Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Komuro, A."'
Autor:
Jin Komuro, Yuta Tokuoka, Tomohisa Seki, Dai Kusumoto, Hisayuki Hashimoto, Toshiomi Katsuki, Takahiro Nakamura, Yohei Akiba, Thukaa Kuoka, Mai Kimura, Takahiro Yamada, Keiichi Fukuda, Akira Funahashi, Shinsuke Yuasa
Publikováno v:
Biochemical and Biophysical Research Communications. 632:181-188
The number of patients with heart failure and related deaths is rapidly increasing worldwide, making it a major problem. Cardiac hypertrophy is a crucial preliminary step in heart failure, but its treatment has not yet been fully successful. In this
Autor:
Shun Nakamura, Genri Numata, Toshihiro Yamaguchi, Hiroyuki Tokiwa, Yasutomi Higashikuni, Seitaro Nomura, Tetsuo Sasano, Eiki Takimoto, Issei Komuro
Publikováno v:
Biochemical and Biophysical Research Communications. 637:247-253
Dopamine D1 receptor (D1R), coded by the Drd1 gene, is induced in cardiomyocytes of failing hearts, triggering heart failure-associated ventricular arrhythmia, and therefore could be a potential therapeutic target for chronic heart failure. The regul
Autor:
Hiroyuki Morita, Atsuhiko T. Naito, Masamichi Ito, Hironori Hara, Masanobu Uchiyama, Yutaka Hata, Seitaro Nomura, Masaki Kondo, Norifumi Takeda, Issei Komuro
Publikováno v:
Journal of Molecular and Cellular Cardiology. 128:90-95
Background Since regenerative capacity of adult mammalian myocardium is limited, activation of the endogenous proliferative capacity of existing cardiomyocytes is a potential therapeutic strategy for treating heart diseases accompanied by cardiomyocy
Autor:
Katsuhito Fujiu, Ichiro Manabe, Junichi Sugita, Masaki Suimye Morioka, Fujimi Kudo, Yukiteru Nakayama, Yusuke Endo, Atsushi Kaneda, Toshinori Nakayama, Tsukasa Oshima, Issei Komuro, Yumiko Oishi, Ryozo Nagai, Ryuzaburo Yuki, Takayuki Isagawa, Takumi Matsubara, Jun Matsuda
Publikováno v:
Proc Natl Acad Sci U S A
Proper resolution of inflammation is vital for repair and restoration of homeostasis after tissue damage, and its dysregulation underlies various noncommunicable diseases, such as cardiovascular and metabolic diseases. Macrophages play diverse roles
Autor:
Masakiyo Sasahara, Noboru Hatakeyama, Naoyuki Matsuda, Hiroshi Sagara, Mitsuko Dohmoto, Bon Nyeo Koo, Shumpei Niida, Isao Usui, Erin O'Donnell, Seiji Yamamoto, Yasuhide Watanabe, Kiyoshi Takatsu, Masashi Ikutani, Satomi Kita, Ken-ichi Takano, Erika Azuma, Kazuyuki Tobe, Tsuyoshi Osawa, Michiya Sugimori, Issei Komuro, Yoshinori Nagai, Takahiro Iwamoto, Masabumi Shibuya, Masashi Muramatsu, Hiroyuki Takahashi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at t
Autor:
Ichiro Manabe, Koji Maemura, Norihiko Takeda, Issei Komuro, Yasushi Hirota, Masaki Suimye Morioka, Tatsuyuki Sato, Masaki Wake, Takayuki Isagawa, Kazuaki Tanabe, Yu Nakagama, Masataka Asagiri
Publikováno v:
International heart journal. 60(4)
Myocardial infarction (MI) occurs when the heart muscle is severely damaged due to a decrease in blood flow from the coronary arteries. During recovery from an MI, cardiac fibroblasts become activated and produce extracellular matrices, contributing
Autor:
