Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alexey A. Petrov"'
Publikováno v:
Cellular and Molecular Neurobiology. 43:729-739
Publikováno v:
Free Radical Biology and Medicine. 174:121-134
Inflammatory reactions induce changes in the neuromuscular system. The mechanisms underlying this link are unclear. Besides cytokines and reactive oxygen species (ROS), production of an antiviral oxysterol 25-hydroxycholesterol (25HC) by immune cells
Publikováno v:
Neurotherapeutics
Cholesterol and 24-hydroxycholesterol are the most abundant brain sterols and represent the substrate and product, respectively, of cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. CYP46A1 controls cholesterol elimination and turnover in the br
Autor:
Irina A. Pikuleva, Erin Prendergast, Tung Dao, Aicha Saadane, Ilya Bederman, Emmy Schwarz, Artem A. Astafev, Alexey M. Petrov, Natalia Mast, Nicole El-Darzi
Publikováno v:
Cellular and Molecular Life Sciences. 78:963-983
Apolipoprotein D (APOD) is an atypical apolipoprotein with unknown significance for retinal structure and function. Conversely, apolipoprotein E (APOE) is a typical apolipoprotein with established roles in retinal cholesterol transport. Herein, we im
Publikováno v:
FASEB J
Efavirenz (EFV) is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is the major brain cholesterol hydroxylase. Previously, we discovered that EFV activates CYP46A1 and improves behavioral performance in 5XFAD mice, an Alzheimer’s disease model
Autor:
Irina A. Pikuleva, Nicole El-Darzi, Ahab Alnemri, Tung Dao, Ying Song, Alexey M. Petrov, Natalia Mast, Joshua L. Dunaief, Aicha Saadane
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2368-2382 (2018)
Apolipoprotein E (APOE) is a component of lipid-transporting particles and a recognition ligand for receptors, which bind these particles. The APOE isoform ε2 is a risk factor for age-related macular degeneration; nevertheless, APOE absence in human
Publikováno v:
Brain Commun
Cytochrome P450 46A1 encoded by CYP46A1 catalyzes cholesterol 24-hydroxylation and is a CNS-specific enzyme that controls cholesterol removal and turnover in the brain. Accumulating data suggest that increases in cytochrome P450 46A1 activity in mous
Publikováno v:
Free radical biologymedicine. 155
Cd2+ is one of the most widespread environmental pollutants and its accumulation in central and peripheral nervous systems leads to neurotoxicity as well as aggravation of common neurodegenerative diseases. Mechanism of the Cd2+ toxicity is far from
Publikováno v:
Biochemical and biophysical research communications. 524(3)
Previously, we found that muscarine downregulates the acetylcholine release at the frog neuromuscular junction acting via M3 muscarinic receptors. Here, the molecular mechanisms underlying the inhibitory effect of muscarine on the quantal secretion o
Publikováno v:
Cellular signalling. 67
Oxidation of membrane cholesterol is a hallmark of many pathological conditions, including cardiovascular diseases. Cholesterol could be oxidized in a result of free radical and enzymatic reactions. Here, we studied the effect of cholesterol oxidatio