Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jane A. Cox"'
Publikováno v:
Journal of Biological Chemistry. 294:12521-12533
Activation of ionotropic P2X receptors increases free intracellular Ca2+ ([Ca2+]i) by initiating a transmembrane cation flux. We studied the "a" and "k" splice variants of the rat purinergic P2X7 receptor (rP2X7aR and rP2X7kR) to exhibit a significan
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148726 (2016)
PLoS ONE
PLoS ONE
Peripheral glia are known to have a critical role in the initial response to axon damage and degeneration. However, little is known about the cellular responses of non-myelinating glia to nerve injury. In this study, we analyzed the transcriptomes of
Autor:
Anthony R. McAdow, Stephen L. Johnson, Jane A. Cox, Andrew S. McCallion, Amy E. Dinitz, Mark M. Voigt
Publikováno v:
Gene Expression Patterns. 11:409-414
The zebrafish is an ideal model for elucidating the cellular and molecular mechanisms that underlie development of the peripheral nervous system. A transgenic line that selectively labels all the sensory circuits would be a valuable tool for such inv
Publikováno v:
Current Topics in Medicinal Chemistry. 4:821-829
P2X receptors are ligand-gated ion channels that transduce many of the physiological effects of extracellular ATP. There has been a dramatic increase in awareness of these receptors over the past 5 or so years, in great part due to their molecular cl
Publikováno v:
Journal of Biological Chemistry. 276:32793-32798
Based on pharmacological properties, the P2X receptor family can be subdivided into those homo-oligomers that are sensitive to the ATP analog alphabeta-methylene ATP(alphabetameATP) (P2X(1) and P2X(3)) and those that are not (P2X(2), P2X(4), P2X(5),
Publikováno v:
Purinergic signalling. 5(3)
P2X receptors are non-selective cation channels operated by extracellular ATP. Currently, little is known concerning the functions of these receptors during development. Previous work from our lab has shown that zebrafish have two paralogs of the mam
Autor:
William R. Haines, Keisuke Migita, Mark M. Voigt, Jane A. Cox, Terrance M. Egan, Miguel Diaz-Hernandez
Publikováno v:
Biochemical and biophysical research communications. 295(4)
In this report we describe the cloning and characterization of two P2X receptor subunits cloned from the zebrafish (Danio rerio). Primary sequence analysis suggests that one cDNA encodes an ortholog of the mammalian P2X(4) subunit and the second cDNA
Publikováno v:
FEBS letters. 475(3)
We describe a P2X subunit cloned from the zebrafish (Danio rerio) that is an orthologue of the mammalian P2X(3) subunit. Like the mammalian P2X(3), this receptor desensitizes rapidly in the presence of agonist. However, it differs in that alphabeta-m
Autor:
Patrick Schloss, Christoph M. Schuster, Jane A. Cox, Heinrich Betz, Bertram Schmitt, Andreas Ultsch
Publikováno v:
Science (New York, N.Y.). 254(5028)
Insects and other invertebrates use glutamate as a neurotransmitter in the central nervous system and at the neuromuscular junction. A complementary DNA from Drosophila melanogaster, designated DGluR-II, has been isolated that encodes a distant homol
Publikováno v:
Developmental Biology. (2):305-317
The formation of branchiomeric nerves (cranial nerves V, VII, IX and X) from their sensory, motor and glial components is poorly understood. The current model for cranial nerve formation is based on the Vth nerve, in which sensory afferents are forme