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Autor:
Shaoyan, Zheng, Botao, Pan
Publikováno v:
Aging. 14:8783-8804
As a multicomponent, multitarget empirical therapy, traditional Chinese medicine (TCM) has been used clinically in Asia for thousands of years. Due to this unique feature, TCM therapy is considered a promising therapeutic strategy for the treatment o
Autor:
Yujing Zhang, Yuchen Qi, Shuai Huang, Xiaodong Jiang, Weiwei Xiao, Le Wang, Ziwei Liu, Sulai Liu
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-11
The liver is a highly metabolic organ and plays a crucial role in the transportation, storage, and/or detoxication of xenobiotics. Liver damage induced by xenobiotics (e.g., heavy metal, endocrine disrupting chemicals, Chinese herbal medicine, or nan
Publikováno v:
Biochemical Journal. 479:2297-2309
If left unrepaired, the major oxidative DNA lesion 7,8-dihydro-8-oxoguanine (oxoG) promotes G-to-T transversions by favorably adopting a syn conformation and base pairing with dATP during replication. The human oxoG DNA glycosylase hOGG1 senses and r
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-14
The prodrug–enzyme regimen ZD2767P+CPG2 is limited by low efficacy. Here, ultrasound was used to modulate ZD2767P+CPG2 (i.e., ZD2767P+CPG2+US) against cisplatin-resistant human lung cancer cells. A549 and A549/DDP (resistant subline) cells received
Autor:
Shokoufeh Khanzadeh, Hossein Tahernia, Jairo Hernandez, Camila Sarcone, Brandon Lucke-Wold, Amirhosseinn Salimi, Fatemeh Tabatabaei
Publikováno v:
Mediators of Inflammation. 2022:1-8
Introduction. The goal of this systematic review and meta-analysis was to consolidate the available data on the role of the neutrophil to lymphocyte ratio (NLR) in predicting adnexal torsion (AT), to help guide clinical decision-making and outcomes.
Autor:
Marco Basset, Paolo Milani, Andrea Foli, Mario Nuvolone, Pietro Benvenuti, Martina Nanci, Francesca Fabris, Claudia Bellofiore, Giampaolo Merlini, Giovanni Palladini
Publikováno v:
Blood. 140:1964-1971
Patients with immunoglobulin light chain (AL) amyloidosis and stage IIIb cardiac involvement have a dismal outcome despite the introduction of novel treatments. However, a rapid hematologic response translates in better survival. We evaluated the imp
Autor:
Barbara Simon, Andrea Ceglédi, János Dolgos, Péter Farkas, Manila Gaddh, László Hankó, Robert Horváth, Ambrus Kaposi, Lászlóné Magyar, Tamás Masszi, Attila Szederjesi, Nikolett Wohner, Imre Bodó
Publikováno v:
Blood. 140:1983-1992
Acquired hemophilia A (AHA) is a rare severe autoimmune bleeding disorder with significant morbidity and mortality. Although critical for disease control, there is no consensus for the best immunosuppressive regimen. Most authors use steroids first l
Publikováno v:
Oxidative Medicine and Cellular Longevity, 2022:1070968. Hindawi Limited
Ovarian aging is associated with a decrease in fecundity. Increased oxidative stress of granulosa cells (GCs) is an important contributor. We thus asked whether there is an oxidative stress-related gene signature in GCs associated with ovarian aging.
Autor:
Matthew Ho, Saurabh Zanwar, Francis K. Buadi, Sikander Ailawadhi, Jeremy Larsen, Leif Bergsagel, Moritz Binder, Asher Chanan-Khan, David Dingli, Angela Dispenzieri, Rafael Fonseca, Morie A. Gertz, Wilson Gonsalves, Ronald S. Go, Suzanne Hayman, Prashant Kapoor, Taxiarchis Kourelis, Martha Q. Lacy, Nelson Leung, Yi Lin, Eli Muchtar, Vivek Roy, Taimur Sher, Rahma Warsame, Amie Fonder, Miriam Hobbs, Yi L. Hwa, Robert A. Kyle, S. Vincent Rajkumar, Shaji Kumar
Publikováno v:
Blood. 140:1997-2000
Two Letters to Blood address the risks of COVID-19 in populations with precursors of hematological disease. In the first article, Miller and colleagues report on whether clonal hematopoiesis of intermediate potential (CHIP) is associated with adverse
Autor:
Peter G. Miller, Geoffrey G. Fell, Brody H. Foy, Allison K. Scherer, Christopher J. Gibson, Adam S. Sperling, Bala B. Burugula, Tetsushi Nakao, Md M. Uddin, Hailey Warren, Lynn Bry, Olga Pozdnyakova, Matthew J. Frigault, Alex G. Bick, Donna Neuberg, John M. Higgins, Michael K. Mansour, Pradeep Natarajan, Annette S. Kim, Jacob O. Kitzman, Benjamin L. Ebert
Publikováno v:
Blood. 140:1993-1997
Two Letters to Blood address the risks of COVID-19 in populations with precursors of hematological disease. In the first article, Miller and colleagues report on whether clonal hematopoiesis of intermediate potential (CHIP) is associated with adverse