Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mandy L. Ford"'
Publikováno v:
American Journal of Transplantation. 20:2206-2215
Donor-reactive memory T cells generated via heterologous immunity represent a potent barrier to long-term graft survival following transplantation because of their increased precursor frequency, rapid effector function, altered trafficking patterns,
Autor:
Shunsuke Otani, Rebecca L. Crepeau, Jianfeng Xie, Mandy L. Ford, Ching-Wen Chen, Wenxiao Zhang, Craig M. Coopersmith
Publikováno v:
Journal of Leukocyte Biology. 105:565-575
Epstein–Barr virus (EBV) reactivation commonly occurs following sepsis, but the mechanisms underlying this are unknown. We utilized a murine EBV homolog (gHV) and the cecal ligation and puncture model of polymicrobial sepsis to study the impact of
Publikováno v:
iScience, Vol 23, Iss 4, Pp-(2020)
iScience
iScience
Summary Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells.
Autor:
Scott M. Krummey, Koichi Araki, Satomi Ando, Sara A. Guasch, Anna B. Morris, Weiwen Zhang, Christian P. Larsen, Jennifer Robertson, Katherine P. Tong, Jesica R. Jacobs, Brian D. Evavold, Haydn T. Kissick, Donald J. McGuire, Mandy L. Ford
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1282-1291.e5 (2020)
Summary: The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8+ T pool is unexpectedly comprised of both CD45RB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d1a6679e5fdaa0a65446604cd08445
https://europepmc.org/articles/PMC7155808/
https://europepmc.org/articles/PMC7155808/
Autor:
Paolo Cravedi, Clara R. Farley, Mark S. Cragg, Anna B. Morris, David F. Pinelli, Christopher D. Scharer, Layne E. Adams, Miguel Fribourg, Jeremy M. Boss, Mandy L. Ford, Peter S. Heeger
Effector CD8+ T cells are important mediators of adaptive immunity, and receptor-ligand interactions that regulate their survival may have therapeutic potential. Here, we identified a subset of effector CD8+ T cells that expressed the inhibitory frag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f883b2a890042dd5b19c0f8850e2c7ba
https://eprints.soton.ac.uk/437211/
https://eprints.soton.ac.uk/437211/
Autor:
Shunsuke Otani, Zhe Liang, John D. Lyons, Craig M. Coopersmith, Rohit Mittal, Mandy L. Ford, Nathan J. Klingensmith
Publikováno v:
The FASEB Journal. 31:5507-5519
Cell production and death are tightly regulated in the rapidly renewing gut epithelium, with proliferation confined to crypts and apoptosis occurring in villi and crypts. This study sought to determine how stress alters these compartmentalized proces
Autor:
Christian P. Larsen, Sara A. Guasch, Maylene E. Wagener, Scott M. Krummey, Ching wen Chen, Danya Liu, Mandy L. Ford
Publikováno v:
The Journal of Immunology. 197:2009-2015
The affinity of a TCR binding to peptide:MHC profoundly impacts the phenotype and function of effector and memory cell differentiation. Little is known about the effect of low-affinity priming on memory cell generation and function, which is particul
Autor:
Mandy L. Ford
Publikováno v:
Immunity. 44:1020-1033
The ultimate outcome of alloreactivity versus tolerance following transplantation is potently influenced by the constellation of cosignaling molecules expressed by immune cells during priming with alloantigen, and the net sum of costimulatory and coi
Publikováno v:
The FASEB Journal. 34:1-1
We recently showed that 2B4 expression on memory T cells in human renal transplant recipients was associated with reduced rates of rejection. To investigate whether 2B4 functionally underlies graft acceptance during transplantation, we established an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa656f8a0ab58a6acb2ccd39784b534
https://europepmc.org/articles/PMC6103805/
https://europepmc.org/articles/PMC6103805/