Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Christian Sell"'
Publikováno v:
GeroScience. 44:683-698
Persistent DNA damage (genotoxic stress) triggers signaling cascades that drive cells into apoptosis or senescence to avoid replicating a damaged genome. Sp1 has been found to play a role in double strand break (DSB) repair, and a link between Sp1 an
Publikováno v:
Cell Cycle
A key to longevity assurance is the nutrient-sensing mTOR pathway. Inhibition of mTOR extends lifespan in a variety of organisms. However, the downstream effectors of the mTOR pathway for lifespan regulation are elusive. In a recent report, we descri
Autor:
Timothy Nacarelli, Ashley Azar, Manali Potnis, Gregg Johannes, Joshua Mell, F. Brad Johnson, Holly Brown-Borg, Eishi Noguchi, Christian Sell
Publikováno v:
Molecular biology of the cell. 33(5)
Cellular senescence is a terminal cell fate characterized by growth arrest and a metabolically active state characterized by high glycolytic activity. Human fibroblasts were placed in a unique metabolic state using a combination of methionine restric
Autor:
Veronica Cocchi, Amany Attaallah, Monia Lenzi, Silvana Hrelia, Antonello Lorenzini, Silvia Marchionni, Eleonora Croco, Christian Sell, Patrizia Hrelia, Giacomo Bincoletto
Publikováno v:
GeroScience
Cellular senescence is a fundamental process that may play positive or detrimental roles for the organism. It is involved in tissue development and in tumor prevention although during aging is becoming a detrimental process contributing to the declin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e1746b79fb9cfdb53804d47b68dc93
http://hdl.handle.net/11585/763575
http://hdl.handle.net/11585/763575
Autor:
Antonello Lorenzini, Christian Sell
Publikováno v:
Aging (Albany NY)
Cellular senescence is a biological phenomenon that has received many interpretations since its original description by Hayflick and Moorhead in 1961. A hypothesis proposed over 40 years ago is now generally accepted: i.e. that cellular senescence is
Autor:
Eishi Noguchi, Joshua Chang Mell, Sydney Wilson, Esteban Martínez, Christian Sell, Mihir Shetty, Kazuhiro Shiozaki, Chiaki Noguchi
Publikováno v:
Aging cell, vol 19, iss 2
Aging Cell
Aging Cell
Maf1 is the master repressor of RNA polymerase III responsible for transcription of tRNAs and 5S rRNAs. Maf1 is negatively regulated via phosphorylation by the mTOR pathway, which governs protein synthesis, growth control, and lifespan regulation in
Publikováno v:
GeroScience. 40:243-256
Inhibition of mTOR signaling using rapamycin has been shown to increase lifespan and healthspan in multiple model organisms; however, the precise mechanisms for the beneficial effects of rapamycin remain uncertain. We have previously reported that ra
Autor:
Claudio Torres, Michael Bene, Christian Sell, Ashley Azar, Timothy Nacarelli, Gregg J. Johannes, Ibiyonu Lawrence, Justin Cohen
Publikováno v:
GeroScience. 40:193-199
Cellular senescence is a central component of the aging process. This cellular response has been found to be induced by multiple forms of molecular damage and senescent cells increase in number with age in all tissues examined to date. We have examin
Publikováno v:
Annals of the New York Academy of Sciences. 1418:95-105
Both methionine restriction and rapamycin treatment are robust longevity-enhancing regimens for which the mechanisms remain unclear. Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin r
Autor:
Christian Sell, Timothy Nacarelli
Publikováno v:
Molecular and Cellular Endocrinology. 455:83-92
Cellular senescence has gained much attention as a contributor to aging and susceptibility to disease. Senescent cells undergo a stable cell cycle arrest and produce pro-inflammatory cytokines. However, an additional feature of the senescence phenoty