Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Robert Landick"'
Publikováno v:
Nature
Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems. Broad-spectrum antibiotics eradicate the normal gut microbiome, killing protective commensal
Autor:
Robert Landick
Publikováno v:
Annual Review of Microbiology. 75:291-314
Cellular life depends on transcription of DNA by RNA polymerase to express genetic information. RNA polymerase has evolved not just to read information from DNA and write it to RNA but also to sense and process information from the cellular and extra
Autor:
Madeleine Delbeau, Expery O. Omollo, Ruby Froom, Steven Koh, Rachel A. Mooney, Mirjana Lilic, Joshua J. Brewer, Jeremy Rock, Seth A. Darst, Elizabeth A. Campbell, Robert Landick
Publikováno v:
Molecular Cell. 83:1474-1488.e8
Transcriptional pauses mediate regulation of RNA biogenesis. DNA-encoded pause signals trigger elemental pausing by stabilizing a half-translocated (RNA-not-DNA) state and by promoting RNAP swiveling that other factors can enhance. The universal tran
Autor:
Gene-Wei Li, Timothy T. Harden, Jeff Gelles, Jean-Benoît Lalanne, Jane Kondev, Ann Hochschild, Mathew Chamberlain, Karina S. Herlambang, Christopher D. Wells, Robert Landick
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
RNA polymerases (RNAPs) transcribe genes through a cycle of recruitment to promoter DNA, initiation, elongation, and termination. After termination, RNAP is thought to initiate the next round of transcription by detaching from DNA and rebinding a new
Publikováno v:
J Mol Biol
Journal of molecular biology, vol 431, iss 20
Journal of molecular biology, vol 431, iss 20
Pausing by RNA polymerase (RNAP) during transcription regulates gene expression in all domains of life. In this review, we recap the history of transcriptional pausing discovery, summarize advances in our understanding of the underlying causes of pau
Autor:
Beth A. Shen, Robert Landick
Publikováno v:
J Mol Biol
Decades of research have probed the interplay between chromatin (genomic DNA associated with proteins and RNAs) and transcription by RNA polymerase (RNAP) in all domains of life. In bacteria, chromatin is compacted into a membrane-free region known a
Autor:
Yu Bao, Robert Landick
Publikováno v:
Proc Natl Acad Sci U S A
The catalytic trigger loop (TL) in RNA polymerase (RNAP) alternates between unstructured and helical hairpin conformations to admit and then contact the NTP substrate during transcription. In many bacterial lineages, the TL is interrupted by insertio
Autor:
Jessica M. Vera, Joshua J. Coon, Robert Landick, Nagendra Prasad Kurumbang, Alexander S. Hebert
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0226235 (2020)
PLoS ONE
PLoS ONE
Plant-derived fuels and chemicals from renewable biomass have significant potential to replace reliance on petroleum and improve global carbon balance. However, plant biomass contains significant fractions of oligosaccharides that are not usable nati
Autor:
Daniel R Hron, Ramon A van der Valk, Liang Qin, Beth A Boudreau, Remus T. Dame, Robert Landick, Matthew V Kotlajich
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 46(11), 5525-5546
Nucleic Acids Research, 46(11), 5525-5546
In enterobacteria, AT-rich horizontally acquired genes, including virulence genes, are silenced through the actions of at least three nucleoid-associated proteins (NAPs): H-NS, StpA and Hha. These proteins form gene-silencing nucleoprotein filaments
Publikováno v:
Mol Cell
The bacterium, Francisella tularensis (Ft), is one of the most infectious agents known. Ft virulence is controlled by a unique combination of transcription regulators: the MglA-SspA heterodimer, PigR, and the stress signal, ppGpp. MglA-SspA assembles