Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mariano Severgnini"'
Autor:
Charlotte Abrecht, Margaret Hallisey, Jenna Dennis, Matthew Nazzaro, Martha Brainard, Emma Hathaway, Abigail N. Schork, F. Stephen Hodi, Mariano Severgnini, Joanna Baginska
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101362- (2022)
Summary: With the increasing use of mass cytometry in clinical research, a simplified and standardized protocol for immunophenotyping human peripheral blood mononuclear cells (PBMCs) in clinical trials is needed. We present a simplified in-plate stai
Externí odkaz:
https://doaj.org/article/71f8a2b5c4e5419b9c5012dd0f42c434
Autor:
Margaret Hallisey, Jenna Dennis, Charlotte Abrecht, Romanos Sklavenitis Pistofidis, Abigail N. Schork, Elizabeth D. Lightbody, Daniel Heilpern-Mallory, Mariano Severgnini, Irene M. Ghobrial, F. Stephen Hodi, Joanna Baginska
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101163- (2022)
Summary: This protocol details a staining technique optimized for immunophenotyping of human bone marrow immune populations using mass cytometry. The protocol accounts for the limitations of working with human bone marrow, such as reduced viability,
Externí odkaz:
https://doaj.org/article/742388b8e446429081c2e354f4ece9c6
Autor:
Margaret Hallisey, Jenna Dennis, Elizabeth P. Gabriel, Alyssa Masciarelli, Jiajia Chen, Charlotte Abrecht, Martha Brainard, William M. Marcotte, Han Dong, Emma Hathaway, Mubin Tarannum, Juliana A. Vergara, Abigail N. Schork, Kevin Tyan, Giuseppe Tarantino, David Liu, Rizwan Romee, Osama E. Rahma, Mariano Severgnini, F. Stephen Hodi, Joanna Baginska
Publikováno v:
Laboratory Investigation. :100174
Autor:
Matthew S. Davids, Robert J. Soiffer, Emma S. Hathaway, F. Stephen Hodi, Pavan Bachireddy, Magdalena Thurin, Vincent T. Ho, Wandi Zhang, Sarah Nikiforow, Nicoletta Cieri, Jerome Ritz, Stacey Gabriel, Mariano Severgnini, Aashna Jhaveri, X. Shirley Liu, Haesook T. Kim, Jingxin Fu, Kenneth J. Livak, Sacha Gnjatic, Scott J. Rodig, Alexandra Savell, Philippe Armand, Catherine J. Wu, Teddy Huang, Joseph H. Antin, Corey Cutler, Carrie Cibulskis, Livius Penter, Shuqiang Li, Howard Streicher, Donna Neuberg, Srinika Ranasinghe, Matthew Nazzaro, Yi Zhang, Emily M. Thrash, Helen X. Chen, John Koreth, Seunghee Kim-Schulze
Publikováno v:
Blood
Relapsed myeloid disease after allogeneic stem cell transplantation (HSCT) remains largely incurable. We previously demonstrated the potent activity of immune checkpoint blockade in this clinical setting with ipilimumab or nivolumab. To define the mo
Autor:
Christina M. Tringides, Mariano Severgnini, Waihay J. Wong, Georg N. Duda, Kwasi Adu-Berchie, Kai W. Wucherpfennig, Yutong Liu, Ann Mullally, Olga Pozdnyakova, Kyle H. Vining, Anna E. Marneth, David J. Mooney, Joshua M. Grolman, Alexander G. Stafford
Publikováno v:
Blood. 138:2539-2539
Myelofibrosis (MF) is a progressive, myeloid malignancy characterized by deposition of collagen and reticulin fibers in the bone marrow (BM). Previous studies have shown that monocytosis is associated with poor prognosis in MF, highlighting a potenti
Autor:
Mariano Severgnini, Martha Holland, Tara Patel, John F. Daley, Suzan Lazo, Amy Cunningham, F. Stephen Hodi
Publikováno v:
Cytotechnology. 70:1-11
The study of CD8 positive cells in peripheral blood has become an essential part of research in the field of cancer immunotherapies, vaccine development, inflammation, autoimmune disease, etc. In this study, an 8-color flow cytometry panel, containin
Autor:
Jacqueline S. Garcia, Howard Streicher, Michael K Keng, Robert J. Soiffer, Corey Cutler, Mariano Severgnini, Stephanie Andrews, Eric S. Winer, Matthew S. Davids, Jerome Ritz, Ryan C. Brennick, Yael Flamand, Marlise R. Luskin, Alexandra Savell, Ana Lako, Yohei Arihara, Claire Manuszak, Andreas Kantartzis, Richard Stone, Benjamin Tomlinson, Edwin P. Alyea, Vincent T. Ho, Nicole Cullen, Lillian Werner, Myrna Nahas, Pavan Bachireddy, David P. Steensma, R. Coleman Lindsley, Andrew M. Brunner, Catherine J. Wu, Scott J. Rodig, Martha Wadleigh, Samer K. Khaled, Donna Neuberg, Daniel J. DeAngelo, Ilene Galinsky
Publikováno v:
Blood. 134:2015-2015
Background: Patients (pts) with MDS or AML who relapse after allogeneic transplantation (allo-HCT) have a very poor prognosis. Hypomethylating agents (HMA) and checkpoint blockade with the anti-CTLA4 blocking antibody ipilimumab (IPI) have each induc
Autor:
Rachel Cunningham, Michael Manos, Ryan C. Brennick, Tara Patel, Martha Holland, Mariano Severgnini, Jun Zhou, Katja Kleinsteuber, F. Stephen Hodi, Amy Cunningham, Lake J. Seymour
Publikováno v:
Cell and tissue banking. 19(4)
Peripheral blood mononuclear cells (PBMCs) are essential to the study of autoimmune, infectious, parasitic diseases, and cancer. In the rapidly growing field of cancer immunology, cellular phenotyping provides critical information about patient respo
Autor:
Kristina Yucius, Ligang Zhang, Justin Aubin, Kevin Fitzgerald, Narayanannair K. Jayaprakash, Mariano Severgnini, Alfica Sehgal, Gang Wang, Chang G. Peng, James Butler, Jennifer Sherman
Publikováno v:
Cytotechnology. 64:187-195
Primary mouse hepatocytes are an important tool in the biomedical research field for the assessment of hepatocyte function. Several methods for hepatocyte isolation have been published; however, many of these methods require extensive handling and ca
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 295:L584-L592
Matrix metalloprotease-9 (MMP-9) is increased in lung injury following hyperoxia exposure in neonatal mice, in association with impaired alveolar development. We studied the role of MMP-9 in the mechanism of hyperoxia-induced functional and histologi