Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Hiroaki Konishi"'
Autor:
Tasuku Nishino, Takaya Abe, Mari Kaneko, Masanao Yokohira, Keiko Yamakawa, Katsumi Imaida, Hiroaki Konishi
Publikováno v:
Biochemical and Biophysical Research Communications. 628:91-97
The adaptor protein GAREM has two subtypes. Each is involved in Erk activation signaling downstream of the cell growth factor receptor in cultured cells. Regarding their role in individual animals, we have previously reported that mice deficient in G
Autor:
Alex Q. Lee, Hiroaki Konishi, Elizabeth Helmke, Masami Ijiri, Jan Michael A. Lerot, Emma Hicks, Jeremy R. Chien, Fredric A. Gorin, Noriko Satake
Publikováno v:
Experimental Hematology. :8-13.e1
B-cell acute lymphoblastic leukemia (B-ALL) is the most common type of cancer found in children. Although the overall survival rates are now >80%, 15%-20% of pediatric patients relapse, with survival rates subsequently dropping to 5%-10%. Cmpd10357,
Publikováno v:
Cellular & Molecular Biology Letters, Vol 26, Iss 1, Pp 1-11 (2021)
Cellular & Molecular Biology Letters
Cellular & Molecular Biology Letters
Background In mammals, there are two subtypes of Grb2-associated regulator of Erk/MAPK (GAREM), an adaptor protein that functions downstream of the cell growth factor receptor. GAREM1 is ubiquitously expressed, whereas GAREM2 is mainly expressed in t
Autor:
Takuya Iwama, Katsuyoshi Ando, Hiroaki Konishi, Tatsuya Dokoshi, Shin Kashima, Aki Sakatani, Hiroki Tanaka, Mikihiro Fujiya, Nobuhiro Ueno, Toshikatsu Okumura, Kentaro Moriichi
Publikováno v:
Cell Death and Disease, Vol 11, Iss 4, Pp 1-16 (2020)
Cell Death & Disease
Cell Death & Disease
RNA regulation mediating RNA-binding proteins (RBPs) have been shown to be related to the maintenance of homeostasis as well as cancer progression. However, the tumor-associated functions as well as the detailed mechanisms underlying the anti-tumor e
Autor:
Shuhei Takauji, Hiroki Tanaka, Shotaro Isozaki, Kie Horioka, Hiroaki Konishi, Mineji Hayakawa
Publikováno v:
Biochemical and biophysical research communications. 587
Background Accidental hypothermia (AH) sometimes leads to coagulation disorder, especially in severe AH. We previously demonstrated that intrasplenic platelet activation caused aberrant hemostasis and thrombus formation after rewarming in a murine AH
Autor:
Katsuyoshi Ando, Shin Kashima, Shotaro Isozaki, Yuki Murakami, Toshikatsu Okumura, Kentaro Moriichi, Nobuhiro Ueno, Hiroaki Konishi, Hiroki Tanaka, Mikihiro Fujiya
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), is an intractable intestinal inflammation associated with the disruption of the intestinal mucosa. We previously demonstrated that Lactobacillus brevis-deri
Autor:
Ryota Matsunaga, Hiroaki Konishi, Hiroshi Kiyonari, Fumio Shimamoto, Hiroshi Jikihara, Tasuku Nishino, Satoshi Tashiro, Guangying Qi, Takaya Abe, Moe Uchida, Kyoko Inagaki-Ohara, Akane Maeda
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861:1816-1827
Cardiolipin and phosphatidic acid-binding protein (CLPABP) is a pleckstrin homology domain-containing protein and is localized on the surface of mitochondria of cultured cells as a large protein–RNA complex. To analyze the physiological functions o
Autor:
Atsushi Yokoyama, Tasuku Nishino, Hiroaki Konishi, Toshiki Yagi, Hiroshi Suga, Ryota Matsunaga, Akane Maeda
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1866(2)
WDR54 is a member of the WD40 repeat (WDR) domain-containing protein family that was recently identified as a novel oncogene in colorectal cancer. However, the molecular mechanism of WDR54 and its functional association with other molecules related t
Autor:
Katsuya Ikuta, Kentaro Moriichi, Nobuhiro Ueno, Yutaka Kohgo, Hiroki Tanaka, Hiroaki Akutsu, Mikihiro Fujiya, Hiroaki Konishi, Junpei Sasajima, Hiroki Tanabe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications
Previous reports have suggested that some probiotics inhibit tumorigenesis and cancer progression. However, the molecules involved have not yet been identified. Here, we show that the culture supernatant of Lactobacillus casei ATCC334 has a strong tu
Autor:
Yutaka Kohgo, Hiroki Tanabe, Nobuhiro Ueno, Junpei Sasajima, Kentaro Moriichi, Hiroki Tanaka, Katsuya Ikuta, Mikihiro Fujiya, Hiroaki Konishi
Publikováno v:
Biochemical and Biophysical Research Communications. 467:847-852
While the progress of chemotherapy and molecular targeted therapy has improved the outcome of colorectal cancer patients, the mortality of colon cancer remains high, indicating the need to develop novel therapeutic targets for improving the outcome o