Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Guangxun Meng"'
Publikováno v:
Science Bulletin. 66:2115-2123
Inflammasomes and their product interleukin 18 (IL-18) play important roles in gut microbiota monitoring and homeostasis, and their loss of function could lead to microbiota dysbiosis and accelerate disease progression. However, the impacts of the re
Autor:
Yangyang Zhu, Hao Zhang, Huawei Mao, Suqin Zhong, Yubing Huang, Sirong Chen, Kai Yan, Zhibin Zhao, Xiaohan Hao, Yue Zhang, Han Yao, Xiaowan Huang, Meimei Wang, Wenbin Zhang, Juan Li, Guangxun Meng, Xiaohua Qin, Zhiming Ye, Jiani Shen, Yang Song, Youcui Xu, Zhenyu Yang, Liansheng Wang, Yunjiao Zhang, Longping Wen
Publikováno v:
Cell death and differentiation.
NLRP3, the sensor protein of the NLRP3 inflammasome, plays central roles in innate immunity. Over-activation of NLRP3 inflammasome contributes to the pathogenesis of a variety of inflammatory diseases, while gain-of-function mutations of NLRP3 cause
Autor:
Hervé Lecoeur, Thibault Rosazza, Kossiwa Kokou, Hugo Varet, Jean-Yves Coppée, Arezou Lari, Pierre-Henri Commère, Robert Weil, Guangxun Meng, Genevieve Milon, Gerald F. Späth, Eric Prina
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2020, 1, ⟨10.3389/fimmu.2020.01098⟩
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, 2020, 1, ⟨10.3389/fimmu.2020.01098⟩
Frontiers in Immunology, Frontiers, 2020, 1, ⟨10.3389/fimmu.2020.01098⟩
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, 2020, 1, ⟨10.3389/fimmu.2020.01098⟩
International audience; Leishmania parasites are the causative agents of human leishmaniases. They infect professional phagocytes of their mammalian hosts, including dendritic cells (DCs) that are essential for the initiation of adaptive immune respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab7917497f65456ff21c9debd0933f0
https://hal-pasteur.archives-ouvertes.fr/pasteur-02861456/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-02861456/document
Autor:
Cuiping Zhang, Changzhou Shao, Rujia Tao, Xiaoyan Chen, Xiao Su, Caiqi Zhao, Xing Liu, Guangxun Meng, Sijiao Wang
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 6, Pp 1-13 (2020)
Cell Death and Disease, Vol 11, Iss 6, Pp 1-13 (2020)
Mesenchymal stem cells (MSCs) have been used in cell-based therapies for a variety of disorders. Some factors such as inflammatory mediators in the diseased area might damage the survival of MSCs and affect their efficacy. Pyroptosis is a form of pro
Autor:
Paya N’Diaye, Guangxun Meng, Nathalie Aulner, Eric Prina, Hugo Varet, Kossiwa Kokou, Robert Weil, Yue Xing, Thibault Rosazza, Gerald F. Späth, Geneviève Milon, Giovanni Bussotti, Hervé Lecoeur
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2020, 30 (6), pp.1870-1882.e4. ⟨10.1016/j.celrep.2020.01.030⟩
Cell Reports, Vol 30, Iss 6, Pp 1870-1882.e4 (2020)
Cell Reports, 2020, 30 (6), pp.1870-1882.e4. ⟨10.1016/j.celrep.2020.01.030⟩
Cell Reports, Elsevier Inc, 2020, 30 (6), pp.1870-1882.e4. ⟨10.1016/j.celrep.2020.01.030⟩
Cell Reports, Vol 30, Iss 6, Pp 1870-1882.e4 (2020)
Cell Reports, 2020, 30 (6), pp.1870-1882.e4. ⟨10.1016/j.celrep.2020.01.030⟩
Summary: Aberrant macrophage activation during intracellular infection generates immunopathologies that can cause severe human morbidity. A better understanding of immune subversion strategies and macrophage phenotypic and functional responses is nec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b44a886f36effc3b7a196c24f53474
https://hal-pasteur.archives-ouvertes.fr/pasteur-02562442/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-02562442/document
Autor:
Lih-Wen Deng, Peipei Zhou, Lulu Liu, Xiaodan Ding, Guangxun Meng, Xinhui Hui, Bin Li, Fajian Hou, Xiujie Yuan, Jin Zhong, Hui Xiao, Xiaoling Wan, Wei Zhang, Yan Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Trithorax group protein MLL5 is an important epigenetic modifier that controls cell cycle progression, chromatin architecture maintenance, and hematopoiesis. However, whether MLL5 has a role in innate antiviral immunity is largely unknown. Here we sh
Autor:
Jiajun Fan, Dianwen Ju, Wei Chen, Yichen Wang, Yanxu Liang, Yanyang Nan, Jingyun Luan, Xuyao Zhang, Guangxun Meng
Publikováno v:
Nanoscale. 10:9141-9152
Increased biomedical applications of mesoporous silica nanoparticles (MSNs) raise considerable attention concerning their toxicological effects; the toxicities of MSNs are still undefined and the underlying mechanisms are unknown. We conducted this s
Autor:
Qiuhong Guo, Guiwen Yang, Guangxun Meng, Guang Xue, Xiaomin Yao, Liguo An, Yue Xing, Hua Li, Yan Zhang
Publikováno v:
The Journal of Immunology. 199:1561-1566
NLRP3 inflammasome activiation requires two sequential signals. The priming signal 1 from TLRs or cytokine receptors induces the transcription of NLRP3 and IL-1β, and concomitantly promotes transcription-independent activation of caspase-1. The acti
Autor:
Rongbin Zhou, Qiyao Chai, Yoichiro Iwakura, Feng Tian, Lihua Qiang, George F. Gao, Guangxun Meng, Jing Wang, Dongdong Zhao, Mingzhao Zhu, Cui Hua Liu, Pupu Ge
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Mycobacterium tuberculosis PtpA is a secreted effector protein that dephosphorylates several proteins in the host cell cytoplasm, such as p-JNK, p-p38, and p-VPS33B, leading to suppression of host innate immunity. Here we show that, in addition, PtpA
Autor:
Qun Xie, Guizhen Wang, Guangxun Meng, Zhen-Zong Fa, Chao Zhang, Jiu Yi, Wanqing Liao, Wei Fang, Julin Gu
Publikováno v:
CNS Neuroscience & Therapeutics. 23:291-300
SummaryIntroduction Fungal transversal across the brain microvascular endothelial cells (BMECs) is the essential step for the development of cryptococcal meningoencephalitis. Annexin A2 (AnxA2) is an important signaling protein involved in several in