Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Kensuke Suzuki, Yasunori Masuike, Rei Mizuno, Uma M. Sachdeva, Priya Chatterji, Sarah F. Andres, Wenping Sun, Andres J. Klein-Szanto, Sepideh Besharati, Helen E. Remotti, Michael P. Verzi, Anil K. Rustgi
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status that is preserved even in metastatic tumors. However, the molecular mechanisms underlying CRC differentiation remain to be elucidated. Herein, we unravel a
Externí odkaz:
https://doaj.org/article/83ff55ab14b94dd0b2d998b9172249d6
Autor:
Priya Chatterji, Uma M. Sachdeva, Helen Remotti, Rei Mizuno, Kensuke Suzuki, Anil K. Rustgi, Michael P. Verzi, Sepideh Besharati, Yasunori Masuike, Wenping Sun, Sarah F. Andres, Andres J. Klein-Szanto
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status that is preserved even in metastatic tumors. However, the molecular mechanisms underlying CRC differentiation remain to be elucidated. Herein, we unravel a
Autor:
Joel Gabre, Jianwen Que, Angela J. Yoon, Ricardo Cruz-Acuna, Gary W. Falk, Shoji Natsugoe, Adam J. Bass, Julian A. Abrams, Tatiana A. Karakasheva, Lorenzo Ferri, Veena Sangwan, Anil K. Rustgi, Timothy C. Wang, Hiroshi Nakagawa, Varun Sahu, Kelly A. Whelan, Gregory G. Ginsberg, Elizabeth Philipone, J. Alan Diehl, Veronique Giroux, Hisatsugu Maekawa, Andres J. Klein-Szanto, Devraj Basu, Masataka Shimonosono, Takashi Kijima
Publikováno v:
Curr Protoc Stem Cell Biol
Esophageal cancers comprise adenocarcinoma and squamous cell carcinoma, two distinct histologic subtypes. Both are difficult to treat and among the deadliest human malignancies. We describe protocols to initiate, grow, passage, and characterize patie
Autor:
Priya Chatterji, Veronique Giroux, E. Paul Wileyto, Anil K. Rustgi, Kathryn E. Hamilton, Ben Rhoades, Christopher J. Lengner, Julien Stephan, Andres J. Klein-Szanto
Publikováno v:
Stem Cell Reports
Summary Two principal stem cell pools orchestrate the rapid cell turnover in the intestinal epithelium. Rapidly cycling Lgr5+ stem cells are intercalated between the Paneth cells at the crypt base (CBCs) and injury-resistant reserve stem cells reside
Autor:
Janusz Franco-Barraza, Débora Barbosa Vendramini-Costa, Igor Astsaturov, Andres J. Klein-Szanto, Tiffany Luong, Ralph Francescone, Kerry S. Campbell, Edna Cukierman, Huamin Wang, Kathy Q. Cai
Publikováno v:
Cancer Research. 81:LT019-LT019
Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, features a highly immunosuppressive environment, with expansion of cancer-associated fibroblasts (CAFs), and absence/inactivation of antitumor immune cells. Therefore, ways to man
Autor:
Koji Tanaka, Yoshiaki Kita, Jeffrey D. Winkler, Andres J. Klein-Szanto, Douglas S. Darling, Hiroshi Nakagawa, Satish Srinivasan, Manti Guha, Anil K. Rustgi, Ravi K. Amaravadi, Narayan G. Avadhani, Kelly A. Whelan, Mitsuteru Natsuizaka, Prasanna M. Chandramouleeswaran, Shoji Natsugoe
Publikováno v:
Oncogene
High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient out
Autor:
Edison Mejia, Miguel Garcia-Diaz, Jeelan Basha, Hiroshi Nakagawa, Eric F. Rappaport, Andres J. Klein-Szanto, Narayan G. Avadhani, Tapas K. Kundu, Satish Srinivasan, Ji-Kang Fang, Kip E. Guja, Manti Guha, Gordon Ruthel, Brett A. Kaufman, F. Brad Johnson, M. Rebecca Glineburg
Publikováno v:
Cell Discovery
Cell Discovery, Vol 5, Iss 1, Pp 1-1 (2019)
Cell Discovery, Vol 5, Iss 1, Pp 1-1 (2019)
Reduced mitochondrial DNA copy number, mitochondrial DNA mutations or disruption of electron transfer chain complexes induce mitochondria-to-nucleus retrograde signaling, which induces global change in nuclear gene expression ultimately contributing
Autor:
Andres J. Klein-Szanto, Javier S. Castresana, Daniel E. Bassi, Gary Thomas, Ricardo Lopez de Cicco, Javier Mercapide
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(8)
Purpose: Astrocytoma arises in the central nervous system as a tumorof great lethality, in part because of the invasive potential of the neoplastic cells that are able to release extracellular matrix-degrading enzymes. Furin convertase activates seve
Autor:
Priya Chatterji, Shun Liang, Premal Shah, Kathryn E. Hamilton, Anil K. Rustgi, Philip Hicks, Christopher J. Lengner, Amanda T. Mah, Jason R. Pitarresi, H. R. Sagara Wijeratne, Laurianne Van Landeghem, Andres J. Klein-Szanto, Brian D. Gregory, Lauren Simon, Sarah F. Andres, Blair B. Madison, Shawn W. Foley, Rei Mizuno
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c9891451436aca7a5c710d79a14e7b
https://europepmc.org/articles/PMC6075153/
https://europepmc.org/articles/PMC6075153/
Autor:
Manti Guha, Prasanna M. Chandramouleeswaran, Andres J. Klein-Szanto, James Garifallou, Clementina Mesaros, Hiroshi Nakagawa, Renata Pellegrino da Silva, Ian A. Blair, Noah Engel, Eishi Noguchi, Joseph A. Baur, Masataka Shimonosono, Hakon Hakonarson, Uma M. Sachdeva, Gordon Ruthel, Michael Gonzalez, Shinya Ohashi, Hisatsugu Maekawa, Kelly A. Whelan, Sarmistha Mukherjee
Publikováno v:
BASE-Bielefeld Academic Search Engine
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While