Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Geethu E. Thomas"'
Autor:
Dilshad H. Khan, Veronique Voisin, Jonathan St-Germain, Andrea Arruda, Geethu E. Thomas, Changjiang Xu, Rose Hurren, Elias Orouji, Mark D. Minden, Boaz Nachmias, Neil MacLean, Brian Raught, Ayesh K. Seneviratne, Gary D. Bader, Xiaoming Wang, Liran I. Shlush, Aaron D. Schimmer, Aaron Botham
Publikováno v:
Blood. 136:22-23
While most patients with acute myeloid leukemia (AML) achieve remission with initial therapy, the majority relapse leading to poor overall survival. Relapse is frequently driven by a rare subset of leukemic stem cells (LSC). Understanding biological
Autor:
Neil MacLean, Elias Orouji, Kerstin B. Kaufmann, Rose Hurren, Mark D. Minden, Aaron Botham, Veronique Voisin, Grace Egan, Geethu E. Thomas, Boaz Nachmias, Rashim Pal Singh, John E. Dick, Marcela Gronda, Jordan Chin, Dilshad H. Khan, Gary D. Bader, Laura Gracia Prat, Aaron D. Schimmer, Andrea Arruda, Xiaoming Wang
Publikováno v:
Cancer Research. 81:3099-3099
Mitochondrial metabolites affect epigenetic marks, but it is largely unknown whether mitochondrial metabolic enzymes can directly localize to the nucleus to regulate stem cell function in AML. Here, we discovered that the mitochondrial enzyme, Hexoki
Autor:
Mathieu Lupien, Yulia Jitkova, Michael Mullokandov, Helen Loo Yau, Rima Al-awar, James R. Hawley, Rose Hurren, Troy Ketela, S. Kim, Veronique Voisin, Neil MacLean, Daniel D. De Carvalho, Mark D. Minden, Geethu E. Thomas, Val A. Fajardo, Ahmed Aman, Zhenyue Hao, Zaza Khuchua, G. Wei Xu, Gary D. Bader, Richard P. Bazinet, Juan J. Aristizabal Henao, Mingjing Xu, Paul J. LeBlanc, Ayesh K. Seneviratne, Steven M. Claypool, Steven M. Chan, Xiaoming Wang, Atan Gross, Aaron D. Schimmer, Ken D. Stark, David Sharon, Raphaël Chouinard-Watkins, Danny V. Jeyaraju, Caitlin Schafer, Marcela Gronda
Summary Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b74e60e809d7c98db8697836fef410
https://europepmc.org/articles/PMC7137093/
https://europepmc.org/articles/PMC7137093/
Autor:
Rose Hurren, Razq Hakem, Parasvi S. Patel, Neil MacLean, Grace Egan, Aaron D. Schimmer, Geethu E. Thomas
Publikováno v:
Blood. 136:2-2
While most patients with AML achieve remission with standard induction chemotherapy, the majority ultimately relapse. Relapsed AML is due, at least in part, to the persistence of chemoresistant leukemia stem cells (LSCs). The mechanisms of chemoresis
Autor:
Aaron D. Schimmer, Jordan Chin, Razq Hakem, Grace Egan, Aaron Botham, Parasvi S. Patel, Geethu E. Thomas, Rose Hurren, Neil MacLean
Publikováno v:
Cancer Research. 80:3784-3784
Leukemia stem cells are responsible for the initiation and recurrence of AML. Cell differentiation requires the coordination of metabolic state and gene expression programs. It is known that metabolic intermediates can serve as cofactors in epigeneti
Autor:
Mark D. Minden, Neil MacLean, Steven M. Chan, Sanduni Liyanagae, Sara Mirali, Changjiang Xu, James R. Hawley, Samir H. Barghout, Rashim Pal Singh, Elias Orouji, Aaron D. Schimmer, Xiaoming Wang, Gary D. Bader, Marcela Gronda, Dilshad H. Khan, Joelle Soriano, Mathieu Lupien, Veronique Voisin, Yulia Jitkova, Danny V. Jeyaraju, Geethu E. Thomas, David Sharon, Adina Borenstein, Rose Hurren, Ayesh K. Seneviratene, Andrea Arruda
Publikováno v:
Cell Stem Cell. 26:926-937.e10
Leukemic stem cells (LSCs) rely on oxidative metabolism and are differentially sensitive to targeting mitochondrial pathways, which spares normal hematopoietic cells. A subset of mitochondrial proteins is folded in the intermembrane space via the mit
Autor:
Geethu E. Thomas, Rose Hurren, John E. Dick, Laura Garcia Prat, Neil MacLean, Xiaoming Wang, Botham Aaron, Marcela Gronda, Aaron D. Schimmer
Publikováno v:
Blood. 132:2795-2795
Hematopoietic cells are arranged in a hierarchy where stem and progenitor cells differentiate into mature blood cells. Likewise, AML (Acute Myeloid Leukemia) is also hierarchical with leukemic stem and progenitor cells giving rise to more mature and
Autor:
Zachary Blatman, Rose Hurren, Aaron D. Schimmer, Geethu E. Thomas, Samir H. Barghout, Neil MacLean, G. Wei Xu
Publikováno v:
Blood. 132:1350-1350
UBA1 is the major ubiquitin-activating enzyme that initiates the ubiquitylation cascade whereby proteins are tagged with mono- or polyubiquitin to mark them for proteasomal degradation or modify their functions. Despite having equal levels of UBA1 pr