Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ryo, Ito"'
Autor:
Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, Hyunmi Choi, Ge Yang, Yanan Zhao, Rei Yamaguchi, Hitomi Jin, Hina Sagae, Youichiro Wada, Toshiya Tanaka, Hiroshi Kimura, Tatsuhiko Kodama, Hiroyuki Aburatani, Kazuhisa Takeda, Takeshi Inagaki, Timothy F. Osborne, Takeshi Yoneshiro, Yoshihiro Matsumura, Juro Sakai
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109398- (2024)
Summary: Mitochondria play a vital role in non-shivering thermogenesis in both brown and subcutaneous white adipose tissues (BAT and scWAT, respectively). However, specific regulatory mechanisms driving mitochondrial function in these tissues have be
Externí odkaz:
https://doaj.org/article/04a6729f65d1452297c0ef6f43b6e818
Autor:
Yuta Tsujisaka, Takeshi Hatani, Chikako Okubo, Ryo Ito, Azuma Kimura, Megumi Narita, Kazuhisa Chonabayashi, Shunsuke Funakoshi, Antonio Lucena-Cacace, Taro Toyoda, Kenji Osafune, Takeshi Kimura, Hirohide Saito, Yoshinori Yoshida
Publikováno v:
Stem Cell Reports. 17:1772-1785
For regenerative cell therapies using pluripotent stem cell (PSC)-derived cells, large quantities of purified cells are required. Magnetic-activated cell sorting (MACS) is a powerful approach to collect target antigen-positive cells; however, it rema
Autor:
Kensuke, Sakuma, Noriko, Tsubooka-Yamazoe, Kiyohiro, Hashimoto, Nozomu, Sakai, Shinya, Asano, Saori, Watanabe-Matsumoto, Takeshi, Watanabe, Bunnai, Saito, Hirokazu, Matsumoto, Hikaru, Ueno, Ryo, Ito, Taro, Toyoda
Publikováno v:
Stem Cell Research & Therapy. 14
[Background] Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the safety of
Autor:
Mai Mochizuki, Sadafumi Kawamura, Kazuto Matsuura, Keiichi Tamai, Takayuki Imai, Wataru Iwai, Jun Yasuda, Akira Sugawara, Yukinori Asada, Makoto Abue, Tomoko Yamazaki, Haruna Fujimori, Rie Shibuya-Takahashi, Satoshi Saijoh, Ryo Ito, Yukio Katori, Mao Nakamura-Shima, Kazuo Sugamura, Kazunori Yamaguchi, Yu Katayose, Yuta Wakui, Kennichi Satoh
Publikováno v:
Biochemical and Biophysical Research Communications. 537:132-139
Cancer stem cells (CSCs) are believed to cause cancer metastasis and recurrence. BEX2 (brain expressed X-linked gene 2) is a CSC-related gene that is expressed in dormant CSCs in cholangiocarcinoma and induces resistance against chemotherapy. The aim
Publikováno v:
Biochemical and Biophysical Research Communications. 534:672-679
Aldosterone is synthesized in the adrenal by the aldosterone synthase CYP11B2. Although the control of CYP11B2 expression is important to maintain the mineral homeostasis, its overexpression induced by the depolarization-induced calcium (Ca2+) signal
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes
Autor:
Yuji Owada, Masayuki Kanamori, Kosuke Jozaki, Shuhei Kobayashi, Subrata Kumar Shil, Ryo Zama, Hiroshi Kogo, Ariful Islam, Kazuhiko Igarashi, Hirofumi Miyazaki, Chie Shimamoto-Mitsuyama, Yoshiteru Kagawa, Shin Ichiro Kanno, Banlanjo Abdulaziz Umaru, Shun Sato, Ryo Ito, Teiji Tominaga, Hiroki Shima, Akira Yasui, Kohji Fukunaga, Yui Yamamoto, Takeo Yoshikawa, Norihiro Sugino, Akira Sugawara
Publikováno v:
Molecular Neurobiology
Fatty acid binding protein 7 (FABP7) is an intracellular fatty acid chaperon that is highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported that FABP7 regulates the response to extracellular sti
Autor:
Toshiya Tanaka, Aoi Uchida, Takeshi Inagaki, Shogo Yamamoto, Tatsuhiko Kodama, Yoshihiro Matsumura, Ryo Ito, Yohei Abe, Youichiro Wada, Ryo Nakaki, Hiroyuki Aburatani, Koichi Node, Shuichi Tsutsumi, Rei Yamaguchi, Makoto Arai, Hitomi Fujihashi, Hiroki Takahashi, Ji Zhang, Kenta Magoori, Hiroyuki Hirakawa, Takeshi Kawamura, Hiroshi Kimura, Shin Ichi Inoue, Juro Sakai, Chaoran Yang, Ayumu Yajima, Timothy F. Osborne, Ge Yang, Satoshi Ota, Takeshi Yoneshiro
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Enhancer activation is essential for cell-type specific gene expression during cellular differentiation, however, how enhancers transition from a hypoacetylated “primed” state to a hyperacetylated-active state is incompletely understood. Here, we
Autor:
Tomomi Furihata, Yoshiyuki Yamaura, Ryo Ito, Kenta Umehara, Hidetaka Akita, Keita Kitamura, Hanae Morio, Takafumi Komori
Publikováno v:
Biologicalpharmaceutical bulletin. 44(7)
In vitro blood-brain barrier (BBB) models are essential research tools for use in developing brain-targeted drugs and understanding the physiological and pathophysiological functions of the BBB. To develop BBB models with better functionalities, thre
Autor:
Hiroki Shima, Ikuko Sato, Kazuhiko Igarashi, Koji Masuda, Akira Sugawara, Ryo Ito, Katsuhiko Shirahige, Hiroki Shimada, Atsushi Yokoyama
Publikováno v:
Endocrine journal. 68(4)
Angiotensin II (Ang II) is a well-known peptide that maintains the balance of electrolytes in the higher vertebrates. Ang II stimulation in the adrenal gland induces the synthesis of mineralocorticoids, mainly aldosterone, through the up-regulation o
Autor:
Shota Suzuki, Saki Izumi, Ken-ichi Nunoya, Takafumi Komori, Ryo Ito, Haruo Imawaka, Hidetaka Akita, Kenta Umehara, Keita Kitamura, Tomomi Furihata, Naomi Wakayama, Naohiko Anzai, Yoshiyuki Yamaura
Publikováno v:
Molecular pharmaceutics. 16(11)
Brain microvascular endothelial cells (BMEC), together with astrocytes and pericytes, form the blood-brain barrier (BBB) that strictly restricts drug penetration into the brain. Therefore, in central nervous system drug development, the establishment