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Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by the KCNJ16 gene) hav
Autor:
Sara S. Procknow, Beth A. Kozel
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Elastin provides recoil to tissues that stretch such as the lung, blood vessels, and skin. It is deposited in a brief window starting in the prenatal period and extending to adolescence in vertebrates, and then slowly turns over. Elastin insufficienc
Publikováno v:
Antioxidantsredox signaling. 37(7-9)
SIGNIFICANCE Reactive oxygen species (ROS) contribute to multiple aspects of peripheral nervous system (PNS) biology ranging from physiological processes (e.g. axonal outgrowth and regeneration), to pathophysiology (e.g. nerve degeneration). Although
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(3)
The translational value of high-throughput toxicity testing will depend on pharmacokinetic validation. Yet, popular in vitro airway epithelia models were optimized for structure and mucociliary function without considering the bioactivation or detoxi
Autor:
Elissa M. Hult, Stephen J. Gurczynski, David N. O’Dwyer, Rachel L. Zemans, Andrew Rasky, Yizhuo Wang, Susan Murray, Howard C. Crawford, Bethany B. Moore
Publikováno v:
American journal of respiratory cell and molecular biology. 67(6)
Idiopathic pulmonary fibrosis (IPF) is a poorly understood, progressive lethal lung disease with no known cure. In addition to alveolar epithelial cell (AEC) injury and excessive deposition of extracellular matrix proteins, chronic inflammation is a
Publikováno v:
Cell cycle (Georgetown, Tex.). 21(24)
Accumulating evidence has unfolded the significance of extracellular vesicles (EVs) in diseases and cancers. Here, we attempted to discuss the role of cancer-associated fibroblasts (CAFs)-derived EVs containing miR-199a-5p in gastric tumorigenesis. U
Publikováno v:
Cell cycle (Georgetown, Tex.). 21(24)
Hepatocellular carcinoma (HCC) is one of the most common cancers and has continued to increase in incidence worldwide. Moreover, the involvement of microRNAs (miRs) has been reported in the development and progression of HCC. Here, we investigated th
Autor:
Peng-Hui Zeng, Wen-Jun Yin
Publikováno v:
Cell cycle (Georgetown, Tex.). 22(1)
The cGAS/STING signaling pathway is an important part of the cytoplasmic DNA sensor, which can trigger a type I interferon response to microbial infection when pathogenic DNA is detected. However, continuous inhibition of cGAS/STING signaling by vira
Autor:
Eric Tompkins, Bogdana Mimic, Karina Cuevas-Mora, Hannah Schorsch, Sushrut D. Shah, Deepak A. Deshpande, Jeffrey L. Benovic, Raymond B. Penn, Tonio Pera
Publikováno v:
American journal of respiratory cell and molecular biology. 67(5)
G protein-coupled receptors (GPCRs) not only are turned on or off to control canonical G protein signaling but also may be fine-tuned to promote qualitative/biased signaling. Qualitative signaling by M3 muscarinic acetylcholine receptors (mAChRs) has
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(2)
Though survival rates for preterm infants are improving, the incidence of chronic lung disease of infancy, or bronchopulmonary dysplasia (BPD), remains high. Histologically, BPD is characterized by larger and fewer alveoli. Hypoxia-inducible factors