Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tetsuya Hosooka"'
Autor:
Daisuke Kohno, Gerard Karsenty, Wataru Ogawa, Kazuhiro Nomura, Tetsuya Hosooka, Naoki Kuramoto, Tadahiro Kitamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Phosphatidylinositol 3-kinase (PI3K) plays an important role in protein metabolism and cell growth. We here show that mice (M-PDK1KO mice) with skeletal muscle–specific deficiency of 3′-phosphoinositide–dependent kinase 1 (PDK1), a key componen
Autor:
Takaya Satoh, Nobuyuki Takenaka, Keiko Matsuda, Yukio Sumi, Tetsuya Noguchi, Junko Fujita, Tetsuya Hosooka, Atsu Aiba
Publikováno v:
Biochemical Journal. 469(3):445-454
application/pdf
Biochemical Journal. 2015, 469 (3), P.445-454
Biochemical Journal. 2015, 469 (3), P.445-454
Autor:
Anny Usheva, David A. Phillips, Hiroshi Maruyama, Ann Hammarstedt, Ulf Smith, Barbara B. Kahn, Bettina J. Kraus, Mark M. Yore, Tetsuya Hosooka, Julie Norseen, Shashi Kant, Roger J. Davis, Pratik Aryal, Urban A. Kiernan
Publikováno v:
Molecular and Cellular Biology. 32:2010-2019
Retinol-binding protein 4 (RBP4), the sole retinol transporter in blood, is secreted from adipocytes and liver. Serum RBP4 levels correlate highly with insulin resistance, other metabolic syndrome factors, and cardiovascular disease. Elevated serum R
Autor:
Yuma Nihata, Tetsuya Noguchi, Junyuan Wu, Takaya Satoh, Nobuyuki Takenaka, Tetsuya Hosooka, Wataru Ogawa, Atsu Aiba, Rumi Izawa, Kaho Kitagawa
Publikováno v:
The FEBS journalReferences. 281(5)
Insulin promotes glucose uptake in skeletal muscle by inducing the translocation of the glucose transporter GLUT4 to the plasma membrane. The serine/threonine kinase Akt2 has been implicated as a key regulator of this insulin action. However, the mec
Autor:
Tetsuya Hosooka, Masamitsu Ichihashi, Takashi Matozaki, Tetsuya Noguchi, Hiroshi Nagai, Tatsuya Horikawa, Masato Kasuga
Dok-1 (p62(Dok)) is a multiple-site docking protein that acts downstream of receptor and nonreceptor tyrosine kinases. Although it has been proposed to contribute to the control of cell growth and migration through association with the Ras GTPase-act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a0103cd15208cb75ab65b6c65af4b0
https://europepmc.org/articles/PMC87266/
https://europepmc.org/articles/PMC87266/
Autor:
Shizuo Akira, Takashi Matozaki, Toshiyuki Takada, Tetsuya Noguchi, Takuji Yamao, Kenjiro Inagaki, Masato Kasuga, Kaoru Fukunaga, Tetsuya Hosooka
The transmembrane glycoprotein SHPS-1 binds the protein tyrosine phosphatase SHP-2 and serves as its substrate. Although SHPS-1 has been implicated in growth factor- and cell adhesion-induced signaling, its biological role has remained unknown. Fibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638f0fa78419ea2c49b1525fcc782f73
https://europepmc.org/articles/PMC305898/
https://europepmc.org/articles/PMC305898/
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (12):3192-3201
Insulin resistance is characterized as a pathogenic factor in type 2 diabetes. Despite skeletal muscle being primarily responsible for systemic glucose disposal, the mechanisms underlying the induction of insulin resistance in skeletal muscle have no