Zobrazeno 1 - 10
of 565
pro vyhledávání: ''
Autor:
Hans Lassmann, Rosa Meza-Acevedo, Jae K. Ryu, Belinda S. Cabriga, Reuben Thomas, Katerina Akassoglou, Mark A. Petersen, Zhaoqi Yan, Yungui Zhou, Eric A. Bushong, Reshmi Tognatta, Anke Meyer-Franke, Mario Merlini, Mark H. Ellisman, Andrew S. Mendiola, Abinaya Muthusamy
Publikováno v:
Brain : a journal of neurology, vol 144, iss 8
Brain
Brain
Extrinsic inhibitors at sites of blood–brain barrier disruption and neurovascular damage contribute to remyelination failure in neurological diseases. However, therapies to overcome the extrinsic inhibition of remyelination are not widely available
Publikováno v:
EMBO Rep
N-glycans are molecularly diverse sugars borne by over 70% of proteins transiting the secretory pathway and have been implicated in protein folding, stability, and localization. Mutations in genes important for N-glycosylation result in congenital di
Autor:
Nicole S. Clairmont, Tania Berrocal, Tanu Priya, Z. Beau Reneer, Avery Pong, Ted M. Ross, Matthew Walker, Yixuan J. Hou, Marsha L. Mason, Nuria Codina, Alexander Chen, Hong Peng, Luis M. Blancas-Mejia, Ryan Swanson, Jerry Chen, Tien-Ying Hsiang, Kevin Shengyang Yu, Michael Gale, Deborah H. Fuller, Carl Walkey, Jorgen Nelson, Renan Vergara, Anna Josephson-Day, Pamela J. Bjorkman, Wen Su, Daniel-Adriano Silva, Thomas W. Linsky, Ralph S. Baric, Masaya Mitsumoto, Hui-Ling Yen, Uland Y. Lau, Christopher O. Barnes, Javier Castellanos, Yu-Ru Lin, Katharina Esser-Nobis
Publikováno v:
Science (New York, N.y.)
Science
Science
A decoy to neutralize SARS-CoV-2 Many efforts to develop therapies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are focused on the interaction between the spike protein, which decorates the surface of the virus, and its host r
Autor:
Cheuk Hei Ho, Jessica E. Treisman, Chiara Paolantoni, Stuart M. Brown, Praveen Bawankar, Zuojian Tang, Jean-Yves Roignant
Publikováno v:
EMBO Rep
The exon junction complex controls the translation, degradation, and localization of spliced mRNAs, and three of its core subunits also play a role in splicing. Here, we show that a fourth subunit, Barentsz, has distinct functions within and separate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf4635437ae1886d5b477f775bf14d1
https://europepmc.org/articles/PMC8728599/
https://europepmc.org/articles/PMC8728599/
Autor:
Amélie Fradet-Turcotte, Daniel Durocher, Natasha Chaudhary, Anne Margriet Heijink, Salomé Adam, Sylvie M. Noordermeer, Alana Sherker
Publikováno v:
EMBO Reports, 22(12). WILEY
EMBO Reports
EMBO Reports
The tumor suppressor BRCA1 accumulates at sites of DNA damage in a ubiquitin‐dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 recruitment to damaged chromatin. We find that RAP80 acts redundantly with the BRCA1 RING d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f77b907f13feee402844efe9db9b476
https://doi.org/10.15252/embr.202153679
https://doi.org/10.15252/embr.202153679
Autor:
Patrícia Corredeira, Sara Costa-Pereira, Bruno Silva-Santos, Julie C. Ribot, Luis Costa, Gisela Gordino, Patrícia Alves, Anita Quintal Gomes
Publikováno v:
EMBO Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© 2021 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original
Publikováno v:
BMB Reports
Nucleotide-binding oligomerization domain protein 2 (NOD2), an intracellular pattern recognition receptor, plays important roles in inflammation and cell death. Previously, we have shown that NOD2 is expressed in vascular smooth muscle cells (VSMCs)
Autor:
Miha Modic, Jamie S. Mitchell, Jacob Neeves, Jernej Ule, Linda Greensmith, Raphaëlle Luisier, Doaa M Taha, Jia Newcombe, Ione Meyer, Giulia E. Tyzack, Rickie Patani, Nicholas M. Luscombe
Publikováno v:
Brain
See Vidal and Atkin (doi:10.1093/brain/awz256) for a scientific commentary on this article. ALS remains incurable due to an incomplete understanding of its molecular pathogenesis. Tyzack, Luisier et al. report that FUS protein, previously thought to
Foxd3 controls heterochromatin‐mediated repression of repeat elements and 2‐cell state transcription
Autor:
Megumi Onishi-Seebacher, Thomas Montavon, Devon Ryan, Bettina Engist, Deepika Puri, Birgit Koschorz, Mamilla Soujanya
Publikováno v:
EMBO Reports
Repeat element transcription plays a vital role in early embryonic development. The expression of repeats such as MERVL characterises mouse embryos at the 2‐cell stage and defines a 2‐cell‐like cell (2CLC) population in a mouse embryonic stem c
Publikováno v:
EMBO Rep
Bacteria use a variety of mechanisms, such as two-component regulatory systems (TCSs), to rapidly sense and respond to distinct conditions and signals in their host organisms. For example, a type III secretion system (T3SS) is a key determinant of th