Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Komuro, A."'
Autor:
Jin Komuro, Yuta Tokuoka, Tomohisa Seki, Dai Kusumoto, Hisayuki Hashimoto, Toshiomi Katsuki, Takahiro Nakamura, Yohei Akiba, Thukaa Kuoka, Mai Kimura, Takahiro Yamada, Keiichi Fukuda, Akira Funahashi, Shinsuke Yuasa
Publikováno v:
Biochemical and Biophysical Research Communications. 632:181-188
The number of patients with heart failure and related deaths is rapidly increasing worldwide, making it a major problem. Cardiac hypertrophy is a crucial preliminary step in heart failure, but its treatment has not yet been fully successful. In this
Autor:
Shun Nakamura, Genri Numata, Toshihiro Yamaguchi, Hiroyuki Tokiwa, Yasutomi Higashikuni, Seitaro Nomura, Tetsuo Sasano, Eiki Takimoto, Issei Komuro
Publikováno v:
Biochemical and Biophysical Research Communications. 637:247-253
Dopamine D1 receptor (D1R), coded by the Drd1 gene, is induced in cardiomyocytes of failing hearts, triggering heart failure-associated ventricular arrhythmia, and therefore could be a potential therapeutic target for chronic heart failure. The regul
Autor:
Jong-Kook Lee, Sanae Hamanaka, Satoki Tomoyama, Tomoyuki Yamaguchi, Akira Yoshida, Issei Komuro, Hiromitsu Nakauchi, Yoshiki Sawa, Keiko Miwa, Keiichi Shirakawa, Yasushi Sakata, Shigeru Miyagawa
Publikováno v:
EP Europace. 20:1553-1560
Aims The aim of the present study is to develop in vitro experimental analytical method for the electrophysiological properties of allogeneic induced pluripotent stem cell-derived cardiomyocytes (CMs) in cardiac conduction defect model. Methods and r
Autor:
Takashi Matsuzaki, Hidetaka Kioka, Yasunori Shintani, Masasuke Yoshida, Hiroyuki Noji, Masafumi Kitakaze, Kazuaki Takafuji, Hisakazu Kato, Osamu Tsukamoto, Atsushi Nakano, Hiroshi Asanuma, Issei Komuro, Tetsuo Minamino, Makoto Fujikawa, Toshiharu Suzuki, Masanori Asakura, Hiromi Imamura, Yoshihiro Asano, Seiji Takashima, Satoru Yamazaki, Shuichiro Higo
Publikováno v:
Proceedings of the National Academy of Sciences. 111:273-278
The oxidative phosphorylation (OXPHOS) system generates most of the ATP in respiring cells. ATP-depleting conditions, such as hypoxia, trigger responses that promote ATP production. However, how OXPHOS is regulated during hypoxia has yet to be elucid
Publikováno v:
The Journal of Neuroscience. 30:6658-6666
Axonal degeneration contributes to permanent neurological disability in inherited and acquired diseases of myelin. Mitochondrial dysfunction has been proposed as a major contributor to this axonal degeneration. It remains to be determined, however, i
Publikováno v:
Fetal and Pediatric Pathology. 29:133-143
Amniotic epithelial cells (AEC) are thought to represent a stem-like cell population and to be an attractive cell source for regenerative medicine, because abundant cells can be obtained noninvasively at delivery. The authors investigated the neural
Autor:
Satomi Kita, Eiichi Ishikawa, Keiji Wada, Mami Noda, Masataka Ifuku, Issei Komuro, Katrin Färber, Takahiro Iwamoto, Hiroaki Ooboshi, Vanessa F. Merrino, Yukiko Yamakawa, Yuko Okuno, Bing Wang, Giselle Cheung, Taiki Miyamoto, Christiane Nolte, Helmut Kettenmann, Michael Bader
Publikováno v:
The Journal of Neuroscience. 27:13065-13073
Bradykinin (BK) is produced and acts at the site of injury and inflammation. In the CNS, migration of microglia toward the lesion site plays an important role pathologically. In the present study, we investigated the effect of BK on microglial migrat
Publikováno v:
The Journal of Neuroscience. 26:2458-2466
In the mammalian CNS, oligodendrocyte precursor cells (OPCs) express most neurotransmitter receptors, but their function remains unclear. The current studies suggest a physiological role for glutamate (AMPA and/or kainate) receptors in OPC migration.
Autor:
Toshio Nagai, Katsuhisa Matsuura, Hiroshi Akazawa, Yoshihiro Iijima, Jeffery D. Molkentin, Hiroshi Wada, Masanori Sano, Tohru Minamino, Issei Komuro, Hiroshi Kasanuki
Publikováno v:
The Journal of Cell Biology
The concept of the plasticity or transdifferentiation of adult stem cells has been challenged by the phenomenon of cell fusion. In this work, we examined whether neonatal cardiomyocytes fuse with various somatic cells including endothelial cells, car
Autor:
Yasushi Imai, Ryozo Nagai, Yunzeng Zou, Yoshio Yazaki, Masaki Shimoyama, Koichiro Harada, Koshiro Monzen, Doubun Hayashi, Issei Komuro, Ichiro Shiojima, Sumiyo Kudoh, Tsutomu Yamazaki
Publikováno v:
Biochemical and Biophysical Research Communications. 322:310-319
Cardiac hypertrophy is formed in response to hemodynamic overload. Although a variety of factors such as catecholamines, angiotensin II (AngII), and endothelin-1 (ET-1) have been reported to induce cardiac hypertrophy, little is known regarding the f