Katsura Soma, Koji Maemura, Hiroaki Semba, Masaki Suimye Morioka, Masataka Asagiri, Takayuki Isagawa, Kinya Otsu, Takeshi Yamashita, Satoshi Nishimura, Hajime Abe, Tomo Yonezawa, Yasushi Hirota, Ryozo Nagai, Tatsuyuki Sato, Norihiko Takeda, Manami Katoh, Katsuhiro Koyama, Ryo Inuzuka, Ichiro Manabe, Yu Nakagama, Michael L. Neugent, Jung Whan Kim, Issei Komuro, Masaki Wake, Christian Stockmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Abe, H, Takeda, N, Isagawa, T, Semba, H, Nishimura, S, Morioka, M S, Nakagama, Y, Sato, T, Soma, K, Koyama, K, Wake, M, Katoh, M, Asagiri, M, Neugent, M L, Kim, J W, Stockmann, C, Yonezawa, T, Inuzuka, R, Hirota, Y, Maemura, K, Yamashita, T, Otsu, K, Manabe, I, Nagai, R & Komuro, I 2019, ' Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M ', Nature Communications, vol. 10, no. 1, 2824 . https://doi.org/10.1038/s41467-019-10859-w
Nature Communications
Abe, H, Takeda, N, Isagawa, T, Semba, H, Nishimura, S, Morioka, M S, Nakagama, Y, Sato, T, Soma, K, Koyama, K, Wake, M, Katoh, M, Asagiri, M, Neugent, M L, Kim, J W, Stockmann, C, Yonezawa, T, Inuzuka, R, Hirota, Y, Maemura, K, Yamashita, T, Otsu, K, Manabe, I, Nagai, R & Komuro, I 2019, ' Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M ', Nature Communications, vol. 10, no. 1, 2824 . https://doi.org/10.1038/s41467-019-10859-w
Nature Communications
The fibrogenic response in tissue-resident fibroblasts is determined by the balance between activation and repression signals from the tissue microenvironment. While the molecular pathways by which transforming growth factor-1 (TGF-β1) activates pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4108e8d5ad1f2fd9f417612d5cd40d4
https://doi.org/10.5167/uzh-171771
https://doi.org/10.5167/uzh-171771
Autor:
Satoshi Ishii, Mutsuo Harada, Hiroyuki Morita, Tsubasa Kanaya, Haruhiro Toko, Hironori Hara, Takaaki Suzuki, Harold L. Moses, Issei Komuro, Eiki Takimoto, Sonoko Maemura, Hiroki Yagi, Hideaki Ijichi, Hiroshi Akazawa, Norifumi Takeda, Takayuki Fujiwara
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0239908 (2020)
PLoS ONE
PLoS ONE
Increased transforming growth factor-β (TGF-β) signaling contributes to the pathophysiology of aortic aneurysm in Marfan syndrome (MFS). Recent reports indicate that a small but significant number of inflammatory cells are infiltrated into the aort
Autor:
Issei Komuro, Hiroshi Akazawa, Ikuko Nakanomyo, Shigeomi Shimizu, Yoko Kudo-Sakamoto, Satoko Arakawa
Publikováno v:
Biochemical and Biophysical Research Communications. 467:1006-1011
In various pathological events, particularly in oxygen radical-mediated cell injury, both apoptosis and necrosis play essential roles. Apoptosis and some types of necrosis are induced via increases in mitochondrial membrane permeability, called mitoc
Autor:
Taro Kariya, Mutsuo Harada, Tomokazu Sumida, Kanna Fujita, Toshiyuki Ko, Atsuhiko T. Naito, Takashige Tobita, Yoshio Kobayashi, Masamichi Ito, Issei Komuro, Hiroyuki Morita, Eiki Takimoto, Toshihiro Yamaguchi, Masato Ishizuka, Haruhiro Toko, Masahiro Satoh, Seitaro Nomura, Hiroyuki Aburatani, Takanori Fujita, Norifumi Takeda, Hiroshi Akazawa
Publikováno v:
Journal of molecular and cellular cardiology. 128
Background The heart responds to hemodynamic overload through cardiac hypertrophy and activation of the fetal gene program. However, these changes have not been thoroughly examined in individual cardiomyocytes, and the relation between cardiomyocyte