Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Runliu Wu, Daniel J. Klionsky, Daolin Tang, Xin Chen, Jingbo Li, Xinxin Song, Herbert J. Zeh, Yinghua Xu, Xiaoyan Wang, Rui Kang, Jiao Liu
Publikováno v:
Autophagy
Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation process that plays a complex role in cellular stress, either promoting survival or triggering death. Early studies suggest that ferroptosis, an iron-dependen
Publikováno v:
Autophagy
Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter “autophagy”) is one of the lysosome-dependent degradation systems that
Autor:
Guido Kroemer, Yangchun Xie, Leng Han, Herbert J. Zeh, Enyong Dai, Jiao Liu, Rui Kang, Daniel J. Klionsky, Jing Wang, Daolin Tang
Publikováno v:
Autophagy
KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we rep
Autor:
Herbert J. Zeh, Ulka Sachdev, Sebastian Vogel, Xiangdong Cui, Pranav Murthy, Michael T. Lotze
Publikováno v:
Biochemical and Biophysical Research Communications. 508:614-619
Platelets play a critical role in the pathophysiology of peripheral arterial disease (PAD). The mechanisms by which muscle ischemia regulates aggregation of platelets are poorly understood. We have recently identified the Nod-like receptor nucleotide
Publikováno v:
Biochemical and Biophysical Research Communications. 506:278-283
Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme derived from Streptococcus that has been widely used for genome editing in a variety of organisms, including humans. Here, we report that exogenous Cas9 protein can elicit an
Autor:
Xinxin Song, Xin Chen, Feimei Kuang, Daolin Tang, Herbert J. Zeh, Jiao Liu, Rui Kang, Guido Kroemer, Yangchun Xie
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108767-(2021)
Cell Reports
Cell Reports, Elsevier Inc, 2021, 34 (8), pp.108767. ⟨10.1016/j.celrep.2021.108767⟩
Cell Reports, 2021, 34 (8), pp.108767. ⟨10.1016/j.celrep.2021.108767⟩
Cell Reports
Cell Reports, Elsevier Inc, 2021, 34 (8), pp.108767. ⟨10.1016/j.celrep.2021.108767⟩
Cell Reports, 2021, 34 (8), pp.108767. ⟨10.1016/j.celrep.2021.108767⟩
International audience; Although induction of ferroptosis, an iron-dependent form of non-apoptotic cell death, has emerged as an anticancer strategy, the metabolic basis of ferroptotic death remains poorly elucidated. Here, we show that glucose deter
Autor:
Daolin Tang, Ling Zeng, Daniel J. Klionsky, Borong Zhou, Shan Zhu, Jianxin Jiang, Timothy R. Billiar, Guido Kroemer, Haichao Wang, Jiao Liu, Herbert J. Zeh, Rui Kang
Publikováno v:
Autophagy
Sepsis is the most common cause of death for patients in intensive care worldwide due to a dysregulated host response to infection. Here, we investigate the role of sequestosome-1 (SQSTM1/p62), an autophagy receptor that functions as a regulator of i
Publikováno v:
Autophagy. 14:2173-2175
Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system X(c)(−). However, key regulators of system X(c)(−) activity in ferroptosis remain undefined. Here, we show t
Autor:
Qiuhong Zhang, Shan Zhu, Michael T. Lotze, Xiaofang Sun, Rui Kang, Daolin Tang, Herbert J. Zeh
Publikováno v:
Cancer Research. 77:2064-2077
Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid peroxidation, although detailed molecular regulators are largely unknown. Here, we show that heatshock 70-kDa protein 5 (HSPA5) negatively regulates ferroptosis
Autor:
Michael T. Lotze, Shan Zhu, Daniel J. Klionsky, Herbert J. Zeh, Minghua Yang, Jiao Liu, Rui Kang, Guido Kroemer, Daolin Tang, Pan Chen
Publikováno v:
Science Advances
Autophagy
Autophagy
Autophagy-dependent cell death may hold the key to understanding the molecular basis of ferroptosis.
Ferroptosis is a form of nonapoptotic regulated cell death driven by iron-dependent lipid peroxidation. Autophagy involves a lysosomal degradati
Ferroptosis is a form of nonapoptotic regulated cell death driven by iron-dependent lipid peroxidation. Autophagy involves a lysosomal degradati