Zobrazeno 1 - 10
of 59 812
pro vyhledávání: ''
Autor:
Lauren Schaff, Christian Grommes
Publikováno v:
Blood. 140:971-979
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or vitreoretinal space, without evidence of systemic involvement. The diagnosis of PCNSL requires a high
Autor:
Prakash Priyadarshi Praharaj, Debasna P. Panigrahi, Bishnu Prasad Behera, Kewal Kumar Mahapatra, Shankargouda Patil, Amruta Singh, Rohan Dhiman, Srimanta Patra, Soumya Ranjan Mishra, Chandra Sekhar Bhol, Sujit K. Bhutia, Samir Kumar Patra
Publikováno v:
Seminars in Cancer Biology. 83:399-412
Tumour-promoting inflammation is a critical hallmark in cancer development, and inflammasomes are well-known regulators of inflammatory processes within the tumour microenvironment. Different inflammasome components along with the adaptor, apoptosis-
Publikováno v:
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Highlights • Supported liquid extraction is easy to use as visual phase separation isn't needed. • Automated sample preparation allows fast sample process and subsequent analysis. • Automated liquid handling coupled with LC-MS/MS as high-throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696bdd3cfcd1352b7ded7761ac15ec49
https://ora.ox.ac.uk/objects/uuid:07d01ff8-82f0-4159-ab3d-3977ff5edde6
https://ora.ox.ac.uk/objects/uuid:07d01ff8-82f0-4159-ab3d-3977ff5edde6
Thrombus formation is dependent on the interaction of platelets, leukocytes and endothelial cells as well as proteins of the coagulation cascade. This interaction is tightly controlled by phospho-regulated pathways involving protein kinase CK2. A gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92a1e8f015cf6edcffd7aa22cd6d13c
Autor:
Augustine M.K. Choi, Mi-Ae Park, Mijin Yun, Chun K. Kim, Kiichi Nakahira, Jong Seok Moon, Maria Haslip, Ilias I. Siempos, Judie A. Howrylak, Patty J. Lee, Seonmin Lee, Stefan W. Ryter
Publikováno v:
Journal of Clinical Investigation. 133
Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory responses remain unclear. The NLRP3 inflammasome serves as a platform for caspase-1–depen
Autor:
Nancy L. Bartlett, Felicia Gomez, Matthew Mosior, Malachi Griffith, Anne Fischer, Michelle Becker-Hapak, Mark P. Foster, Melissa M. Berrien-Elliott, Alina D. Schmidt, Marcus Watkins, Amanda F. Cashen, Kilannin Krysiak, Kami J. Maddocks, Nina D. Wagner-Johnston, Jingqin Luo, Obi L. Griffith, Zachary L. Skidmore, Todd A. Fehniger, Sweta Desai, Jeffrey P. Ward
Publikováno v:
Blood
New therapies are needed for patients with relapsed/refractory (rel/ref) diffuse large B-cell lymphoma (DLBCL) who do not benefit from or are ineligible for stem cell transplant and chimeric antigen receptor therapy. The CD30-targeted, antibody-drug
Publikováno v:
Blood. 139:1973-1986
Disseminated intravascular coagulation (DIC) is a syndrome triggered by infectious and noninfectious pathologies characterized by excessive generation of thrombin within the vasculature and widespread proteolytic conversion of fibrinogen. Despite div
Autor:
Thomas Renné, Abhishek Upadhyay, Hanna Englert, Mareike G. Posner, Ian M. Eggleston, Stuart Wallis, Stefan Bagby, Giordano Pula, Nina Wolska
Publikováno v:
Wallis, S, Wolska, N, Englert, H, Posner, M, Upadhyay, A, Renne, T, Eggleston, I, Bagby, S & Pula, G 2022, ' A peptide from the staphylococcal protein Efb binds P-selectin and inhibits the interaction of platelets with leukocytes ', Journal of Thrombosis and Haemostasis, vol. 20, no. 3, pp. 729-741 . https://doi.org/10.1111/jth.15613, https://doi.org/10.1111/jth.15613
AimsP-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of S. aureus extracellular fibrinogen-binding protein (Efb) binds to P-selectin and interferes wit
Autor:
Jian-Feng Liu, You Jin, Jian-Guo Chen, Lan Ni, Zhuang-Li Hu, Cong Ma, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Hui-Ling Zheng, Fang Wang, Wen-Long Xie, Hou-Hong Li
Publikováno v:
Biological Psychiatry. 91:593-603
Background Depression is a common psychiatric disorder associated with the defects in GABAergic neurotransmission. α-Dystroglycan (α-DG), a cell adhesion molecule known to be essential for skeletal muscle integrity, is also present at inhibitory sy
Autor:
Shantibhusan Senapati, Amlan Priyadarshee Mohapatra, Voddu Suresh, Biswajit Das, Deepti Parida, Aliva Prity Minz, Debasish Mohapatra, Rajeeb K. Swain, Usharani Nayak
Publikováno v:
Laboratory Investigation. 102:298-311
Pancreatic cancer (PC) is highly resistant to chemo and radiotherapy. Radiation-induced fibrosis (RIF) is a major cause of clinical concern for various malignancies, including PC. In this study, we aimed to evaluate the radiosensitizing and anti-RIF