Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Anna Mae Diehl"'
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104955- (2022)
Summary: The immense regenerative potential of the liver is attributed to the ability of its two key cell types – hepatocytes and cholangiocytes – to trans-differentiate to one another either directly or through intermediate progenitor states. Ho
Externí odkaz:
https://doaj.org/article/62d9bb7073324bedb4c4534f669b8db3
Autor:
Christopher C. Pan, Raquel Maeso-Díaz, Tylor R. Lewis, Kun Xiang, Lianmei Tan, Yaosi Liang, Liuyang Wang, Fengrui Yang, Tao Yin, Calvin Wang, Kuo Du, De Huang, Seh Hoon Oh, Ergang Wang, Bryan Jian Wei Lim, Mengyang Chong, Peter B. Alexander, Xuebiao Yao, Vadim Y. Arshavsky, Qi-Jing Li, Anna Mae Diehl, Xiao-Fan Wang
Publikováno v:
Cell Research.
Autor:
Raquel Maeso‐Díaz, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, Anna Mae Diehl
Publikováno v:
Aging Cell. 21
Older age is a major risk factor for damage to many tissues, including liver. Aging undermines resiliency and impairs liver regeneration. The mechanisms whereby aging reduces resiliency are poorly understood. Hedgehog is a signaling pathway with crit
Autor:
Valentin Gogonea, George D. Dalton, Amanda L. Brown, Anna Mae Diehl, Seh-Hoon Oh, Stephanie Zhang, Preeti Pathak, Camelia Baleanu-Gogonea, Linda Tang, Venkateshwari Varadharajan, J. Mark Brown
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103089-(2021)
Summary: Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sens
Liver is one of the few organs with immense regenerative potential even at adulthood in mammals. It is composed of primarily two cell types: hepatocytes and cholangiocytes, that can trans-differentiate to one another either directly or through interm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5749d0f1b1ec3c7f7913f7df6e5b49
https://doi.org/10.1101/2021.04.22.440352
https://doi.org/10.1101/2021.04.22.440352
Publikováno v:
Nature Metabolism. 1:1027-1029
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease worldwide, mainly because of the massive parallel global increase in obesity. Extensive public-health and political efforts will be needed in the near future to
Autor:
Michael Wagner, Justin P. Wright, Sharon Jiang, Thomas M. O’Connell, Lawrence A. David, Fátima C. Pereira, Anna Mae Diehl, Richard T. Premont, Tyler R. Kartzinel, David Berry, Anchi Wu, Arno Schintlmeister, Robert M. Pringle, Heather K. Durand, Robert R. Dunn, Xiyou Zhou, Aspen T. Reese, Susan C. Alberts, Laura P. Hale
Publikováno v:
Nature Microbiology
Nature microbiology
Nature microbiology
Resource limitation is a fundamental factor governing the composition and function of ecological communities. However, the role of resource supply in structuring the intestinal microbiome has not been established and represents a challenge for mammal
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 22 (2020)
JCI Insight, Vol 5, Iss 22 (2020)
Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its mass while sustaining essential metabolic functions. How the liver balances dual demands for increased proliferative activity with maintenance of organ f
Autor:
Jason Gibson, David S. Hsu, Jeongeun Hyun, Anna Mae Diehl, Simon G. Gregory, Richard T. Premont, Cynthia D. Guy, Mark L. Jewell, Kuo Du, Seh-Hoon Oh, Thomas J. Ribar
Publikováno v:
Am J Pathol
Fibrolamellar carcinoma (FLC) is characterized by in-frame fusion of DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1) with protein kinase cAMP-activated catalytic subunit α (PRKACA) and by dense desmoplasia. Surgery is the only effective tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7b8fb52946e0d6a93a78c380043659
https://europepmc.org/articles/PMC10069284/
https://europepmc.org/articles/PMC10069284/
Autor:
Jeongeun Hyun, Anna Mae Diehl, Matthew B Friedersdorf, Youngmi Jung, Seh-Hoon Oh, Jack D. Keene, Richard T. Premont, Ji Eun Kim, Sihyung Wang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 3, Pp 1215-1229 (2018)
Background/Aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis. Because many factors interact to regulate expansion and regression of MF-HSC populations, eff