Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kiyonaga Fujii"'
Autor:
Norihito Shibata, Mikihiko Naito, Takahito Ito, Yuta Yanase, Yasushi Saeki, Kengo Hamamura, Kiyonaga Fujii, Hidetomo Yokoo, Yosuke Demizu, Yuki Murakami, Akinori Endo, Kosuke Aritake
Publikováno v:
Journal of Medicinal Chemistry. 64:15868-15882
Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It is important to select an appropriate linker, an E3 ligase ligand, and a target protein ligand in
Autor:
Hiroyuki Kimura, Saeko Naruki, Toshihide Nishimura, György Marko-Varga, Masayuki Takagi, Hiroki Sakai, Tomoyuki Miyazawa, Kiyonaga Fujii, Harubumi Kato, Hisashi Saji, Haruhiko Nakamura, Naoki Furuya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
No therapeutic targets have been identified for lung squamous cell cancer (SqCC) which is the second most prevalent lung cancer because its molecular profiles remain unclear. This study aimed to unveil disease-related protein networks by proteomic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa1c9bec483ad7f8260474d7932c153
https://doi.org/10.21203/rs.3.rs-798490/v1
https://doi.org/10.21203/rs.3.rs-798490/v1
Autor:
Takako Ooshio, Kenji Watanabe, Yoko Okada, Akira Suzuki, Kiyonaga Fujii, Bing Xin, Masahiro Yamamoto, Masanori Goto, Yuji Nishikawa, Josef M. Penninger, Hiroshi Nishina
Publikováno v:
Hepatology (Baltimore, Md.)
BACKGROUND AND AIMS Mitogen-activated protein kinase kinase (MKK) 7 and MKK4 are upstream activators of c-Jun NH2 -terminal kinases (JNKs) and have been shown to be required for the early development of the liver. Although it has been suggested that
Autor:
Masayuki Takagi, Kien Thiam Tan, Saeko Naruki, Shu-Jen Chen, Harubumi Kato, Hisashi Saji, Kiyonaga Fujii, Hirotaka Koizumi, Toshihide Nishimura, Haruhiko Nakamura, De-Wei Zhuo, Yasufumi Kato, Naoki Furuya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
The tumourigenesis of early lung adenocarcinomas, including adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and lepidic predominant invasive adenocarcinoma (LPA), remains unclear. This study aimed to capture disease-related mol
Autor:
Haruhiko Nakamura, Hisashi Saji, Ayako Yachie, Takeshi Hase, Toshihide Nishimura, Saeko Naruki, Harubumi Kato, Masayuki Takagi, Kiyonaga Fujii, Hirotaka Koizumi, Yukiko Matsuoka, Naoki Furuya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
It is unclear how epidermal growth factor receptor EGFR major driver mutations (L858R or Ex19del) affect downstream molecular networks and pathways. This study aimed to provide information on the influences of these mutations. The study assessed 36 p
Publikováno v:
Journal of Proteomics. 73:1196-1203
Interferon regulatory factor 3 (IRF-3) is a critical transcription factor that regulates innate immune responses against viral infection. Upon infection, IRF-3 is activated through phosphorylation of Ser/Thr residues in its C-terminal domain by the k
The Proteomic Profile of Pancreatic Cancer Cell Lines Corresponding to Carcinogenesis and Metastasis
Publikováno v:
Journal of Proteomics & Bioinformatics. :001-018
To investigate the proteomic background of the carcinogenesis and progression of pancreatic cancer, the protein expression profiles of nine well-characterized pancreatic adenocarcinoma cell lines, whose metastatic potential was previously examined in
Autor:
Takao Itoi, Kiyonaga Fujii, Tadashi Kondo, Tatsuhiko Kakisaka, Setsuo Hirohashi, Tatsuya Aoki, Tesshi Yamada, Toshihide Nishimura, Tetsuya Okano, Mitsufumi Endo, Akihiko Tsuchida, Fuminori Moriyasu, Satoru Todo, Kazufumi Honda, Harubumi Kato
Publikováno v:
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
We investigated the aberrant expression of plasma proteins in patients with pancreatic cancer. High-abundance plasma proteins (albumin, transferrin, haptoglobin, alpha-1-antitrypsin, IgG and IgA) were depleted by use of an immuno-affinity column, and
Autor:
Mayumi Morimoto, Nobuo N. Noda, Yoshinori Ohsumi, Kuninori Suzuki, Fuyuhiko Inagaki, Shingo Nakamura, Kiyonaga Fujii
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91651 (2014)
PLoS ONE
PLoS ONE
Macroautophagy (autophagy) is a bulk protein-degradation system ubiquitously conserved in eukaryotic cells. During autophagy, cytoplasmic components are enclosed in a membrane compartment, called an autophagosome. The autophagosome fuses with the vac
Autor:
Kiyonaga Fujii, Mitsutoshi Yoneyama, Fuyuhiko Inagaki, Masataka Horiuchi, Kiyohiro Takahasi, Nobuo N. Noda, Shingo Nakamura, Takashi Fujita
Publikováno v:
Genes to Cells.
The transcription factor IRF-3 is activated by microbial invasions and produces a variety of cytokines including type-I interferon. Upon microbial infection, IRF-3 is phosphorylated at its C-terminal regulatory domain, then oligomerized, translocated