Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Hiroshi Sugiyama"'
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103455- (2021)
Summary: In cells, segregation allows for diverse biochemical reactions to take place simultaneously. Such intricate regulation of cellular processes is achieved through the dynamic formation and disassembly of membraneless organelles via liquid-liqu
Externí odkaz:
https://doaj.org/article/e647d2a2a64443a68a1563f69f792541
Autor:
Masamitsu Mikami, Tatsuya Masuda, Takuya Kanatani, Mina Noura, Katsutsugu Umeda, Hidefumi Hiramatsu, Hirohito Kubota, Tomoo Daifu, Atsushi Iwai, Etsuko Yamamoto Hattori, Kana Furuichi, Saho Takasaki, Sunao Tanaka, Yasuzumi Matsui, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Tatsutoshi Nakahata, Yasumichi Kuwahara, Tomoko Iehara, Hajime Hosoi, Yoichi Imai, Junko Takita, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
Publikováno v:
Molecules and Cells. 45:886-895
Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development of novel molecule-targeting therapeutic agents. In this study, we report the imp
Autor:
Yasuzumi Matsui, Yohei Mineharu, Yuki Noguchi, Etsuko Yamamoto Hattori, Hirohito Kubota, Masahiro Hirata, Susumu Miyamoto, Hiroshi Sugiyama, Yoshiki Arakawa, Yasuhiko Kamikubo
Publikováno v:
Biochemical and Biophysical Research Communications. 620:150-157
Malignancy of medulloblastoma depends on its molecular classification. Sonic Hedgehog (SHH)-type medulloblastoma with p53 mutation was recognized as one of the most aggressive types of tumors. We developed a novel drug, chlorambucil-conjugated PI-pol
Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model
Publikováno v:
Cell Chemical Biology. 29(3):463-475
Considering the potential of combinatorial therapies in overcoming existing limitations of cancer immunotherapy, there is an increasing need to identify small-molecule modulators of immune cells capable of augmenting the effect of programmed cell dea
Autor:
Yasuzumi Matsui, Yohei Mineharu, Yuki Noguchi, Etsuko Yamamoto Hattori, Hirohito Kubota, Masahiro Hirata, Susumu Miyamoto, Hiroshi Sugiyama, Yoshiki Arakawa, Yasuhiko Kamikubo
Publikováno v:
Biochemical and Biophysical Research Communications. 656:146-147
Autor:
Yumi Irie, Ikuo Tooyama, Jean-Pierre Bellier, Hiroyasu Akatsu, Yuka Matsushima, Yoshio Hashizume, Yusuke Kageyama, Daita Kaneda, Kunio Miki, Kazuhiro Irie, Hiroshi Sugiyama, Akiko Kita, Kumi Hidaka, Tatsuya Segawa, Douglas G. Walker
Publikováno v:
ACS Chemical Neuroscience. 12:3418-3432
Characterization of amyloid β (Aβ) oligomers, the transition species present prior to the formation of Aβ fibrils and that have cytotoxicity, has become one of the major topics in the investigations of Alzheimer's disease (AD) pathogenesis. Howeve
Autor:
Debojyoti De, Gengo Kashiwazaki, Ganesh N. Pandian, Nazia Parveen, Jieun An, Junichi Taniguchi, Tong Mook Kang, Hiroshi Sugiyama, Kyeong Kyu Kim, Jin-A Lee
Publikováno v:
Journal of Cellular Physiology. 236:3946-3962
The epigenome has an essential role in orchestrating transcriptional activation and modulating key developmental processes. Previously, we developed a library of pyrrole-imidazole polyamides (PIPs) conjugated with suberoylanilide hydroxamic acid (SAH
Autor:
Tomoko Emura, Akio Yamashita, Kumi Hidaka, Osamu Takeuchi, Noriki Iwai, Kentaro Inoue, Hiroshi Sugiyama, Kotaro Akaki, Fabian Hia, Takuya Uehata, Mariko Okada-Hatakeyama, Shigeo Ohno, Takashi Mino, Masayuki Endo, Yutaka Suzuki, Daron M. Standley
Publikováno v:
Nucleic Acids Research
Regnase-1-mediated mRNA decay (RMD), in which inflammatory mRNAs harboring specific stem–loop structures are degraded, is a critical part of proper immune homeostasis. Prior to initial translation, Regnase-1 associates with target stem–loops but
Publikováno v:
iScience
iScience, Vol 24, Iss 12, Pp 103455-(2021)
iScience, Vol 24, Iss 12, Pp 103455-(2021)
Summary In cells, segregation allows for diverse biochemical reactions to take place simultaneously. Such intricate regulation of cellular processes is achieved through the dynamic formation and disassembly of membraneless organelles via liquid-liqui
Autor:
Toshikazu Bando, Hiroshi Sugiyama, Satoru Ide, Asuka Sasaki, Yusuke Kawamoto, Kazuhiro Maeshima
Publikováno v:
Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-16 (2021)
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-16 (2021)
Background Knowing chromatin components at a DNA regulatory element at any given time is essential for understanding how the element works during cellular proliferation, differentiation and development. A region-specific chromatin purification is an