Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel T. Meehan"'
Autor:
Brianna Dufek, Edward Doyle, Michael Anne Gratton, Ross Coenen, Daniel T. Meehan, Brendan J Smyth, Jacob Madison, Gina Samuelson, Kevin Wilhelm, Dominic Cosgrove, Grady Phillips, Duane Delimont
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237907 (2020)
PLoS ONE
PLoS ONE
Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels of extracel
Autor:
Shiguang Liu, Duane Delimont, Brianna Dufek, Michael Anne Gratton, Linda Cheung, Wenping Song, Grady Phillips, Daniel T. Meehan, Dominic Cosgrove
Publikováno v:
Kidney International. 90:300-310
Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the subcapillar
Autor:
Gina Samuelson, Duane Delimont, Michael Anne Gratton, Flint A Boettcher, Daniel T. Meehan, Xiourui Shi, Jacob Madison, Brianna Dufek, Dominic Cosgrove, Vincent Trosky
Publikováno v:
Hear Res
In 129 Sv autosomal Alport mice, the strial capillary basement membranes (SCBMs) progressively thicken between 5 and 9 weeks of age resulting in a hypoxic microenvironment with metabolic stress and induction of pro-inflammatory cytokines and chemokin
Autor:
Duane Delimont, Grady Phillips, Daniel T. Meehan, Dominic Cosgrove, Brianna Dufek, Marisa Zallocchi, Michael Anne Gratton
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99083 (2014)
PLoS ONE
PLoS ONE
It has been known for some time that laminins containing α1 and α2 chains, which are normally restricted to the mesangial matrix, accumulate in the glomerular basement membranes (GBM) of Alport mice, dogs, and humans. We show that laminins containi
Autor:
Dominic Cosgrove, Raghu Kalluri, Aldo Amatucci, Phillip Gotwals, Daniel T. Meehan, Victor E. Kotelianski, Humphrey Gardner, Karen Bovard, Amy Gilroy, Caroline Miller, Kathryn D. Rodgers
Publikováno v:
Scopus-Elsevier
Alport syndrome is a genetic disorder resulting from mutations in type IV collagen genes. The defect results in pathological changes in kidney glomerular and inner-ear basement membranes. In the kidney, progressive glomerulonephritis culminates in tu
Autor:
Michael Anne Gratton, Joseph Rutledge, Duane Delimont, Marisa Zallocchi, Dominic Cosgrove, Daniel T. Meehan, John G. Flannery
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30573 (2012)
PLoS ONE
PLoS ONE
The molecular mechanisms underlying hair cell synaptic maturation are not well understood. Cadherin-23 (CDH23), protocadherin-15 (PCDH15) and the very large G-protein coupled receptor 1 (VLGR1) have been implicated in the development of cochlear hair
Autor:
Michael Anne Gratton, Christie A. Rothermund-Franklin, Charles Askew, Suneetha Garige, Daniel T. Meehan, Duane Delimont, Marisa Zallocchi, Dominic Cosgrove
Publikováno v:
Hearing research. 255(1-2)
The Usher syndrome 3A (CLRN1) gene encodes clarin-1, which is a member of the tetraspanin family of transmembrane proteins. Although identified more than 6 years ago, little is known about its localization or function in the eye and ear. We developed
Autor:
Norman L. Hawes, Dominic Cosgrove, Duane Delimont, Daniel T. Meehan, You Wei Peng, Bo Chang, Weimin Wang, Marisa Zallocchi
Publikováno v:
Investigative ophthalmologyvisual science. 49(10)
Purpose The role of integrin/cell matrix interactions between the RPE and the basement membrane in retinal maintenance and function is not well characterized. In this study the functional importance of alpha1beta1 integrin for retinal pigment epithel
Publikováno v:
Hearing research. 163(1-2)
The interaction of extracellular matrix and receptors plays a role in tissue homeostasis. The thickened strial capillary basement membrane (SCBM) reported in animal models of presbycusis and Alport's syndrome might be secondary to elevated synthesis
Autor:
Velidi H. Rao, Daniel T. Meehan, Kathyrn D. Rodgers, Xiwu Chen, Duane Delimont, Ambra Pozzi, Dominic Cosgrove
Publikováno v:
Matrix Biology. 25:S61-S61