Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Karel Souček"'
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved cancer therapy, the physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f1ccc011d8be1bda0430a0a7ec71ed
https://doi.org/10.1101/2021.06.29.450320
https://doi.org/10.1101/2021.06.29.450320
Autor:
Vondálová Blanářová O, Karel Souček, Michaela Nosková, Víchová R, Kristína Gömöryová, Gybel’ T, Zbynek Zdrahal, Karol Kaiser, Lucia Kucerova, Lucia Demkova, Bryja, David Potěšil, Katarzyna Anna Radaszkiewicz, Markéta Pícková, Tomasz Witold Radaszkiewicz
RNF43 is a E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopreci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::259dd6982413886159ca97f70622272a
https://doi.org/10.1101/2021.02.08.430210
https://doi.org/10.1101/2021.02.08.430210
Autor:
Ján Remšík, Aleš Hampl, Lucia Binó, Eva Slabáková, Karel Souček, Zuzana Kahounová, Daniela Kurfűrstová, Volodymyr Porokh, Radek Fedr, Vladimír Študent, Jan Bouchal, Radek Vrtěl, Lucie Jurečková
Publikováno v:
Stem Cell Research, Vol 33, Iss, Pp 255-259 (2018)
A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogramming Kit
Autor:
Lucie Jurečková, Veronika Pospíšilová, Petr Vaňhara, Aleš Hampl, Zuzana Holubcová, Vendula Pelková, Daniela Mináriková, Tomáš Bárta, Karel Souček, Dáša Bohačiaková, Volodymyr Porokh
Publikováno v:
Stem Cells and Development. 27:1077-1084
Chromosomal instability evoked by abnormalities in centrosome numbers has been traditionally considered as a hallmark of aberrant, typically cancerous or senescent cells. We have reported previously that pristine human embryonic stem cells (hESC) suf
Autor:
Zbyněk Zdráhal, Olga Vondálová Blanářová, Tomáš Gybeľ, Markéta Pícková, Lucia Kucerova, Ráchel Víchová, Kristína Gömöryová, Tomasz Witold Radaszkiewicz, Karol Kaiser, Vítězslav Bryja, David Potěšil, Tomáš Bárta, Michaela Nosková, Karel Souček, Lucia Demkova, Katarzyna Anna Radaszkiewicz
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopr
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplasti
Autor:
Zuzana Kahounová, Karel Souček, Jan Bouchal, Ján Remšík, Radek Fedr, Eva Slabáková, Lucia Binó, Alena Mickova, Aleš Hampl
Publikováno v:
Stem Cell Research, Vol 46, Iss, Pp 101844-(2020)
Deciphering the properties of adult stem cells is crucial for understanding of their role in healthy tissue and in cancer progression as well. Both stem cells and cancer stem cells have shown association with epithelial-to-mesenchymal transition (EMT
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that ep
Publikováno v:
Cytometry Part A. 93:239-248
Complex analysis of cellular responses after experimental treatment is important for screening, mechanistic understanding of treatment effects, and the identification of sensitive and resistant cell phenotypes. Modern multicolor flow cytometry has de
Autor:
Vladimír Študent, Zuzana Kahounová, Jan Bouchal, Alois Kozubík, Karel Souček, Gvantsa Kharaishvili, Ján Remšík, Daniela Kurfürstová, Šárka Šimečková, Jiří Navrátil
Publikováno v:
Cytometry Part A. 93:941-951
The identification of fibroblasts and cancer-associated fibroblasts from human cancer tissue using surface markers is difficult, especially because the markers used currently are usually not expressed solely by fibroblasts, and the identification of