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Publikováno v:
Biochemical and Biophysical Research Communications. 638:103-111
Skin is the biggest organ of the human body, which easily gets irritated by exposure to the sun. Skin photoaging and acute photodamage are caused by intense UV-B radiation. Therefore, it is imperative to find new compounds to prevent skin damage and
Autor:
Chen, Panpan, Tian, Jingyu, Zhou, Yanying, Chen, Yixin, Zhang, Huizhen, Jiao, Tingying, Huang, Min, Zhang, Hui, Huang, Peng, Yu, Ai-Ming, Gonzalez, Frank J, Bi, Huichang
Publikováno v:
International journal of biological sciences, vol 19, iss 7
Cellular senescence is a state of proliferative arrest, and the development of carcinoma can be suppressed by conferring tumor cell senescence. Recently, we found that carnitine palmitoyltransferase 1C (CPT1C) controls tumor cell proliferation and se
Autor:
Myriam Lemmens, Juliane Perner, Leon Potgeter, Michael Zogg, Sineha Thiruchelvam, Matthias Müller, Thierry Doll, Annick Werner, Yoann Gilbart, Philippe Couttet, Hans-Jörg Martus, Silvana Libertini
Publikováno v:
Cytotherapy. 25:59-67
Engineered tissues and cell therapies based on human induced pluripotent stem cells (iPSCs) represent a promising approach for novel medicines. However, iPSC-derived cells and tissues may contain residual undifferentiated iPSCs that could lead to ter
Autor:
Zhang, Juan, Luan, Zhi-Lin, Huo, Xiao-Kui, Zhang, Min, Morisseau, Christophe, Sun, Cheng-Peng, Hammock, Bruce D, Ma, Xiao-Chi
Publikováno v:
International journal of biological sciences, vol 19, iss 1
Acute kidney injury (AKI) is a pathological condition characterized by a rapid decrease in glomerular filtration rate and nitrogenous waste accumulation during hemodynamic regulation. Alisol B, from Alisma orientale, displays anti-tumor, anti-complem
Autor:
Inez Trouwborst, Anouk Gijbels, Kelly M. Jardon, Els Siebelink, Gabby B. Hul, Lisa Wanders, Balázs Erdos, Szabolcs Péter, Cécile M. Singh-Povel, Johan de Vogel-van den Bosch, Michiel E. Adriaens, Ilja C.W. Arts, Dick H.J. Thijssen, Edith J.M. Feskens, Gijs H. Goossens, Lydia A. Afman, Ellen E. Blaak
Publikováno v:
Cell Metabolism, 35, 1, pp. 71-83
Cell Metabolism 35 (2023) 1
Cell Metabolism, 35(1), 71-83.e5
Cell Metabolism, 35(1), 71-83.e5. Cell Press
Cell Metabolism, 35, 71-83
Cell Metabolism 35 (2023) 1
Cell Metabolism, 35(1), 71-83.e5
Cell Metabolism, 35(1), 71-83.e5. Cell Press
Cell Metabolism, 35, 71-83
Summary Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant
Autor:
Martha L, Echevarría-Andino, Nicole E, Franks, Hannah E, Schrader, Mingi, Hong, Robert S, Krauss, Benjamin L, Allen
Publikováno v:
Developmental Biology. 493:1-11
Hedgehog (HH) signaling is a major driver of tissue patterning during embryonic development through the regulation of a multitude of cell behaviors including cell fate specification, proliferation, migration, and survival. HH ligands signal through t
Autor:
John R. Speakman, Jasper M. A. de Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S. W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma, Daniel Hoffman, Sumei Hu, Annemiek M. Joosen, Jennifer L. Kaplan, Peter Katzmarzyk, William E. Kraus, Robert F. Kushner, William R. Leonard, Marie Löf, Corby K. Martin, Eric Matsiko, Anine C. Medin, Erwin P. Meijer, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Susan B. Racette, David A. Raichlen, Eric Ravussin, Leanne M. Redman, Susan B. Roberts, Michael C. Rudolph, Luis B. Sardinha, Albertine J. Schuit, Analiza M. Silva, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Brian M. Wood, Jack A. Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Anura Kurpad, Amy H. Luke, Herman Pontzer, Matthew S. Rodeheffer, Jennifer Rood, Dale A. Schoeller, William W. Wong
Publikováno v:
Nature Metabolism, 5(4), 579-588. Springer Berlin
Obesity is caused by a prolonged positive energy balance1,2. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated3,4. Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composi
Publikováno v:
Seminars in Cell & Developmental Biology. 134:4-13
Extremophiles have always garnered great interest because of their exotic lifestyles and ability to thrive at the physical limits of life. In hot springs environments, the Cyanidiophyceae red algae are the only photosynthetic eukaryotes able to live
Autor:
Andrew K, Chojnacki, Saranya, Navaneetha Krishnan, Humberto, Jijon, Timothy E, Shutt, Pina, Colarusso, Derek M, McKay
Publikováno v:
Mitochondrion. 68:44-59
Mitochondrial dysfunction as defined by transcriptomic and proteomic analysis of biopsies or ultra-structure in transmission electron microscopy occurs in inflammatory bowel disease (IBD); however, mitochondrial dynamics in IBD have received minimal
Publikováno v:
Seminars in Cell & Developmental Biology. 133:123-134
Stem cells can generate a diversity of cell types during development, regeneration and adult tissue homeostasis. Differentiation changes not only the cell fate in terms of gene expression but also the physical properties and functions of cells, e.g.