Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Hiroyuki Inoue"'
Autor:
Junjiro Yoshida, Tomokazu Ohishi, Hikaru Abe, Shun-ichi Ohba, Hiroyuki Inoue, Ihomi Usami, Masahide Amemiya, Raphael Oriez, Chiharu Sakashita, Shingo Dan, Minoru Sugawara, Tokuichi Kawaguchi, Junko Ueno, Yuko Asano, Ami Ikeda, Manabu Takamatsu, Gulanbar Amori, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Tetsuo Noda, Takumi Watanabe, Takao Shimizu, Masakatsu Shibasaki, Manabu Kawada
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103497- (2021)
Summary: The disruption of the tumor microenvironment (TME) is a promising anti-cancer strategy, but its effective targeting for solid tumors remains unknown. Here, we investigated the anti-cancer activity of the mitochondrial complex I inhibitor int
Externí odkaz:
https://doaj.org/article/ff4620e0f1ac469da0b070bcc9c3a3bb
Autor:
Masako Seike, Shun-ichiro Asahara, Hiroyuki Inoue, Michiyo Kudo, Ayumi Kanno, Aisha Yokoi, Hirotaka Suzuki, Maki Kimura-Koyanagi, Yoshiaki Kido, Wataru Ogawa
Publikováno v:
Biochemical and Biophysical Research Communications. 652:121-130
Autor:
Tomoka Tabata, Yuki Masumura, Shuichiro Higo, Suzuka Kunimatsu, Satoshi Kameda, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Seiji Takashima, Mikio Watanabe, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata
Publikováno v:
Biochemical and Biophysical Research Communications. 637:40-49
Kinetic analysis of intracellular calcium (Ca
Autor:
Asuka Imai, Shun-ichiro Asahara, Chisako Hara, Yukina Kawada, Ayumi Kanno, Hiroyuki Inoue, Yoshiaki Kido, Maki Kimura-Koyanagi, Yumiko Sugiura
Publikováno v:
Biochemical and Biophysical Research Communications. 534:896-901
The reduction of pancreatic β cell mass is one of the key factors for the onset of type 2 diabetes. Many reports have indicated that insulin signaling is important for type 2 diabetes, but the mechanism by which insulin signaling is altered in pancr
Autor:
Manabu Kawada, Hiroyuki Inoue, Mirza S. Baig, Shun-ichi Ohba, Hikaru Abe, Tomokazu Ohishi, Takumi Watanabe, Uzma Saqib, Chiharu Sakashita, Masakatsu Shibasaki
Publikováno v:
International Journal of Cancer. 146:3474-3484
Modulation of prostate stromal cells (PrSCs) within tumor tissues is gaining attention for the treatment of solid tumors. Using our original in vitro coculture system, we previously reported that leucinostatin (LCS)-A, a peptide mycotoxin, inhibited
Autor:
Wataru Ofusa, Yoshiyuki Shibukawa, Hiroyuki Inoue, Sadao Oyama, Maki Kimura, Hidetaka Kuroda, Tatsuya Ichinohe
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5978, p 5978 (2021)
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5978, p 5978 (2021)
The ionotropic P2X receptor, P2X7, is believed to regulate and/or generate nociceptive pain, and pain in several neuropathological diseases. Although there is a known relationship between P2X7 receptor activity and pain sensing, its detailed function
Autor:
Yusuke Nakamichi, Hiroyuki Inoue, Thierry Fouquet, Akinori Matsushika, Masahiro Watanabe, Shotaro Ito
Publikováno v:
Journal of Biological Chemistry. 294:4065-4078
Glucuronoxylanases are endo-xylanases and members of the glycoside hydrolase family 30 subfamilies 7 (GH30-7) and 8 (GH30-8). Unlike for the well-studied GH30-8 enzymes, the structural and functional characteristics of GH30-7 enzymes remain poorly un
Autor:
Yasushi Sakata, Emiko Ito, Yasuaki Kohama, Yoshihiko Ikeda, Takumi Kondo, Tomoka Tabata, Shungo Hikoso, Mikio Shiba, Shigeru Miyagawa, Hiroyuki Inoue, Li Liu, Maki Takeda, Junjun Li, Seiji Takashima, Shuichiro Higo, Satoshi Kameda, Yoshiki Sawa, Satoki Nakamura
Publikováno v:
Human Molecular Genetics
Desmoglein-2, encoded by DSG2, is one of the desmosome proteins that maintain the structural integrity of tissues, including heart. Genetic mutations in DSG2 cause arrhythmogenic cardiomyopathy, mainly in an autosomal dominant manner. Here, we identi
Autor:
Seiji Takashima, Daisuke Okuzaki, Satoki Nakamura, Yasushi Sakata, Takamaru Ishizu, Satoshi Kameda, Shungo Hikoso, Tomoaki Higo, Yasuaki Kohama, Takumi Kondo, Tomoka Tabata, Shigeru Miyagawa, Mikio Shiba, Yuki Masumura, Hiroyuki Inoue, Yoshiki Sawa, Shuichiro Higo, Daisuke Motooka
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Post-mitotic cardiomyocytes have been considered to be non-permissive to precise targeted integration including homology-directed repair (HDR) after CRISPR/Cas9 genome editing. Here, we demonstrate that direct delivery of large amounts of transgene e
Autor:
Hiroyuki Nakayama, Hiroyuki Inoue, Yuta Takaichi, Akihiko Takashima, Kazuyuki Uchida, James K. Chambers, Yasuhisa Ano
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Neurodegenerative diseases are characterized by the accumulation of specific phosphorylated protein aggregates in the brain, such as hyperphosphorylated tau (hp-tau) in tauopathies and phosphorylated α-synuclein (p-αSyn) in α-synucleinopathies. Th