Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Thomas H"'
Autor:
Thomas H. Wesselink, Klaas P. J. M. van Gisbergen, Natasja A. M. Kragten, Astrid A. Bovens, Regina Stark, René A. W. van Lier, Felix M. Behr
Publikováno v:
European journal of immunology, 50(10), 1515-1524. Wiley-VCH Verlag
Invariant natural killer T cells (iNKT) constitute up to 50% of liver lymphocytes and contribute to immunosurveillance as well as pathogenesis of the liver. Systemic activation of iNKT cells induces acute immune-mediated liver injury. However, how ti
Autor:
Megan A. Mendenhall, Makayla K. Portley, Shihui Liu, Rasem J. Fattah, Mahtab Moayeri, Jaspal S. Khillan, Danielle O'Mard, Stephen H. Leppla, Roman Szabo, Thomas H. Bugge
Publikováno v:
Nature Microbiology. 5:1464-1471
Anthrax lethal toxin (LT), produced by Bacillus anthracis, comprises a receptor-binding moiety, protective antigen and the lethal factor (LF) protease1,2. Although LF is known to cleave mitogen-activated protein kinase kinases (MEKs/MKKs) and some va
Autor:
Robin van Eenige, Wietse In het Panhuis, Milena Schönke, Céline Jouffe, Thomas H. Devilee, Ricky Siebeler, Trea C.M. Streefland, Hetty C.M. Sips, Amanda C.M. Pronk, Ruben H.P. Vorderman, Hailiang Mei, Jan Bert van Klinken, Michel van Weeghel, Nina H. Uhlenhaut, Sander Kersten, Patrick C.N. Rensen, Sander Kooijman
Publikováno v:
Molecular Metabolism, 60
Mol. Metab. 60:101497 (2022)
Molecular metabolism, 60:101497. Elsevier GmbH
Molecular Metabolism 60 (2022)
MOLECULAR METABOLISM, 60. ELSEVIER
Mol. Metab. 60:101497 (2022)
Molecular metabolism, 60:101497. Elsevier GmbH
Molecular Metabolism 60 (2022)
MOLECULAR METABOLISM, 60. ELSEVIER
Objective: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ce49a8ed0f4fd313383e09d5996bc6
https://research.wur.nl/en/publications/angiopoietin-like-4-governs-diurnal-lipoprotein-lipase-activity-i
https://research.wur.nl/en/publications/angiopoietin-like-4-governs-diurnal-lipoprotein-lipase-activity-i
Autor:
John J. Osterholzer, Kevin K. Kim, Song Ling, Jibing Yang, Thomas H. Sisson, Seagal Teitz-Tennenbaum, Manisha Agarwal, Rachel L. Zemans
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Accumulating evidence suggests that fibrosis is a multicellular process with contributions from alveolar epithelial cells (AECs), recruited monocytes/macrophages, and fibroblasts. We have previously shown that AEC injury is sufficient to induce fibro
Autor:
Guy C. C. Allen, Leire M. Ledahawsky, Elizabeth R. Evans, Molly Scott, Kosala N. Dissanayake, Clifford C. Shone, Paul Skehel, Veronika Boczonadi, Richard R. Ribchester, Ross A. Jones, Cornelia Roesl, Thomas M. Wishart, Graeme R. Jordan, Clarke R. Slater, Richard J. Mead, David Hughes, Alanna Thomson, Thomas H. Gillingwater
Publikováno v:
Biomolecules, Vol 11, Iss 1499, p 1499 (2021)
Biomolecules
Volume 11
Issue 10
Biomolecules
Volume 11
Issue 10
Live imaging of neuromuscular junctions (NMJs) in situ has been constrained by the suitability of ligands for inert vital staining of motor nerve terminals. Here, we constructed several truncated derivatives of the tetanus toxin C-fragment (TetC) fus
Autor:
Dana N. Thornlow, Andrew N. Macintyre, Thomas H. Oguin, Amelia B. Karlsson, Erica L. Stover, Heather E. Lynch, Gregory D. Sempowski, Aaron G. Schmidt
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Influenza virus alters glycosylation patterns on its surface exposed glycoproteins to evade host adaptive immune responses. The viral hemagglutinin (HA), in particular the H3 subtype, has increased its overall surface glycosylation since its introduc
Autor:
Malachia Y. Hoover, Thomas H. Ambrosi, Norma Neff, Lauren S. Koepke, Holly Steininger, Maurizio Morri, Wan Jin Lu, Yuting Wang, Rahul Sinha, Michael T. Longaker, Matthew P. Murphy, Irving L. Weissman, Charles Chan
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Skeletal stem and progenitor cell populations are crucial for bone physiology. Characterization of these cell types remains restricted to heterogenous bulk populations with limited information on whether they are unique or overlap with previously cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44995396c88f25eb39925d11c0872f78
https://escholarship.org/uc/item/5501x19b
https://escholarship.org/uc/item/5501x19b
Autor:
Michelle S M A Damen, Maria E. Moreno-Fernandez, Stavra A. Xanthakos, Lindsey E. Romick-Rosendale, Nathan Salomonis, Amy S. Shah, Kashish Chetal, Daniel A. Giles, Sara Szabo, Michael A. Helmrath, Jarren R Oates, Calvin C. Chan, Traci E. Stankiewicz, Thomas H. Inge, Xiaoting Chen, Jessica R Doll, Rebekah Karns, Senad Divanovic, Rachel Sheridan, Hitesh Deshmukh, Matthew T. Weirauch
Publikováno v:
Cell Metab
Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD) pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic Th17 cells, however, remain unknown. Here, we uncover and characterize a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e9f8c394017d703a607992701ff8f7
https://europepmc.org/articles/PMC8237408/
https://europepmc.org/articles/PMC8237408/
Autor:
Randee Sedaka, Bryan K. Becker, Chunhua Jin, Shannon M. Bailey, Dingguo Zhang, Paramita Pati, Jennifer S. Pollock, John Miller Allan, Jennifer A Valcin, Thomas H. Neder, Telisha Millender-Swain, David M. Pollock
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
The liver plays a central role that influences cardiovascular disease outcomes through regulation of glucose and lipid metabolism. It is recognized that the local liver molecular clock regulates some liver-derived metabolites. However, it is unknown
Autor:
Niels Behrendt, Lars H. Engelholm, Katharina Wassilew, Kirstine S Nørregaard, Megan M. Sibree, Henrik J. Jürgensen, Daniel H. Madsen, Thomas H. Bugge, Dorrit Krustrup, Eric Santoni-Rugiu, Peter Garred
Publikováno v:
The Journal of Cell Biology
Tissue injury can lead to fibrotic disease and chronic inflammation, for example, in the lungs of patients with idiopathic pulmonary fibrosis. Jürgensen et al. report that fibroblasts regulate immune responses during tissue injury by clearing collec