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Autor:
Yuxiao Yao, Weiping Han
Publikováno v:
Molecules and Cells. 45:781-788
Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysre
Publikováno v:
Aging. 14:8585-8594
This study aims to determine the differences in myocardial enzymes in COVID-19 patients with and without hypertension. A total of 130 patients with COVID-19 in Yunmeng County People's Hospital were analyzed. The clinical manifestations and laboratory
Autor:
Masahiro Chiba, Joji Shimono, Takashi Ishio, Norio Takei, Kohei Kasahara, Reiki Ogasawara, Takahide Ara, Hideki Goto, Koh Izumiyama, Satoko Otsuguro, Liyanage P. Perera, Hiroo Hasegawa, Michiyuki Maeda, Satoshi Hashino, Katsumi Maenaka, Takanori Teshima, Thomas A. Waldmann, Yibin Yang, Masao Nakagawa
Publikováno v:
Blood. 140(18):1951-1963
Adult T-cell leukemia/lymphoma (ATLL) is one of the aggressive peripheral T-cell neoplasms with a poor prognosis. Accumulating evidence demonstrates that escape from adaptive immunity is a hallmark of ATLL pathogenesis. However, the mechanisms by whi
Autor:
Haichao Yu, Zhen Zhang, Fahong Wei, Guowei Hou, Yonggang You, Xiangyu Wang, Shiqi Cao, Xiaoqing Yang, Weibo Liu, Shaofu Zhang, Fanqi Hu, Xuesong Zhang
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-21
Low back pain (LBP) seriously affects human quality of life. Intervertebral disc degeneration (IVDD) is the main pathological factor that leads to LBP, but the pathological mechanism underlying IVDD has not been fully elucidated. Neuropathic pain cau
Autor:
Douglas R. Kellogg, Petra Anne Levin
Publikováno v:
Trends in Cell Biology. 32:908-919
Pioneering work carried out over 60 years ago discovered that bacterial cell size is proportional to the growth rate set by nutrient availability. This relationship is traditionally referred to as the 'growth law'. Subsequent studies revealed the gro
Autor:
Yeh Chwan Leong, Valentina Di Foggia, Hema Pramod, Maria Bitner-Glindzicz, Aara Patel, Jane C. Sowden
Publikováno v:
Stem Cell Reports. 17:2421-2437
Usher syndrome-associated retinitis pigmentosa (RP) causes progressive retinal degeneration, which has no cure. The pathomechanism of Usher type 1B (USH1B)-RP caused by MYO7A mutation remains elusive because of the lack of faithful animal models and
Autor:
Jan J. Brosens, Phillip R. Bennett, Vikki M. Abrahams, Rosanna Ramhorst, Arri Coomarasamy, Siobhan Quenby, Emma S. Lucas, Rajiv C. McCoy
Publikováno v:
Seminars in Cell & Developmental Biology. 131:14-24
Compared to most mammals, human pregnancy is unusual in that it involves chromosomally diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate integration of fetal and maternal cells at the uteroplacental interface. N
Autor:
Martin, Picard, Orian S, Shirihai
Publikováno v:
Cell Metabolism. 34:1620-1653
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are
Autor:
Katherine N. MacDonald, Michael G. Hall, Sabine Ivison, Sanjiv Gandhi, Ramon I. Klein Geltink, James M. Piret, Megan K. Levings
Publikováno v:
Cytotherapy. 24:1121-1135
Given the promising results from phase 1/2 clinical trials of therapy involving regulatory T cells (Tregs), it is critical to develop Treg manufacturing methods that use well-defined reagents.Seeking to maximize expansion of human thymic Tregs activa
Publikováno v:
Cell Metabolism. 34:1654-1674
The evolution of glucagon has seen the transition from an impurity in the preparation of insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 diabetes, glucagon receptor antagonists have been explored to redu