reduce enhanced permeability and vascular inflammation are promising therapeutic targets. Activation of the angiopoietin-1 (ANG1)-Tie2 tyrosine kinase signaling pathway is
Autor:
Yves Durocher, Christian Gervais, Matthew Stuible, Sylvie Perret, Joseph D. Schrag, Simon Lord-Dufour, Gilles St-Laurent, Denis L'Abbé
Publikováno v:
Journal of Biotechnology
Highlights • CHO cells are more efficient than 293 cells for expressing trimeric SARS-CoV-2 spike protein. • A trimerization domain and elimination of the S1/S2 furin site are essential to obtain spike trimers. • Unprecedented trimeric spike ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e8b78819ea45a1160bc87f03606905
https://doi.org/10.1101/2020.09.08.286732
https://doi.org/10.1101/2020.09.08.286732
Autor:
Neel Patel, Lisa Ayers, Ioannis Roxanis, Luc Bidaut, Fredrik Karpe, Simon Lord, Mei Lin Ah-See, Christos E. Zois, Cameron Snell, Pankaj G. Roy, Christian Frezza, Leticia Campo, Adrian L. Harris, Francesca M. Buffa, Kevin M. Bradley, Ruth English, Fergus V. Gleeson, Tim James, R F Adams, Tom Metcalf, Syed Haider, Anand Sharma, Daniel R. McGowan, Dan Liu, Eugene J. Teoh, John D. Fenwick, Michael Pollak, Edoardo Gaude, Wei Chen Cheng, Simon Wigfield, Alastair M. Thompson
Publikováno v:
CELL METABOLISM
Cell Metabolism
Cell Metabolism
Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating measurement of marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a168f8387e5f05dbe5abffbe69c6fc
https://www.repository.cam.ac.uk/handle/1810/285637
https://www.repository.cam.ac.uk/handle/1810/285637
Autor:
Simon Wigfield, Michael J.O. Wakelam, Elena Favaro, Fredrik Karpe, Barrie Peck, Karim Bensaad, Katherine E. Pinnick, Adrian L. Harris, Francesca M. Buffa, Simon Lord, Ji-Liang Li, Qifeng Zhang, Jennifer Collins, Almut Schulze, Caroline A. Lewis
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 349-365 (2014)
Elsevier
Elsevier
Summary: An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were indu
Publikováno v:
Experimental Cell Research. 318:1586-1596
Several epidemiological studies have indicated that abundant consumption of foods from plant origin is associated with a reduced risk of developing several types of cancers. This chemopreventive effect is related to the high content of these foods in
Autor:
Jinane Doumit, Simon Lord-Dufour, Richard Béliveau, Carl Laflamme, Borhane Annabi, Karine Plouffe
Publikováno v:
Molecular Carcinogenesis. 49:710-717
Members of the low-density lipoprotein receptor-related protein (LRP) family are involved in metabolic stress and resistance phenotypes of cancer cells. New breakthroughs in brain cancer therapy have exploited that molecular signature and proved that
Autor:
Borhane Annabi, Martin Post, Chaitan Khosla, Louis-Charles Levros, Ian B. Copland, Jacques Galipeau, Simon Lord-Dufour, Eric Rassart, Abhirup Das
Publikováno v:
Stem Cells. 27:489-497
Mesenchymal stromal cell (MSC) markers are expressed on brain tumor-initiating cells involved in the development of hypoxic glioblastoma. Given that MSCs can survive hypoxia and that the glucose-6-phosphate transporter (G6PT) provides metabolic contr
Autor:
Jacques Galipeau, Simon Lord-Dufour, Jessica Cuerquis, Daniel L. Coutu, Ian B. Copland, Borhane Annabi, Eugenea Wang
Publikováno v:
Stem cells (Dayton, Ohio). 27(2)
Mesenchymal stromal cells (MSCs) display robust reparative properties through their ability to limit apoptosis, enhance angiogenesis, and direct positive tissue remodeling. However, low in vivo survival of transplanted cells limits their overall effe