Zobrazeno 1 - 10
of 378
pro vyhledávání: '"Komuro, A."'
Autor:
Jin Komuro, Yuta Tokuoka, Tomohisa Seki, Dai Kusumoto, Hisayuki Hashimoto, Toshiomi Katsuki, Takahiro Nakamura, Yohei Akiba, Thukaa Kuoka, Mai Kimura, Takahiro Yamada, Keiichi Fukuda, Akira Funahashi, Shinsuke Yuasa
Publikováno v:
Biochemical and Biophysical Research Communications. 632:181-188
The number of patients with heart failure and related deaths is rapidly increasing worldwide, making it a major problem. Cardiac hypertrophy is a crucial preliminary step in heart failure, but its treatment has not yet been fully successful. In this
Autor:
Shun Nakamura, Genri Numata, Toshihiro Yamaguchi, Hiroyuki Tokiwa, Yasutomi Higashikuni, Seitaro Nomura, Tetsuo Sasano, Eiki Takimoto, Issei Komuro
Publikováno v:
Biochemical and Biophysical Research Communications. 637:247-253
Dopamine D1 receptor (D1R), coded by the Drd1 gene, is induced in cardiomyocytes of failing hearts, triggering heart failure-associated ventricular arrhythmia, and therefore could be a potential therapeutic target for chronic heart failure. The regul
Autor:
Mariko Komuro, Hinano Mizugaki, Masaki Nagane, Misako Morimoto, Tomoki Fukuyama, Kikumi Ogihara, Yuko Naya, Emi Yokomori, Kimika Kaneshima, Yasushi Kawakami, Junichi Kamiie, Yuki Shibata, Mira Suzuki, Takuto Shimizu, Nagako Kawashima, Mariko Okamoto, Teruo Ikeda, Tadashi Yamashita
Publikováno v:
The FEBS Journal.
Autor:
Jian Wu, Cheng Yang, Jun Ren, Xiangdong Yang, Hiroshi Akazawa, Guoping Zhang, Chunjie Yang, Komuro Issei, Yunzeng Zou, Ning Zhou, Le Kang, Li Lin, Qi Wang, Xiaoyan Wang, Yunqin Chen, Ruizhen Chen, Junbo Ge, Hong Jiang, Aijun Sun, Hui Gong
Publikováno v:
Journal of Molecular and Cellular Cardiology. 162:110-118
It is well known that lectin-like oxidized low-density lipoprotein (ox-LDL) and its receptor LOX-1, angiotensin II (AngII) and its type 1 receptor (AT1-R) play an important role in the development of cardiac hypertrophy. However, the molecular mechan
Autor:
Nobuhito Saito, Akiyoshi Komuro, Daizo Koinuma, Ryo Tanabe, Kohei Miyazono, Masato Morikawa, Satoshi Sakai, Erna Raja, Caname Iwata, Carl-Henrik Heldin, Tomoki Todo, Bengt Westermark
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 269-288 (2022)
Molecular Oncology, Vol 16, Iss 1, Pp 269-288 (2022)
Glioma‐initiating cells (GICs), a major source of glioblastoma recurrence, are characterized by the expression of neural stem cell markers and the ability to grow by forming nonadherent spheres under serum‐free conditions. Bone morphogenetic prot
Autor:
Shungo Hikoso, Kiyoshi Masuyama, Jun Li, Yuki Kuramoto, Shuichiro Higo, Shigeru Miyagawa, Akihito Hashimoto, Issei Komuro, Yoshiki Sawa, Atsuhiko T. Naito, Yasushi Sakata, Hideki Yasutake, Jong-Kook Lee, Kyoko Hidaka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration accompanied by dilated cardiomyopathy. Recently, abnormality of yes-associated protein (YAP) has been reported as the pathogenesis of muscle degeneration of DMD; ho
Autor:
Hiroaki Komuro, Anshu Malik, Shakhlo Aminova, Nathaniel Pascual, Yuki Kawai-Harada, Christopher H. Contag, Masako Harada
Publikováno v:
Nanotheranostics. 5:378-390
Extracellular vesicles (EVs) are naturally released, cell-derived vesicles that mediate intracellular communication, in part, by transferring genetic information and, thus, have the potential to be modified for use as a therapeutic gene or drug deliv
Publikováno v:
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology, Vol 11, Iss 1, Pp 1685-1692 (2020)
Beilstein Journal of Nanotechnology, Vol 11, Iss 1, Pp 1685-1692 (2020)
Gene therapy has been explored as a future alternative for treating heart disease. Among several gene delivery systems aimed at penetrating specific target cells, we focused on safe and non-viral gene delivery materials with a high transfection effic
Autor:
Masato Kanda, Toshio Nagai, Naomichi Kondo, Katsuhisa Matsuura, Hiroshi Akazawa, Issei Komuro, Yoshio Kobayashi
Publikováno v:
Cell Transplantation. 32:096368972311740
Many studies have explored cardiac progenitor cell (CPC) therapy for heart disease. However, optimal scaffolds are needed to ensure the engraftment of transplanted cells. We produced a three-dimensional hydrogel scaffold (CPC-PRGmx) in which high-via
Autor:
K. Sawada, Y. Hamaguchi, N. Numata, K. Mizumaki, K. Oishi, S. Maeda, Y. Ikawa, A. Komuro, K. Takehara, T. Matsushita
Publikováno v:
Journal of Investigative Dermatology. 142:S185