Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ye Zheng"'
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo
Autor:
Jovylyn Gatchalian, Chin-San Loo, Bhargav Venkatraghavan, Yuqiong Liang, Josephine Ho, Ye Zheng, Diana C. Hargreaves, Mingjun Xie, Mathias Leblanc
Publikováno v:
Immunity
Summary Regulatory T (Treg) cells play a pivotal role in suppressing auto-reactive T cells and maintaining immune homeostasis. Treg cell development and function are dependent on the transcription factor Foxp3. Here, we performed a genome-wide CRISPR
Autor:
Kelly A. Remedios, Mark H. Ginsberg, Jane E. Klann, Justine Lopez, Brian G. Petrich, Lauren A. Mack, John T. Chang, Stephanie H. Kim, Ye Zheng, Patrick J. Metz
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 198, iss 12
Talin, a cytoskeletal protein essential in mediating integrin activation, has been previously shown to be involved in the regulation of T cell proliferation and function. In this study, we describe a role for talin in maintaining the homeostasis and
Autor:
Ye Zheng, Takatoshi Chinen, Arun K. Kannan, Jason D. Fontenot, Yongqiang Feng, Andrew G. Levine, Xiying Fan, Ulf Klein, Georg Gasteiger, Alexander Y. Rudensky
Publikováno v:
Nature Immunology. 17:1322-1333
Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by Treg
Autor:
Soyoung Ha, Dan R. Littman, Brandon N. Nelson, Jingping Lu, Saiyu Hang, Michael A. Fischbach, Jamma Trinath, Michael R. Krout, Donggi Paik, Ye Zheng, Samantha P. Kelly, Lin Wu, Fraydoon Rastinejad, A. Sloan Devlin, Jun R. Huh
Publikováno v:
The Journal of Immunology. 204:230.6-230.6
Bile acids are abundantly present in the mammalian gut, where they undergo bacteria-mediated transformation, generating a large pool of bioactive molecules. While they have been shown to affect host metabolism, cancer progression and innate immunity,
Autor:
Jailal N. G. Ablack, Mark H. Ginsberg, Jack D. Bui, Kelly A. Remedios, John T. Chang, Patrick J. Metz, Li-Fan Lu, Joseph M. Cantor, Jane E. Klann, Zhaoren He, Jocelyn G. Olvera, Stephanie H. Kim, Justine Lopez, Brian G. Petrich, Tiffani Tysl, Gene W. Yeo, Ye Zheng, Brigid S. Boland
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(12)
Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-extracellula
Autor:
Jovan Shepherd, Yi Liu, Ye Zheng, Christian J. Maine, Guo Fu, Mohsen Sabouri-Ghomi, Changchun Xiao, Nengming Xiao, Seung Goo Kang, Cheng-Jang Wu, Shunbin Xu, Alicia Gonzalez-Martin, Li-Fan Lu, Zhe Huang, Wen Hsien Liu, Alexander Hoffmann, Hyun Yong Jin
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 213, iss 9
instname
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 213, iss 9
Xiao and collaborators show that miR-155 regulates T follicular helper cell development and function by suppressing the E3 ubiquitin ligase Peli1.
MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the con
MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa5ed3a272de3dc5bb9fdbe6d6cbcd4
http://hdl.handle.net/10486/685850
http://hdl.handle.net/10486/685850
Publikováno v:
Nature Immunology. 7:401-410
The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3-positive (Foxp3(+)) CD4(+) regulatory T cells (T(reg) cells) and nonregulatory T cells with autoimmune potential is unclear. Here we found
Publikováno v:
The Journal of Experimental Medicine
Signaling pathways involved in regulating T cell proliferation and survival are not well understood. Here we have investigated a possible role of the nuclear factor (NF)-kappaB pathway in regulating mature T cell function by using CD4+ T cells from p
Publikováno v:
Immunity. 16:257-270
Despite the established role of dendritic cells (DCs) in regulating T lymphocyte activation, intracellular mechanisms responsible for controlling DC function are largely undefined. Here, we have studied DCs from mice deficient in the p50, RelA, and c